Role of thymol on hyperglycemia and hyperlipidemia in high fat diet-induced type 2 diabetic C57BL/6J mice

Saravanan, S.; Pari, Leelavinothan

doi:10.1016/j.ejphar.2015.05.034

Cited by 94 publications

(53 citation statements)

References 51 publications

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“…In consistent with these studies, thymol or Thymus species (T. serpyllum) exhibit great potential as an anti-hyperglycemic agent in in vivo assays 68,69 . From these findings, Thymus species may be valuable to control postprandial hyperglycaemia for type 2 diabetes management.…”

Section: A-amylase and A-glucosidase Inhibitionsupporting

confidence: 49%

GC-MS analysis and in vitro antioxidant and enzyme inhibitory activities of essential oil from aerial parts of endemic Thymus spathulifolius Hausskn. et Velen

Ceylan

Zengin

Uysal

et al. 2015

Journal of Enzyme Inhibition and Medicinal Chemistry

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We investigated the antioxidant and enzyme inhibitory activities and chemical composition of the hydro-distilled essential oil (0.35% yield) from aerial parts of Thymus spathulifolius. Antioxidant capacity of the oil was assessed by different methods including free radical scavenging (DPPH and ABTS), reducing power (FRAP and CUPRAC) and phosphomolybdenum assay. Inhibitory activities were analyzed against acetylcholinesterase (AChE), butyrylcholinesterase (BChE), a-amylase, a-glucosidase, and tyrosinase. Twenty-one constituents were identified representing 97.2% of the total oil with thymol (50.5%), borneol (16.7%) and carvacrol (7.7%) as the major components. The essential oil exhibited good antioxidant activity with IC 50 values of 3.82 and 0.22 mg/mL determined by free radical scavenging DPPH and ABTS, respectively. EC 50 values of FRAP and CUPRAC were found to be 0.12 and 0.34 mg/mL, respectively. The results of the present study support the uses of T. spathulifolius essential oil as a source of natural antioxidants and bioactivities for functional foods and phytomedicines.

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Section: A-amylase and A-glucosidase Inhibitionsupporting

confidence: 49%

GC-MS analysis and in vitro antioxidant and enzyme inhibitory activities of essential oil from aerial parts of endemic Thymus spathulifolius Hausskn. et Velen

Ceylan

Zengin

Uysal

et al. 2015

Journal of Enzyme Inhibition and Medicinal Chemistry

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“…Generally, several essential oils found in plants were reported to have anti-diabetic activities [15]. Thymol, a monoterpene phenol, exhibited promising anti-diabetic activity [16] and isolongifolene, a sesquiterpenes, was reported to have antioxidant properties which might be helpful to prevent the progress of oxidative stress related to diabetes [17]. β-Eudesmol, a sesquiterpenoid alcohol, potentiates the neuromuscular blocking effect in phrenic nerve-diaphragm muscle preparations of normal and alloxan-diabetic mice [18].…”

Section: Gc-ms Analysis Of Fractionsmentioning

confidence: 99%

<i>In Vitro</i> Anti-Diabetic Activities and Phytochemical Analysis of Bioactive Fractions Present in <i>Meriandra dianthera, Aloe camperi</i> and a Polyherb

Sium¹,

Kareru²,

Kiage-Mokua³

et al. 2017

AJPS

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This paper reports the in vitro anti-diabetic profile of certain medicinal plants traditionally used in Eritrea for the management of type 2 diabetes. The crude methanolic extracts and fractions of Meriandra dianthera, Aloe camperi, a Polyherb and their fractions were investigated. The in vitro screening of the crude extracts has generally elicited a dose dependent α-glucosidase and α-amylase inhibition activities. M. dianthera displayed the highest α-glucosidase inhibitory activity (IC 50 : 0.074 ± 0.032 mg/mL) at the highest concentration tested (0.800 mg/mL) relative to A. camperi, the Polyherb and Acarbose (IC 50 : 0.37 ± 0.052, 0.56 ± 0.024 and 0.55 ± 0.029 respectively). The α-glucosidase inhibition activities of A. camperi and M. dianthera, except for the Polyherb and Acarbose, were significantly different (P < 0.05) at various ranges of concentrations (0.025 -0.800 mg/mL). The percentage α-amylase inhibitions of M. dianthera, A. camperi, the Polyherb and Acarbose, at the highest concentrations (0.800 mg/mL), were 78.3%, 15.9%, 16.4%, and 82.9% respectively. A. camperi and the Polyherb displayed lower α-amylase inhibitory activities (IC 50 :1.72 ± 0.06 and 2.57 ± 0.07 mg/mL respectively) compared to Acarbose and M. dianthera (IC 50 : 0.31 ± 0.01 and 0.43 ± 0.02 mg/mL respectively). For the α-amylase inhibition activity, even at lower concentrations (0.025 mg/mL), there were statistically significant differences (P < 0.01) among the values generated for all the extracts. The in vitro anti-diabetic screening of the fractions, at 0.800 mg/ml, displayed characteristic enzyme inhibition activities.How to cite this paper: Sium, M., Kareru, P., Kiage-Mokua, B., Sood, K., Langley, J. 534Generally, the non-polar fractions showed higher enzyme inhibitory activities compared to the polar fractions. The most bioactive non-polar fractions, thus, were subjected to GC-MS analysis and presented various essential oils, fatty acid methyl esters (FAMEs) and benzoic acid derivatives in those plants.

