Role of Toll-Like Receptors and Their Endogenous Ligands in the Pathogenesis of Rheumatoid Arthritis: A Review of Literature

The role of Toll-like receptors in neurobiology of alcoholism

“…The activity of TLRs depends on the level of exogenous and endogenous ligands by which these receptors are activated. Ethanol consumption is accompanied by an increase in the level of endogenous ligands, such as HMGB1 (7), heat shock proteins (49), proteins involved in extracellular matrix degradation (50), and various variants of microRNA (51)(52)(53)(54)(55). Endogenous ligands are released in response to the activation of the inflammatory process in the brain and during apoptotic cell damage in the central nervous system (3)(4)(5)(6)(7).…”

The different roles of toll-like receptors in oncotherapy

“…Стимуляция иммунного ответа на опухолевые антигены вследствие снижения толерантности к аутоантигенам позволила отнести лиганды ТПР к вакцинным адъювантам [26][27][28][29]. Стимулирующее действие ТПР неизбирательно и может распространяться на опухолевый процесс.…”