The Role of Toll-Like Receptors in Neuroimmunology of Alcoholism

Айрапетов, М. И.; Ереско, С. О.; Лебедев, А. А.; Bychkov, Eugenii R.; Shabanov, Petr D.

doi:10.1134/s1990750821010029

Cited by 2 publications

(2 citation statements)

References 61 publications

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“…In the CNS, various types of TLRs are present. Microglial cells express TLR1 through TLR9, neurons express TLR3, TLR4, TLR7, TLR8, and TLR9, astrocytes express TLR2, TLR3, and TLR9, while oligodendrocytes express TLR2 and TLR3 [143][144][145][146][147]. Interactions among microglia, neurons, astrocytes, and oligodendrocytes are pivotal in neuroimmune signaling, as highlighted by previous studies [146,263,264].…”

Section: Toll-like Receptor Signaling and Neuroimmune Regulationmentioning

confidence: 68%

Neuroactive Steroids, Toll-like Receptors, and Neuroimmune Regulation: Insights into Their Impact on Neuropsychiatric Disorders

Balan,

Boero,

Chéry

et al. 2024

Life

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Pregnane neuroactive steroids, notably allopregnanolone and pregnenolone, exhibit efficacy in mitigating inflammatory signals triggered by toll-like receptor (TLR) activation, thus attenuating the production of inflammatory factors. Clinical studies highlight their therapeutic potential, particularly in conditions like postpartum depression (PPD), where the FDA-approved compound brexanolone, an intravenous formulation of allopregnanolone, effectively suppresses TLR-mediated inflammatory pathways, predicting symptom improvement. Additionally, pregnane neurosteroids exhibit trophic and anti-inflammatory properties, stimulating the production of vital trophic proteins and anti-inflammatory factors. Androstane neuroactive steroids, including estrogens and androgens, along with dehydroepiandrosterone (DHEA), display diverse effects on TLR expression and activation. Notably, androstenediol (ADIOL), an androstane neurosteroid, emerges as a potent anti-inflammatory agent, promising for therapeutic interventions. The dysregulation of immune responses via TLR signaling alongside reduced levels of endogenous neurosteroids significantly contributes to symptom severity across various neuropsychiatric disorders. Neuroactive steroids, such as allopregnanolone, demonstrate efficacy in alleviating symptoms of various neuropsychiatric disorders and modulating neuroimmune responses, offering potential intervention avenues. This review emphasizes the significant therapeutic potential of neuroactive steroids in modulating TLR signaling pathways, particularly in addressing inflammatory processes associated with neuropsychiatric disorders. It advances our understanding of the complex interplay between neuroactive steroids and immune responses, paving the way for personalized treatment strategies tailored to individual needs and providing insights for future research aimed at unraveling the intricacies of neuropsychiatric disorders.

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Section: Toll-like Receptor Signaling and Neuroimmune Regulationmentioning

confidence: 68%

Neuroactive Steroids, Toll-like Receptors, and Neuroimmune Regulation: Insights into Their Impact on Neuropsychiatric Disorders

Balan,

Boero,

Chéry

et al. 2024

Life

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“…The difference between alcoholism and alcohol abuse is people of alcohol abuse are not physically dependent on alcohol [2]. Excessive alcohol use will damage all organ systems, but it mainly influences the heart, liver, brain, pancreas, and immune system [3]. Besides, alcoholism may cause schizophrenia, bipolar disorder, depression [4], irregular heartbeat [5], Wernicke-Korsakoff syndrome [6], etc.…”

Section: Introductionmentioning

confidence: 99%

VISPNN: VGG-Inspired Stochastic Pooling Neural Network

Wang¹,

Khan²,

Zhang³

2022

Computers, Materials &Amp; Continua

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Aim Alcoholism is a disease that a patient becomes dependent or addicted to alcohol. This paper aims to design a novel artificial intelligence model that can recognize alcoholism more accurately. Methods We propose the VGG-Inspired stochastic pooling neural network (VISPNN) model based on three components: (i) a VGG-inspired mainstay network, (ii) the stochastic pooling technique, which aims to outperform traditional max pooling and average pooling, and (iii) an improved 20-way data augmentation (Gaussian noise, salt-and-pepper noise, speckle noise, Poisson noise, horizontal shear, vertical shear, rotation, Gamma correction, random translation, and scaling on both raw image and its horizontally mirrored image). In addition, two networks (Net-I and Net-II) are proposed in ablation studies. Net-I is based on VISPNN by replacing stochastic pooling with ordinary max pooling. Net-II removes the 20-way data augmentation. Results The results by ten runs of 10-fold cross-validation show that our VISPNN model gains a sensitivity of 97.98

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The Role of Toll-Like Receptors in Neuroimmunology of Alcoholism

Cited by 2 publications

References 61 publications

Neuroactive Steroids, Toll-like Receptors, and Neuroimmune Regulation: Insights into Their Impact on Neuropsychiatric Disorders

Neuroactive Steroids, Toll-like Receptors, and Neuroimmune Regulation: Insights into Their Impact on Neuropsychiatric Disorders

VISPNN: VGG-Inspired Stochastic Pooling Neural Network

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