Transcription factor HAT1 is a substrate of SnRK2.3 kinase and negatively regulates ABA synthesis and signaling in Arabidopsis responding to drought

Tan, Wenrong; Zhang, Dawei; Zhou, Huapeng; Zheng, Ting; Yin, Yanhai; Lin, Honghui

doi:10.1371/journal.pgen.1007336

Cited by 90 publications

(83 citation statements)

References 74 publications

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“…The areb1/areb2/abf3 triple mutant was sensitive to drought-stress and was more resistant to ABA (primary root growth) when compared with other single and double mutants, suggesting that ABF3, AREB1, and AREB2 are the master TFs that regulate the ABRE-dependent gene expression under stress conditions in ABA signaling. HD-ZIP transcription factor (TF), HAT1, a critical regulator in brassinosteroid (BR) signaling, interacts with SnRK2s [137,138]. HAT1 suppresses ABA signaling and is involved in ABA regulation of drought response [138], which also suggests the integration of BR signaling with ABA signaling to regulate the downstream targets of abiotic stress tolerance.…”

Section: Abiotic Stress Signaling Integration With the Aba Signaling mentioning

confidence: 99%

“…HD-ZIP transcription factor (TF), HAT1, a critical regulator in brassinosteroid (BR) signaling, interacts with SnRK2s [137,138]. HAT1 suppresses ABA signaling and is involved in ABA regulation of drought response [138], which also suggests the integration of BR signaling with ABA signaling to regulate the downstream targets of abiotic stress tolerance.…”

Section: Abiotic Stress Signaling Integration With the Aba Signaling mentioning

confidence: 99%

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Integration of Abscisic Acid Signaling with Other Signaling Pathways in Plant Stress Responses and Development

Kumar

Kesawat

Ali

et al. 2019

Plants

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Plants are immobile and, to overcome harsh environmental conditions such as drought, salt, and cold, they have evolved complex signaling pathways. Abscisic acid (ABA), an isoprenoid phytohormone, is a critical signaling mediator that regulates diverse biological processes in various organisms. Significant progress has been made in the determination and characterization of key ABA-mediated molecular factors involved in different stress responses, including stomatal closure and developmental processes, such as seed germination and bud dormancy. Since ABA signaling is a complex signaling network that integrates with other signaling pathways, the dissection of its intricate regulatory network is necessary to understand the function of essential regulatory genes involved in ABA signaling. In the present review, we focus on two aspects of ABA signaling. First, we examine the perception of the stress signal (abiotic and biotic) and the response network of ABA signaling components that transduce the signal to the downstream pathway to respond to stress tolerance, regulation of stomata, and ABA signaling component ubiquitination. Second, ABA signaling in plant development processes, such as lateral root growth regulation, seed germination, and flowering time regulation is investigated. Examining such diverse signal integration dynamics could enhance our understanding of the underlying genetic, biochemical, and molecular mechanisms of ABA signaling networks in plants. 592 2 of 20 and developmental stages, plants were experiencing drought stress [5,[9][10][11][12][13][14][15][16][17]. Therefore, ABA is a misnomer [18], even though it plays a role in leaf senescence and seed dormancy, potentially via osmotic effects [19][20][21]. It has been observed that drought-stressed vegetative tissues of numerous plants accumulate ABA (40-fold induction) within hours of osmotic stress and then it decreases after rehydration. In addition, ABA has been considered a long-distance stress signal between shoots and roots [22]. Therefore, the study of spatiotemporal expression of genes that control ABA metabolism's rate-limiting steps is essential for understanding how plants adapt to stress. Other than its role in adaptation to abiotic stress, ABA has been shown to be a key regulator of pathogen virulence [23][24][25][26][27], which could offer insights into the basis of the ABA-synthesizing ability of numerous bio-and necrotrophic microbes [24,[28][29][30].Gene products acting in the vicinity of the cell wall or at the interface of the plasma membrane/cytoskeleton/cell wall are considered the most likely elements to participate in initial stress perception. For instance, gated aquaporins (plasma membrane intrinsic proteins (PIPs)) and osmo-/ion channels at the cell wall-plasma membrane interface may be implicated in the upstream perception [31][32][33]. The receptor of ABA remained unknown until 2009. Before then, several ABA receptors had been reported [34][35][36][37][38][39][40]; however, further investigations did not substantiate any o...

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Section: Abiotic Stress Signaling Integration With the Aba Signaling mentioning

confidence: 99%

Section: Abiotic Stress Signaling Integration With the Aba Signaling mentioning

confidence: 99%

Integration of Abscisic Acid Signaling with Other Signaling Pathways in Plant Stress Responses and Development

Kumar

Kesawat

Ali

et al. 2019

Plants

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“…A rice zinc finger transcription factor was shown to negatively regulate stomatal closure by modulating genes for H 2 O 2 homeostasis (Huang et al, 2009). A recent report shows that the transcription factor HAT1 negatively regulates ABA synthesis and signaling in Arabidopsis in response to drought (Tan et al, 2018). AGL16 contributes one more means for plants to fine tune stomatal movement.…”

Section: Discussionmentioning

confidence: 99%

MADS-box factor AGL16 negatively regulates drought resistance via stomatal density and stomatal movement

