Role of topical antibiotic prophylaxis in prevention of bacterial translocation into upper trachea in nasally intubated patients undergoing tonsillectomies

Samra, Mohamed Abu; Bendary, Hanaa El; Hayes, Salwa M.S.; Elhadidy, Mona B.

doi:10.1016/j.ijporl.2012.11.018

Cited by 3 publications

(2 citation statements)

References 17 publications

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“…Both Spear-man correlation coefficient (Spear-man γ = 0.757) and Kappa analysis showed that the ETAs is highly correlated to the ETTs in general, with κ = 0.751. The partially inconsistency is possibly due to: (1) The uneven distribution of microbial colonies due to the limited movement and cough reflex of patients undergoing MV [12, 21], (2) Microbials have higher resistance to antibiotics when forming biofilm on ETTs than suspending in ETAs, causing the differences in the microbial component between ETAs and ETTs [10, 22].…”

Section: Discussionmentioning

confidence: 99%

Microbiological analysis of endotracheal aspirate and endotracheal tube cultures in mechanically ventilated patients

et al. 2019

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Background To compare the microbiological culture within endotracheal aspirate specimens (ETAs) and endotracheal tube specimens (ETTs) in patients undergoing mechanical ventilation (MV) by statistical tools. Method ETAs and ETTs from a total number of 81 patients, who were undergoing MV at the intensive care unit (ICU) of Jiading Central Hospital Affiliated Shanghai University of Medicine & Health Sciences from September 1st, 2017 to August 31st, 2018, were collected for microbiological culture analysis. Correlation of ETAs and ETTs cultures were obtained by Spear-men correlation analysis, while the consistency of the two specimens was determined by Kappa analysis and principal component analysis (PCA). Results Microbiological culture from both ETAs and ETTs showed that Acinetobacter baumannii , Pseudomonas aeruginosa , Staphylococcus aureus , and Klebsiella pneumoniae were the main pathogens, with Spear-man correlation coefficients of 0.676, 0.951, 0.730 and 0.687 respectively (all P < 0.01), and the overall Spear-man correlation coefficient is 0.757 (P < 0.01). This result shows that two samples were positively correlated. Kappa analysis also revealed high consistency of the microbial culture results from the ETAs and the ETTs (overall κ = 0.751, P < 0.01). The κ values for the four bacteria detected were 0.670, 0.949, 0.723, and 0.687, respectively (all P < 0.001). PCA also revealed high similarity. Conclusion Combining microbiological culture and statistical analysis of samples collected from 81 patients who were undergoing MV in ICU, we showed that microbe found in the ETAs had high similarity with that found in the ETTs which collected at the end of the catheters. In clinical practice, ETAs analysis is easily accessible meanwhile provides a valuable information for MV patients. Electronic supplementary material The online version of this article (10.1186/s12890-019-0926-3) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Microbiological analysis of endotracheal aspirate and endotracheal tube cultures in mechanically ventilated patients

et al. 2019

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“…Так, из числа пациентов, получавших топический бацитрацин и неомицин, только у 1 пациента на 3-и сут использования препарата стали появляться клинические признаки экзематизации (эритематозно-сквамозные элементы с микровезикуляцией и несколькими участками ГНОЙНЫЕ И ТРОФИЧЕСКИЕ ПОРАЖЕНИЯ [23]. В работе М. Abu Samra et al была продемонстрирована возможность с помощью такой топической антибактериальной комбинации снизить риск бактериальной контаминации верхних дыхательных путей при назальной интубации трахеи, что имеет важное значение для анестезиологической практики [24]. Эти и многие другие работы подчеркивают важность проведения дальнейших исследований, направленных на изучение возможностей этой антибактериальной комбинации.…”

Section: результаты исследованияunclassified

The possibility of using a topical combined antibacterial agent in the prevention of infection during surgical intervention

Жучков

Жучкова

Tarasenko

2019

Stacionarozameshchayushchie tekhnologii: Ambulatornaya khirurgi

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Microbial Composition and Antibiotic Resistance of Biofilms Recovered from Endotracheal Tubes of Mechanically Ventilated Patients

Vandecandelaere

Coenye

2014

Advances in Experimental Medicine and Biology

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In critically ill patients, breathing is impaired and mechanical ventilation, using an endotracheal tube (ET) connected to a ventilator, is necessary. Although mechanical ventilation is a life-saving procedure, it is not without risk. Because of several reasons, a biofilm often forms at the distal end of the ET and this biofilm is a persistent source of bacteria which can infect the lungs, causing ventilator-associated pneumonia (VAP). There is a link between the microbial flora of ET biofilms and the microorganisms involved in the onset of VAP. Culture dependent and independent techniques were already used to identify the microbial flora of ET biofilms and also, the antibiotic resistance of microorganisms obtained from ET biofilms was determined. The ESKAPE pathogens play a dominant role in the onset of VAP and these organisms were frequently identified in ET biofilms. Also, antibiotic resistant microorganisms were frequently present in ET biofilms. Members of the normal oral flora were also identified in ET biofilms but it is thought that these organisms initiate ET biofilm formation and are not directly involved in the development of VAP.

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Role of topical antibiotic prophylaxis in prevention of bacterial translocation into upper trachea in nasally intubated patients undergoing tonsillectomies

Cited by 3 publications

References 17 publications

Microbiological analysis of endotracheal aspirate and endotracheal tube cultures in mechanically ventilated patients

Microbiological analysis of endotracheal aspirate and endotracheal tube cultures in mechanically ventilated patients

The possibility of using a topical combined antibacterial agent in the prevention of infection during surgical intervention

Microbial Composition and Antibiotic Resistance of Biofilms Recovered from Endotracheal Tubes of Mechanically Ventilated Patients

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