Role of thallium-201 in the diagnosis of solitary bone lesions

Stress fracture at the junction of the middle and distal third of the ulnar diaphysis in a spinner bowler: a case report and a review of the literature

“…Although the three-phase bone scan is widely used and is sensitive, its specificity is poor. Like cases reported by others [5,23], the use of Tl-201 scan in this case differentiated malignant from benign lesions in bone and soft tissue. Benign bone lesion tended toward low or normal level of Tl accumulation.…”

To study the efficacy of thallium-201 as tumor seeking agent and to study its role in therapeutic response

“…Few authors feel the ratios should always be interpreted with reservations as there is a significant overlap in these values between benign and malignant lesions. 6,24 Ratios are more indicative if the tumour has not been treated previously. Most important to note that for a lesion which has been treated and found to be thallium negative, any positive scan subsequently indicates recurrence of malignancy, no matter how low the ratio is.…”

Diagnostic value of Thallium-201 scintigraphy in differentiating malignant bone tumors from benign bone lesions

“…Functional nuclear scans reflect the metabolic activity of tumors and may provide important information regarding the biologic behavior. 201Tl scintigraphy has been used in clinical oncology to estimate the presence and biologic activity of tumors including bone and soft tissue tumors, and the utility of 201Tl scintigraphy has been reported to differentiate malignant tumors from benign lesions in bone and soft tissue [2][3][4][5][6][7][8][9][10][11][12][13]. However, these previous studies were composed of a relatively small number of bone tumors and most of the studies used only visual analysis [2,3,5].…”