Role of TLRs in the production of chemical mediators in nasal polyp fibroblasts by fungi

Shin, Seung‐Heon; Ye, Mi‐Kyung; Kim, Yee-Hyuk; Kim, Jeong‐Kyu

doi:10.1016/j.anl.2015.07.003

Cited by 15 publications

(11 citation statements)

References 13 publications

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“…Anti-inflammatory properties of BV for treating skin disease, neurodegenerative disease, and joint diseases have been commonly studied, and these anti-inflammatory effects are associated with decreased expression of TLRs, chemical mediators, nitric oxides, and phosphorylation of inflammatory transcription factors [ 7 ]. According to the previous study, Alternaria induces the production of chemical mediators through TLR 2 and TLR5 [ 16 ]. Although we do not know the action mechanism of apamin and melittin, they may not influence the expression of TLR2 or 5 or the concentration of melittin used in this study may not enough to suppress the production of chemical mediators from nasal fibroblasts.…”

Section: Discussionmentioning

confidence: 99%

The Effects of Melittin and Apamin on Airborne Fungi-Induced Chemical Mediator and Extracellular Matrix Production from Nasal Polyp Fibroblasts

Shin

Choi

et al. 2017

Toxins

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Melittin and apamin are the main components of bee venom and they have been known to have anti-inflammatory and anti-fibrotic properties. The aim of this study was to evaluate the effect of melittin and apamin on airborne fungi-induced chemical mediator and extracellular matrix (ECM) production in nasal fibroblasts. Primary nasal fibroblasts were isolated from nasal polyps, which were collected during endoscopic sinus surgery. Nasal fibroblasts were treated with Alternaria and Aspergillus. The effects of melittin and apamin on the production of interleukin (IL)-6 and IL-8 were determined with enzyme linked immunosorbent assay. ECM mRNA and protein expressions were determined with the use of quantitative RT-PCR and Western blot. Alternaria-induced IL-6 and IL-8 production was significantly inhibited by apamin. However, melittin did not influence the production of IL-6 and IL-8 from nasal fibroblasts. Melittin or apamin significantly inhibited collagen type I, TIMP-1, and MMP-9 mRNA expression and protein production from nasal fibroblasts. Melittin and apamin inhibited Alternaria-induced phosphorylation of Smad 2/3 and p38 MAPK. Melittin and apamin can inhibit the fungi-induced production of chemical mediators and ECM from nasal fibroblasts. These results suggest the possible role of melittin and apamin in the treatment of fungi induced airway inflammatory diseases.

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Section: Discussionmentioning

confidence: 99%

The Effects of Melittin and Apamin on Airborne Fungi-Induced Chemical Mediator and Extracellular Matrix Production from Nasal Polyp Fibroblasts

Shin

Choi

et al. 2017

Toxins

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“…Studies on polyp and control tissue show that increased epithelial TLR2 (Sun et al, 2012) and TLR4 may be related with CRSwNP (Sun et al, 2012;Shimizu et al, 2016;Hu and Li, 2018). Nasal polyp fibroblast activation may occur via TLR2 (Shin et al, 2016a,b;Tsai et al, 2018), TLR4 (Cho et al, 2014(Cho et al, , 2016, TLR5 (Shin et al, 2016b), and TLR9 (Park et al, 2018) might be related to polyp B-cell activation (Xu et al, 2014). NOD family PRRs form a major component of the inflammasome, and are related in programmed pro-inflammatory cell death distinct from apoptosis.…”

Section: Upper Airway Epithelial Functions During Ar and Crsmentioning

confidence: 99%

Airway Epithelial Dynamics in Allergy and Related Chronic Inflammatory Airway Diseases

Laulajainen‐Hongisto

Toppila‐Salmi

Luukkainen

et al. 2020

Front. Cell Dev. Biol.

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Allergic rhinitis, chronic rhinosinusitis, and asthma are highly prevalent, multifactorial chronic airway diseases. Several environmental and genetic factors affect airway epithelial dynamics leading to activation of inflammatory mechanisms in the airways. This review links environmental factors to host epithelial immunity in airway diseases. Understanding altered homeostasis of the airway epithelium might provide important targets for diagnostics and therapy of chronic airway diseases.

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“…Moreover, it has been shown that both IL-6 and the Th2 cytokines IL-4 and IL-5 are more strongly expressed in patients with allergic rhinitis [ 93 , 94 ]. Interestingly, IL-6 was more highly expressed in nasal polyps in allergic individuals than in nasal polyps in non-allergic individuals [ 92 , 95 ], suggesting that IL-6 and the IL-6 signaling pathway could play a potential role in CRSwNP in patients with inhalation allergies. Furthermore, studies on the pathogenesis of nasal polyps have not demonstrated a link to elevated TNF-β as yet.…”

Section: Comorbidities Of Crsmentioning

confidence: 99%

Subtyping of polyposis nasi: phenotypes, endotypes and comorbidities

et al. 2018

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BackgroundChronic rhinosinusitis (CRS) is a heterogeneous, multifactorial inflammatory disease of the nasal and paranasal mucosa. It has not been possible to date to develop an internationally standardized, uniform classification for this disorder. A phenotype classification according to CRS with (CRSwNP) and without polyposis (CRSsNP) is usually made. However, a large number of studies have shown that there are also different endotypes of CRS within these phenotypes, with different pathophysiologies of chronic inflammation of the nasal mucosa. This review describes the central immunological processes in nasal polyps, as well as the impact of related diseases on the inflammatory profile of nasal polyps.Materials and methodsThe current knowledge on the immunological and molecular processes of CRS, in particular CRSwNP and its classification into specific endotypes, was put together by means of a structured literature search in Medline, PubMed, the national and international guideline registers, and the Cochrane Library.ResultsBased on the current literature, the different immunological processes in CRS and nasal polyps were elaborated and a graphical representation in the form of an immunological network developed. In addition, different inflammatory profiles can be found in CRSwNP depending on related diseases, such as bronchial asthma, cystic fibrosis (CF), or NASID-Exacerbated Respiratory Disease (N‑ERD).ConclusionThe identification of different endotypes of CRSwNP may help to improve diagnostics and develop novel individual treatment approaches in CRSwNP.

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Role of TLRs in the production of chemical mediators in nasal polyp fibroblasts by fungi

Cited by 15 publications

References 13 publications

The Effects of Melittin and Apamin on Airborne Fungi-Induced Chemical Mediator and Extracellular Matrix Production from Nasal Polyp Fibroblasts

The Effects of Melittin and Apamin on Airborne Fungi-Induced Chemical Mediator and Extracellular Matrix Production from Nasal Polyp Fibroblasts

Airway Epithelial Dynamics in Allergy and Related Chronic Inflammatory Airway Diseases

Subtyping of polyposis nasi: phenotypes, endotypes and comorbidities

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