Role of Transcription Factor HAT1 in Modulating<i>Arabidopsis thaliana</i>Response to<i>Cucumber mosaic virus</i>

Zou, Lijuan; Deng, Xing-Guang; Han, Xueying; Tan, Wenrong; Zhu, Li-Jun; Xi, Dehui; Zhang, Dawei; Lin, Honghui

doi:10.1093/pcp/pcw109

Cited by 28 publications

(21 citation statements)

References 55 publications

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“…HAT1 interacts with BES1, a central regulator in BR signaling pathway, and functions as a BES1 co-repressor to inhibit BR-repressed genes and thus optimizes BR-regulated plant growth [ 30 ]. In addition, HAT1 acts as a repressor in plant defense response to CMV infection [ 31 ]. Thus, HAT1 may function as a transcriptional regulator to modulate plant growth and stress response.…”

Section: Discussionmentioning

confidence: 99%

“…It was recently reported that HAT1 is a substrate of BIN2 (BRASSINOSTEROID-INSENSITIVE 2) kinase and appears to function redundantly with other family members such as HAT3 to positively mediate BR responses [ 30 ]. HAT1 was also reported to participate in anti-CMV defense response in Arabidopsis and negatively regulates this process [ 31 ]. Collectively, these studies indicate that HAT1 is involved in the complex signaling and transcriptional networks coordinating plant growth and stress response.…”

Section: Introductionmentioning

confidence: 99%

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Transcription factor HAT1 is a substrate of SnRK2.3 kinase and negatively regulates ABA synthesis and signaling in Arabidopsis responding to drought

et al. 2018

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Drought is a major threat to plant growth and crop productivity. The phytohormone abscisic acid (ABA) plays a critical role in plant response to drought stress. Although ABA signaling-mediated drought tolerance has been widely investigated in Arabidopsis thaliana, the feedback mechanism and components negatively regulating this pathway are less well understood. Here we identified a member of Arabidopsis HD-ZIP transcription factors HAT1 which can interacts with and be phosphorylated by SnRK2s. hat1hat3, loss-of-function mutant of HAT1 and its homolog HAT3, was hypersensitive to ABA in primary root inhibition, ABA-responsive genes expression, and displayed enhanced drought tolerance, whereas HAT1 overexpressing lines were hyposensitive to ABA and less tolerant to drought stress, suggesting that HAT1 functions as a negative regulator in ABA signaling-mediated drought response. Furthermore, expression levels of ABA biosynthesis genes ABA3 and NCED3 were repressed by HAT1 directly binding to their promoters, resulting in the ABA level was increased in hat1hat3 and reduced in HAT1OX lines. Further evidence showed that both protein stability and binding activity of HAT1 was repressed by SnRK2.3 phosphorylation. Overexpressing SnRK2.3 in HAT1OX transgenic plant made a reduced HAT1 protein level and suppressed the HAT1OX phenotypes in ABA and drought response. Our results thus establish a new negative regulation mechanism of HAT1 which helps plants fine-tune their drought responses.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Transcription factor HAT1 is a substrate of SnRK2.3 kinase and negatively regulates ABA synthesis and signaling in Arabidopsis responding to drought

et al. 2018

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“…(1) The negative regulators of plant defenses, such as rgs-CaM that inhibited RNA silencing through repressing the transcription level of RDR6 and degrading the SGS3 protein via autophagy , and homeodomain leucine zipper protein 1 (HAT1) and its related genes HAT2 and HAT3, whose mutation conferred loss-of-susceptibility to CMV infection by accumulating high levels of SA and jasmonic acid (JA) (Zou et al, 2016).…”

Section: The Promising Host Susceptibility Genes For Antiviral Enginementioning

confidence: 99%

Control of Plant Viruses by CRISPR/Cas System-Mediated Adaptive Immunity

Cao

Zhou

et al. 2020

Front. Microbiol.

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Plant diseases caused by invading plant viruses pose serious threats to agricultural production in the world, and the antiviral engineering initiated by molecular biotechnology has been an effective strategy to prevent and control plant viruses. Recent advances in clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated (Cas) system-mediated DNA or RNA editing/interference in plants make them very attractive tools applicable to the plant protection field. Here, we review the development of CRISPR/Cas systems and summarize their applications in controlling different plant viruses by targeting viral sequences or host susceptibility genes. We list some potential recessive resistance genes that can be utilized in antiviral breeding and emphasize the importance and promise of recessive resistance gene-based antiviral breeding to generate transgene-free plants without developmental defects. Finally, we discuss the challenges and opportunities for the application of CRISPR/Cas techniques in the prevention and control of plant viruses in the field.

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“…Interestingly, HAT1 has also been linked to brassinosteroid (BR) signaling pathway. Recent work has demonstrated that HAT1, apart from its role in auxin-regulated cotyledon development (Figure 3), in BR-mediated growth responses [95], in GA signaling, and in viral defense response in a manner dependent on salicylic acid (SA) [101], it also negatively regulates, redundantly with HAT3, ABA-mediated drought responses through suppression of ABA biosynthesis and signaling [102]. Interestingly, the effect of ATHB17 on seedling growth in the presence of ABA is stage-specific.…”

Section: Hd-zips IImentioning

confidence: 99%

Multiple links between HD-Zip proteins and hormone networks

Sessa

Carabelli

Possenti

et al. 2018

Preprint

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HD-Zip proteins are unique to plants, and contain a homeodomain closely linked to a leucine zipper motif, which are involved in dimerization and DNA binding. Based on homology in the HD-Zip domain, gene structure and the presence of additional motifs, HD-Zips are divided into four families, HD-Zip I–IV. Phylogenetic and bioinformatics analysis of HD-Zip genes using transcriptomic and genomic datasets from a wide range of plant species indicate that the HD-Zip protein class was already present in green algae. Later, HD-Zips experienced multiple duplication events that promoted neo- and sub-functionalizations. HD-Zip proteins are known to control key developmental and environmental responses, and a growing body of evidence indicates a strict link between members of the HD-Zip II and III families and the auxin machineries. Interactions of HD-Zip proteins with other hormones such as brassinolide and cytokinin have also been described. However, it is striking that among the genes regulated by REV, a HD-Zip III protein playing a key role in apical development, are genes that mediate ABA signaling. Furthermore, HAT1 and HAT3, two HD-Zip II proteins involved in key developmental processes, repress ABA biosynthesis and signaling, indicating an essential role of these factors in adjusting development to changing environment.

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Role of Transcription Factor HAT1 in ModulatingArabidopsis thalianaResponse toCucumber mosaic virus

Cited by 28 publications

References 55 publications

Transcription factor HAT1 is a substrate of SnRK2.3 kinase and negatively regulates ABA synthesis and signaling in Arabidopsis responding to drought

Transcription factor HAT1 is a substrate of SnRK2.3 kinase and negatively regulates ABA synthesis and signaling in Arabidopsis responding to drought

Control of Plant Viruses by CRISPR/Cas System-Mediated Adaptive Immunity

Multiple links between HD-Zip proteins and hormone networks

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