Role of the inflammasome in chronic obstructive pulmonary disease (COPD)

Colarusso, Chiara; Terlizzi, Michela; Molino, Antonio; Pinto, Aldo; Sorrentino, Rosalinda

doi:10.18632/oncotarget.17850

Cited by 71 publications

(77 citation statements)

References 72 publications

(117 reference statements)

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“…Trials of low‐dose macrolides have demonstrated clinical benefit with a reduction in pulmonary exacerbations, increased time to next exacerbation and improved quality of life. Patients who are not actively smoking appear to gain greater benefit, possibly reflecting persistence of autoinflammation in the absence of a primary trigger , . These data support the notion that COPD is towards the autoinflammatory end of the IDC and that established COPD has an intrinsic priming of the innate IL‐1 β cytokine pathway.…”

Section: Chronic Obstructive Pulmonary Diseasesupporting

confidence: 61%

Autoinflammatory disease in the lung

et al. 2018

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Ascertaining the dominant cell type driving an immunological disease is essential to understanding the causal pathology and, therefore, selecting or developing an effective treatment. Classifying immunological diseases in this way has led to successful treatment regimens for many monogenic diseases; however, when the dominant cell type is unclear and there is no obvious causal genetic mutation, then identifying the correct disease classification and appropriate therapy can be challenging. In this review we focus on pulmonary immunological diseases where an innate immune signature has been identified as a predominant aspect of the immunopathology. We describe the molecular pathology of 'autoinflammatory diseases of the lung' and propose that small molecule and biological therapies, including recombinant interleukin-1 receptor antagonist, that target key innate immune pathways, are likely be beneficial in the control of pulmonary and systemic inflammation in these conditions. In addition, the successful use of macrolide antibiotics to treat lung infections in these conditions further confirms that the innate immune system is the key conductor of inflammation in these pulmonary diseases, as there is a strong body of evidence that macrolides are able to modulate the NLRP3 inflammasome and interleukin-1β and interleukin-18 secretion, both of which are central players in the innate immune response. Throughout this review we highlight the published evidence of autoinflammatory disease in chronic obstructive pulmonary disease, bronchiectasis, cystic fibrosis and rheumatoid lung disease and suggest that the fundamental pathology of these diseases places them towards the autoinflammatory pole of the immunological disease continuum.

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Section: Chronic Obstructive Pulmonary Diseasesupporting

confidence: 61%

Autoinflammatory disease in the lung

et al. 2018

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“…Oxidative stress and inflammation are two closely related conditions. Indeed, the overproduction of ROS triggers NF-κB and histone acetyltransferase activation, promoting the expression of inflammatory genes and consequently the production of inflammatory cytokines [49].…”

Section: Cigarette Smoke and Biomarkers Inflammationmentioning

confidence: 99%

Effects of Smoking on Oxidative Stress and Vascular Function

Carnevale¹,

Cammisotto²,

Pagano³

et al. 2018

Smoking Prevention and Cessation

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Tobacco smoking is the single most preventable risk factor related to the development of cardiovascular disease. It was demonstrated that tobacco smoke contains a thousand compounds potentially harmful to human health. As tobacco use declined over time, electronic cigarettes were introduced as an alternative. E-cigarettes are a modern and technological surrogate of traditional cigarettes and use heat to convert a nicotine solution or a flavored nicotine-free solution into vapor. Even though all the ingredients contained in the liquid of E-cigarettes are approved as food additives, the harmlessness of these electronic devices is still not fully proven in humans. The general mechanisms by which smoking results in cardiovascular events include the development of atherosclerotic changes with a hypercoagulable state and an increased risk of thrombosis. Endothelial dysfunction has been recognized as a hallmark of preclinical systemic atherosclerosis and as a useful marker to stratify the risk of cardiovascular disease. Based on these considerations, in this chapter, we (1) discussed the role of endothelial dysfunction and its contributing factors, such as oxidative stress and inflammation, in the development of cardiovascular diseases and (2) reported the studies which investigated the effect of tobacco and electronic smoking on the biomarkers of endothelial dysfunction, oxidative stress, and inflammation.

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“…[5][6][7][8] Some diseases are congenital, such as cystic fibrosis, whereas others can be acquired through smoking, such as COPD. 9,10 Lung transplantation is an established intervention for patients with advanced and life-threatening respiratory disease for which standard medical treatment is no longer effective or for which there is no effective standard medical treatment. 11 Three diseases that often necessitate lung transplantation are COPD, interstitial lung disease, and cystic fibrosis.…”

Section: Introductionmentioning

confidence: 99%

Experiences of Individuals Awaiting Lung Transplantation

2018

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Lung transplantation is an established intervention for patients with advanced and life-threatening respiratory disease. Unfortunately, the shortage of organ donors results in a need for organs that greatly exceeds availability. This narrative review aimed to investigate the experiences of patients with respiratory diseases who wait for lung transplantation. Articles were retrieved from medical literature databases. Thirteen qualitative studies were reviewed, one of them used a mixed method. We found that individuals faced varied and complex situations differently while waiting for lung transplantations, depending on physical, psychological, social, and existential factors. Waiting gives hope for a future without the limitations imposed by the disease but also causes great stress. Many individuals struggled with the existential guilt associated with the privilege of having access to transplantation. This review highlighted that support from health-care professionals, next of kin, patients who had previously received a transplantation, and close friends have a vital role to play for individuals waiting for a lung transplantation.

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Role of the inflammasome in chronic obstructive pulmonary disease (COPD)

Cited by 71 publications

References 72 publications

Autoinflammatory disease in the lung

Autoinflammatory disease in the lung

Effects of Smoking on Oxidative Stress and Vascular Function

Experiences of Individuals Awaiting Lung Transplantation

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