Cell Membranes 1984
DOI: 10.1007/978-1-4684-4823-8_7
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Role of the β-Adrenergic Receptor in the Regulation of Adenylate Cyclase

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1984
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Cited by 19 publications
(13 citation statements)
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“…$49 murine lymphoma cells which possess ~-adrenergic receptors coupled to adenylyl cyclase via Gs (see [33]) were used to examine the functional consequences of RM treatment. Isoproterenol-dependent activation of Gs mediated by the fl-adrenergic receptor was inhibited by RM in a concentration-dependent fashion in membranes of wild-type $49 murine lymphoma cells with an ICs0 value of approx.…”
Section: Resultsmentioning
confidence: 99%
“…$49 murine lymphoma cells which possess ~-adrenergic receptors coupled to adenylyl cyclase via Gs (see [33]) were used to examine the functional consequences of RM treatment. Isoproterenol-dependent activation of Gs mediated by the fl-adrenergic receptor was inhibited by RM in a concentration-dependent fashion in membranes of wild-type $49 murine lymphoma cells with an ICs0 value of approx.…”
Section: Resultsmentioning
confidence: 99%
“…Because both proteins act by regulating GTP-binding proteins, a compact structure based on seven membrane-spanning regions may be a general model for receptors that act on G proteins. (1). Functionally, the receptor is phylogenetically conserved.…”
mentioning
confidence: 99%
“…Activated G, can then bind to adenylate cyclase and stimulate its activity (see ref. 1 for review). The ,B-adrenergic receptor is thus a member of an even larger class of cell surface receptors that regulate the functions of multiple GTP-binding regulatory proteins, or G proteins.…”
mentioning
confidence: 99%
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“…*3-;='GTPyS * Gw + (3 Mg2+ Gi,0. (+ GTPyS GTPyS QGa j *' GTPyS 0* Gi+ (3 The obvious next question was to determine which of the subunits was responsible for the characteristic effects ofthe "activated" dimer. Resolution of the subunits can be achieved by high-performance gel filtration, and it was then determined that GTPzyS -G. was the necessary and sufficient activator of C. The (-subunit of G, thus acts as an inhibitor of activation and as a stimulator of deactivation by promoting formation of the G, dimer.…”
mentioning
confidence: 99%