Role of Thymus Oil in Burn Wound Healing

Abstract

Thymus oil and its components are becoming increasingly popular as naturally occurring antimicrobial and antioxidant agents. The real importance of thymus on nitric oxide (NO) is unknown. NO is an important mediator in numerous physiologic and pathophysiologic events. Stasis and thrombosis in burn wound can progress as a result of the release of local mediators. The implication of NO in burn injury is not well studied. In this study, we tried to determine the role of burn-induced NO and whether thymus oil plays a protective role after a thermal injury. Rats were divided into five groups. We topically applied thymus oil, olive oil, and silverdin and sulfadiazine on the rats, respectively, during a period of 21 days after they were burned while under anesthesia. The burned control group and nonburned control group did not receive any treatment. The results of this study show that NO was overproduced by thermal injury and decreased during the days after burn injury. The decrease in rats treated with thymus and sulfadiazine was higher than the others. These data indicate that thymus oil may serve as a protective agent to the damaged tissues by decreasing the NO level. Histologic examination results show that the formation of new tissue in rats receiving thymus oil was more than other burned groups, and this finding supports our hypothesis.

Evaluation of Thymus vulgaris Extract on Hippocampal Injury Induced by Transient Global Cerebral Ischemia and Reperfusion in Rat

“…In Dursun et al (2003) study treatment of rats with Thymus vulgaris extract decreased amount of nitric oxide produced after burn injury. They suggested that thyme extract may serve as a protective agent to the damaged tissues by decreasing the NO level [33].…”

“…They suggested that thyme extract may serve as a protective agent to the damaged tissues by decreasing the NO level [33]. Meeran et al (2012) evaluates the protective effects of thymol (a main component of thyme oil) on plasma lipid peroxidation.…”

Chemical composition and antitumor activity of different wild varieties of Moroccan thyme

“…Our results are in agreement with those of (Salmenova et al, 2007) and (Braga et al, 2006) who reported that thymol has an antioxidant and antitumor effect. In the other hand, essential oil of thyme can have preventive effect opposite to cancer by the means of antioxidant properties of its components (Dursun et al, 1999;Lee;Shibamoto, 2002;Youdim;Deans, 2000).…”

Comparison of the Efficacy of Honey and Animal Oil in Accelerating Healing of Full Thickness Wound of mice skin

“…Several studies have demonstrated improved wound healing with traditional medicinal oils treatment (Dursun et al, 2003;Kietzmann & Braun, 2006;Pei et al, 2006;.…”