Beneficial Effect of Bis(Hinokitiolato)Zn Complex on High-fat Diet-induced Lipid Accumulation in Mouse Liver and Kidney

Abstract

Abstract. Background/Aim: Metabolic syndrome-induced lifestyle-related diseases include diabetes mellitus (DM) and hypertension, and Zn-based compounds have effects on DM. We aimed to investigate the ameliorating effects of bis(hinokitiolato) Zn, [Zn(hkt) 2 The westernization of eating habits has increased the intake of fat. Metabolic syndrome, which is caused by these changing dietary habits, induces diabetes mellitus (DM) or hypertension (1, 2). There are numerous reports on the effects of a high-fat diet (HFD) intake on health, and the most serious and important are dyslipidaemia, which is characterised by hypertriglyceridaemia, hypercholesterolaemia, and fatty liver (3, 4).Numerous researchers have reported the effects of many organic or inorganic compounds on various organs, leading to disorders such as fatty liver or diabetic nephropathy (5, 6). Furthermore, other studies have reported that some compounds, even known as beneficial food materials, can worsen a disease condition (7,8). These reports suggest that careful considerations are required to understand the correct use of these food materials and evaluate their effects on both biochemical parameters and organ morphology. In particular, dyslipidaemia, which is a risk factor for cardiovascular disease, should be prevented.Pioglitazone is known to exhibit efficacy in the treatment of DM owing to its blood glucose lowering, glycated haemoglobin (HbA1c) improvement, and glucose tolerance ameliorating effects (9, 10). Furthermore, numerous researchers have reported the anti-DM effect of Zn in in vivo experiments (11-13). For example, Zn compound 1) increased Akt-phosphorylation, as well as inhibited tyrosine-protein phosphatase non-receptor type 1B (PTP1B) and phosphatase and tensin homolog (PTEN) in 3T3-L1 adipocytes; and 2) inhibited alpha-glucosidase and 3) activated phosphodiesterase (14-18). Furthermore, only a few studies such as that of Moroki et al. (19) have reported experiments showing the effects of Zn complexes on lipid metabolism. Thus, the effects of Zn compounds on lipid metabolism have not been sufficiently examined yet.The experimental animals were fed an HFD or highfructose diet to establish the metabolic syndrome or DM model (20,21). Therefore, this study examined the histopathology of the livers and kidneys of C57BL/6J mice 1145

Association Between Dietary Zinc Intake and Metabolic Syndrome. A Meta-Analysis of Observational Studies

“…Moreover, zinc supplementation also leads to a higher level of TNF-α bound monocytes, which may benefit the immune response system (37). On the other hand, some fundamental experimental evidence indicates that long term zinc supplementation directly improves MetS in animal model (38), and decreases several metabolic disorder makers, lipid accumulation, and toxicity (39)(40)(41). Above all, the existing clinical and experimental data are strongly consistent with our results.…”

Exercise Performance Upregulatory Effect of R-α-Lipoic Acid with γ-Cyclodextrin

“…Standard curve was plotted by preparing 1000 μg/mL (ppm) standard solution of Fe (Fujifilm Wako Pure Chemical Industries Ltd., Osaka, Japan) and diluting it in 5% ( v / v ) HNO 3 to the final metal concentrations of 0, 1, 5, 10, 50, 100, and 500 ng/mL (ppb). For quality control, 1 ng/mL (ppb) of the reference internal standard, indium (In), was measured along with the sample [ 30 ].…”