Role of the endometrial tripod interleukin-18, -15, and -12 in inadequate uterine receptivity in patients with a history of repeated in vitro fertilization–embryo transfer failure

Lédée-Bataille, Nathalie; Bonnet-Chea, K.; Hosny, Ghada; Dubanchet, Sylvie; Frydman, René; Chaouat, Gérard

doi:10.1016/j.fertnstert.2004.11.021

Cited by 141 publications

(68 citation statements)

References 27 publications

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“…Conversely, imbalances in these parameters correlate with implantation failure or early pregnancy loss (Ledee-Bataille et al, 2005). Their expression controls the local recruitment of CD56+ uNK cells and associated sub-endometrial angiogenesis, as reflected by the endometrial vascular flow index determined by three-dimensional ultrasound (Ledee et al, 2008a,b).…”

Section: Endometrial Uterine Receptivity: Vascular Remodeling and Thementioning

confidence: 99%

New pre-conception immune biomarkers for clinical practice: interleukin-18, interleukin-15 and TWEAK on the endometrial side, G-CSF on the follicular side

Lédée

Petitbarat

Rahmati

et al. 2011

Journal of Reproductive Immunology

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a b s t r a c tIdentification of biomarkers of optimal uterine receptivity to the implanting embryo as well as biomarkers of oocyte competence would undoubtedly improve the efficiency of assisted reproductive technology (ART). Expression of IL-15 and IL-18 has been shown to be different in patients with failed implantation after IVF/ICSI compared with fertile controls and both correlate with local uNK (CD56+) recruitment and angiogenesis. Tumor necrosis factor weak inducer of apoptosis (TWEAK) has been described in mice as a potent early immune regulator able to protect the conceptus. The results of our studies in human suggest that TWEAK modulates the IL-18 related cytotoxicity of uNK cells. Quantification of IL-18, TWEAK and IL-15 mRNA expression by real-time PCR in endometrial tissue collected in midluteal phase of non-conception cycles allowed documentation of physiological events that occur at the time of uterine receptivity. Such information may be useful for the physician especially in patients where embryos fail to implant. Cytokine quantification may assist in understanding the mechanisms leading to repeated IVF/ICSI failure: either depletion of cytokines necessary for the apposition-adhesion, or an excess of cytokines leading to local cytotoxicity, may impair the implantation of the embryo. Other new data suggest that a pre-conception dialogue mediated by the oocyte and the follicular fluid and the oocyte may contribute to later implantation success. Follicular concentration of G-CSF appears as a useful biomarker of oocyte competence before fertilization. Moreover both in human and animal models, evidence of a role of the endometrium as a biosensor of the embryo is emerging.

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Section: Endometrial Uterine Receptivity: Vascular Remodeling and Thementioning

confidence: 99%

New pre-conception immune biomarkers for clinical practice: interleukin-18, interleukin-15 and TWEAK on the endometrial side, G-CSF on the follicular side

Lédée

Petitbarat

Rahmati

et al. 2011

Journal of Reproductive Immunology

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“…Defects in the integrity of cytokine network and an excess of NK cell activity have been implicated in implantation failure and recurrent miscarriage [38][39][40]. Corticosteroids are a class of steroid hormones that are produced in the adrenal cortex with potent anti-inflammatory and immunosuppressive properties including generation, differentiation and function of immune cells with profound consequences for tolerance and immunity [41,42].…”

Section: Corticosteroidsmentioning

confidence: 99%

Adjuvants Therapies for Women Undergoing IVF: Is There Any Evidence of their Safety and Efficacy? An Updated Mini-Review