Xiang

Zhao²,

Miao³

et al. 2019

Preprint

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Drought is one of the most severe environmental factors limiting plant growth and productivity. Plants respond to drought by closing stomata to reduce water loss.The molecular mechanisms underlying plant drought resistance are very complex and yet to be fully understood. While much research attention has been focused on the positive regulation of stomatal closure, less is known about its negative regulation, equally important in this reversible process. Here we show that the MADS-box transcriptional factor AGL16 acts as a negative regulator in drought resistance by regulating both stomatal density and movement. Loss-of-function mutant agl16 was more resistant to drought stress with higher relative water content, which was attributed to a reduced leaf stomatal density and more sensitive stomatal closure due to a higher leaf ABA level compared with wild type, while AGL16 overexpression lines displayed the opposite phenotypes. AGL16 is preferentially expressed in guard cells and down regulated in response to drought stress. The expression of CYP707A3 and AAO3 in ABA metabolism and SDD1 in stomatal development was altered by AGL16 as shown in agl16 and overexpression lines. Chromatin immunoprecipitation, transient transactivation, and yeast-one-hybrid assays demonstrated that AGL16 bound the CArG motif in the promoter of the CYP707A3, AAO3, and SDD1 to regulate their transcription, and therefore alter leaf stomatal density and ABA level.Taken together, AGL16 acts as a negative regulator of drought resistance by modulating leaf stomatal density and ABA accumulation.

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“…The areb1/areb2/abf3 triple mutant was sensitive to drought-stress and was more resistant to ABA (primary root growth) when compared with other single and double mutants, suggesting that ABF3, AREB1, and AREB2 are the master TFs that regulate the ABRE-dependent gene expression under stress conditions in ABA-signaling. HD-ZIP transcription factor, HAT1, a critical regulator in Brassinosteroid (BR) signaling, interacts with SnRK2s [121,122]. HAT1 suppresses ABA signaling and is involved in ABA regulation of drought response [122], which also suggests the integration of BR-signaling with ABA signaling to regulate the downstream targets of abiotic stress tolerance.…”

Section: Abiotic-stress Signaling Integration With the Aba Signaling mentioning

confidence: 99%

“…HD-ZIP transcription factor, HAT1, a critical regulator in Brassinosteroid (BR) signaling, interacts with SnRK2s [121,122]. HAT1 suppresses ABA signaling and is involved in ABA regulation of drought response [122], which also suggests the integration of BR-signaling with ABA signaling to regulate the downstream targets of abiotic stress tolerance.…”

Section: Abiotic-stress Signaling Integration With the Aba Signaling mentioning

confidence: 99%

Integration of Abscisic Acid Signaling with Other Signaling Pathways in Plant Stress Responses and Development

Kumar¹,

Kesawat²,

Ali³

et al. 2019

Preprint

View full text Add to dashboard Cite

Plants are immobile, and, to overcome harsh environmental conditions, such as drought, salt, and cold, they have evolved complex signaling pathways. Abscisic acid (ABA), an isoprenoid phytohormone, is a critical signaling mediator that regulates diverse biological processes in various organisms. Significant progress has been made in the determination and characterization of key ABA-mediated molecular factors involved in different stress responses, including stomatal closure and developmental processes, such as seed germination and bud dormancy. Since ABA-signaling is a complex signaling network that integrates with other signaling pathways, the dissection of its intricate regulatory network is necessary to understand the function of essential regulatory genes involved in ABA signaling. In the present review, we focus on two aspects of ABA signaling. First, the perception of the stress signal (abiotic and biotic) and the response network of ABA-signaling components that transduce the signal to the downstream pathway to respond to stress tolerance, regulation of stomata, and ABA signaling component ubiquitination. Second, ABA-signaling in plant development processes, such as lateral root growth regulation, seed germination, and flowering time regulation. Examining such diverse signal integration dynamics could enhance our understanding of the underlying genetic, biochemical, and molecular mechanisms of ABA signaling networks in plants.decreases after rehydration. In addition, ABA has been considered a long-distance stress signal between shoots and roots [22]. Therefore, the study of spatiotemporal expression of genes that control ABA metabolism rate-limiting steps is essential for understanding how plants adapt to stress. Other than its role in adaptation to abiotic stress, ABA has been shown to be a key regulator of pathogen-virulence [23][24][25][26][27], which could offer insights into the basis of the ABA-synthesizing ability of numerous bio-and necrotrophic microbes [24,[28][29][30].Gene products acting in the vicinity of the cell wall or at the interface of the plasma membrane/cytoskeleton/cell wall are considered the most likely elements to participate in initial stress perception. For instance, gated aquaporins (PIPs, plasma membrane intrinsic proteins) and osmo-/ion channels at the cell wall-plasma membrane interface may be implicated in the upstream perception [31][32][33]. The receptor of ABA remained unknown until 2009. Before 2009, several ABA receptors had been reported [34][35][36][37][38][39][40]; however, further investigations, did not substantiate any of them. In 2009, two independent studies reported the START (steroidogenic acute regulatory protein (StAR)-related lipid-transfer) domain of the significant Bet v1 (birch pollen allergen) superfamily of proteins as candidate ABA receptors [41][42][43][44]. All 14 members of the protein family are named Regulatory Component of ABA Receptor, RCAR1-RCAR14, [41], or Pyrabactin Resistance 1 and PYR1-like 1-13 [42]. The discovery of PYR1-like components ...

show abstract

Transcription factor HAT1 is a substrate of SnRK2.3 kinase and negatively regulates ABA synthesis and signaling in Arabidopsis responding to drought

Cited by 90 publications

References 74 publications

Integration of Abscisic Acid Signaling with Other Signaling Pathways in Plant Stress Responses and Development

Integration of Abscisic Acid Signaling with Other Signaling Pathways in Plant Stress Responses and Development

MADS-box factor AGL16 negatively regulates drought resistance via stomatal density and stomatal movement

Integration of Abscisic Acid Signaling with Other Signaling Pathways in Plant Stress Responses and Development

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