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“…There are numerous reports on the effects of a high-fat diet (HFD) intake on health, and the most serious and important are dyslipidaemia, which is characterised by hypertriglyceridaemia, hypercholesterolaemia, and fatty liver (3,4).…”

mentioning

confidence: 99%

Beneficial Effect of Bis(Hinokitiolato)Zn Complex on High-fat Diet-induced Lipid Accumulation in Mouse Liver and Kidney

Naito

Yoshikawa

Yoshizawa

et al. 2017

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Abstract. Background/Aim: Metabolic syndrome-induced lifestyle-related diseases include diabetes mellitus (DM) and hypertension, and Zn-based compounds have effects on DM. We aimed to investigate the ameliorating effects of bis(hinokitiolato) Zn, [Zn(hkt) 2 The westernization of eating habits has increased the intake of fat. Metabolic syndrome, which is caused by these changing dietary habits, induces diabetes mellitus (DM) or hypertension (1, 2). There are numerous reports on the effects of a high-fat diet (HFD) intake on health, and the most serious and important are dyslipidaemia, which is characterised by hypertriglyceridaemia, hypercholesterolaemia, and fatty liver (3, 4).Numerous researchers have reported the effects of many organic or inorganic compounds on various organs, leading to disorders such as fatty liver or diabetic nephropathy (5, 6). Furthermore, other studies have reported that some compounds, even known as beneficial food materials, can worsen a disease condition (7,8). These reports suggest that careful considerations are required to understand the correct use of these food materials and evaluate their effects on both biochemical parameters and organ morphology. In particular, dyslipidaemia, which is a risk factor for cardiovascular disease, should be prevented.Pioglitazone is known to exhibit efficacy in the treatment of DM owing to its blood glucose lowering, glycated haemoglobin (HbA1c) improvement, and glucose tolerance ameliorating effects (9, 10). Furthermore, numerous researchers have reported the anti-DM effect of Zn in in vivo experiments (11-13). For example, Zn compound 1) increased Akt-phosphorylation, as well as inhibited tyrosine-protein phosphatase non-receptor type 1B (PTP1B) and phosphatase and tensin homolog (PTEN) in 3T3-L1 adipocytes; and 2) inhibited alpha-glucosidase and 3) activated phosphodiesterase (14-18). Furthermore, only a few studies such as that of Moroki et al. (19) have reported experiments showing the effects of Zn complexes on lipid metabolism. Thus, the effects of Zn compounds on lipid metabolism have not been sufficiently examined yet.The experimental animals were fed an HFD or highfructose diet to establish the metabolic syndrome or DM model (20,21). Therefore, this study examined the histopathology of the livers and kidneys of C57BL/6J mice 1145

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Role of thymol on hyperglycemia and hyperlipidemia in high fat diet-induced type 2 diabetic C57BL/6J mice

Cited by 94 publications

References 51 publications

GC-MS analysis and in vitro antioxidant and enzyme inhibitory activities of essential oil from aerial parts of endemic Thymus spathulifolius Hausskn. et Velen

GC-MS analysis and in vitro antioxidant and enzyme inhibitory activities of essential oil from aerial parts of endemic Thymus spathulifolius Hausskn. et Velen

<i>In Vitro</i> Anti-Diabetic Activities and Phytochemical Analysis of Bioactive Fractions Present in <i>Meriandra dianthera, Aloe camperi</i> and a Polyherb

Beneficial Effect of Bis(Hinokitiolato)Zn Complex on High-fat Diet-induced Lipid Accumulation in Mouse Liver and Kidney

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Role of thymol on hyperglycemia and hyperlipidemia in high fat diet-induced type 2 diabetic C57BL/6J mice

Cited by 94 publications

References 51 publications

GC-MS analysis and in vitro antioxidant and enzyme inhibitory activities of essential oil from aerial parts of endemic Thymus spathulifolius Hausskn. et Velen

GC-MS analysis and in vitro antioxidant and enzyme inhibitory activities of essential oil from aerial parts of endemic Thymus spathulifolius Hausskn. et Velen

&lt;i&gt;In Vitro&lt;/i&gt; Anti-Diabetic Activities and Phytochemical Analysis of Bioactive Fractions Present in &lt;i&gt;Meriandra dianthera, Aloe camperi&lt;/i&gt; and a Polyherb

Beneficial Effect of Bis(Hinokitiolato)Zn Complex on High-fat Diet-induced Lipid Accumulation in Mouse Liver and Kidney

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Product

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<i>In Vitro</i> Anti-Diabetic Activities and Phytochemical Analysis of Bioactive Fractions Present in <i>Meriandra dianthera, Aloe camperi</i> and a Polyherb