Fabozzi¹

2017

OGIJ

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In the last two decades a series of adjuvant therapies have been proposed to improve the success of IVF and most of them are currently prescribed even though the quality of scientific evidence supporting their efficacy in improving live birth rates after IVF is weak. The aim of this paper is to describe some of the therapies mostly used by women undergoing IVF such as dehydroepiandrosterone, testosterone, low-dose aspirin, low-molecular-weight heparin (LMWH), corticosteroids and endometrial scratching, and to assess the current evidence about their safety and efficacy. (Relative Risk (RR) 2.13; 95% CI 1.12-4.08). Similar results were obtained in subgroup analyses including randomized controlled trials and case-control studies (RR 2.57; 95% CI 1.43-4.63) and self-controlled studies (RR 3.95;). However, the effects of DHEA on oocyte retrieval, implantation, and abortion were not significant. The Cochrane review conducted in 2015 showed higher ongoing pregnancy rates or live birth rates following the pre-treatment with DHEA. Nevertheless, no benefit was observed when studies with high risk of bias were excluded [14,15]. Finally, a third meta-analysis analysing the effect of DHEA in women with DOR including a total of nine studies, four RCTs, four retrospective and one prospective concluded that clinical pregnancy rates were increased significantly in DOR patients who were pre-treated with DHEA (OR = 1.47, 95% CI: 1.09-1.99), whereas no differences were observed in the number of oocytes retrieved, the cancellation rate of IVF cycles and them is carriage rate between the cases and controls (WMD= −0.69, 95% CI: −2.18-0.81; OR = 0.74,95% CI: 0.51-1.08; OR = 0.34, 95% CI: 0.10-1.24). However, restricting the analysis to only RCTs, a non-significant difference in the clinical pregnancy rate was observed(OR = 1.08, 95% CI: 0.67-1.73) [15]. Keywords: Conclusive statementAlthough the effect of DHEA on improving ovarian response seems to be promising, there is insufficient evidence to recommend DHEA supplementation at this time. Furthermore, the long-term risk of DHEA administration remain unknown. More RCTs with large sample size are needed to obtain good quality evidence on its safety and efficacy. Testosterone (TT)Testosterone is a downstream molecule in the steroidal pathway from DHEA. It can be administered either trans-dermally or orally. Different RCTs report a beneficial effect of TT pre-treatment [16,17] and the meta-analysis from Bosdou et al. [18] analyzing both trials conducted by Massin et al. [16] and Kim et al. [17] reported that pretreatment with transdermal testosterone was associated with an increase in clinical pregnancy (risk difference (RD): +15%, 95% confidence interval (CI): +3 to +26%) and live birth rates (RD: +11%, 95% CI: +0.3 to +22%) in poor responders undergoing ovarian stimulation for IVF. A second meta-analysis conducted by also reported that testosterone-treated women achieved a significantly higher live birth rate (risk ratio, RR, 1.91, 95% CI 1.01 to 3.63), clinical pregnancy ra...

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“…En outre, l'IL18 produite en excès favorise un déséquilibre pro-Th1 susceptible d'entraîner une activation immunitaire délétère, notamment via les cellules uNK qui se transforment en LAK (lymphokine-activated killer cell), mais égale-ment via les cellules dendritiques et les cellules Th17. Un déséquilibre en faveur d'une dominance Th1/Th17 est délétère pour la grossesse et peut s'accompagner de prééclampsie, d'accouchement prématuré ou d'avortement spontané [27][28][29][30][31].…”

Section: Dernières Avancéesunclassified

“…Des données cliniques récentes confirment l'importance de l'expression des membres de la famille de l'IL1 comme marqueur potentiel de la réceptivité maternelle lors de l'implantation embryonnaire. En effet, chez certaines patientes chez lesquelles des échecs d'implantation ont été observés, on a pu mettre en évidence un défaut dans la boucle IL18/IL15/ uNK et une réaction inadéquate de l'endomètre, qui empêchent les phases d'apposition et d'adhérence de l'embryon [31]. À l'inverse, chez d'autres patientes ayant un historique de fausses couches à répétition, une activation et une cytotoxicité excessives des cellules uNK, ainsi qu'une augmentation d'IL18 aux conséquences abortives, ont été identifiées [54].…”

Section: Dernières Avancéesunclassified

L’implantation embryonnaire

Bourdiec

Akoum

2014

Med Sci (Paris)

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Role of the endometrial tripod interleukin-18, -15, and -12 in inadequate uterine receptivity in patients with a history of repeated in vitro fertilization–embryo transfer failure

Cited by 141 publications

References 27 publications

New pre-conception immune biomarkers for clinical practice: interleukin-18, interleukin-15 and TWEAK on the endometrial side, G-CSF on the follicular side

New pre-conception immune biomarkers for clinical practice: interleukin-18, interleukin-15 and TWEAK on the endometrial side, G-CSF on the follicular side

Adjuvants Therapies for Women Undergoing IVF: Is There Any Evidence of their Safety and Efficacy? An Updated Mini-Review

L’implantation embryonnaire

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