To study the efficacy of thallium-201 as tumor seeking agent and to study its role in therapeutic response

Kumar, Ankit; Kumar, Pranjal; Somanna, Sampath; Suhag, Virender

doi:10.1016/j.mjafi.2017.01.001

Cited by 7 publications

(4 citation statements)

References 15 publications

(10 reference statements)

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“…201 Tl scintigraphy has been reported to be useful for systemic malignant tumor screening of mammary gland, thyroid, lung, lymph node, and bone and soft tissue tumors. 17 , 18 Its sensitivity is reported to be 94%. 18 201 Tl scintigraphy is considered to be comparable to FDG-PET when used in combination with whole-body contrast-enhanced CT.…”

Section: Discussionmentioning

confidence: 99%

“… 17 , 18 Its sensitivity is reported to be 94%. 18 201 Tl scintigraphy is considered to be comparable to FDG-PET when used in combination with whole-body contrast-enhanced CT. Therefore, we diagnosed primary CNS angiosarcoma.…”

Section: Discussionmentioning

confidence: 99%

“…It is difficult to distinguish metastatic brain tumors from angiosarcoma in the early stages. Positron emission tomography with 18 fluorodeoxyglucose (FDG-PET) is useful and highly sensitive for systemic screening of metastatic brain tumors, including angiosarcoma. On one hand, FDG-PET should have been performed in this case; however, the Japanese public healthcare system does not allow FDG-PET during hospitalization.…”

Section: Observationsmentioning

confidence: 99%

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Multifocal primary central nervous system angiosarcoma: illustrative case

Hirai¹,

Tao²,

Nishimura

et al. 2023

Journal of Neurosurgery: Case Lessons

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BACKGROUND Angiosarcoma is a malignant mesenchymal tumor derived from vascular endothelial cells in which a primary intracranial origin is extremely rare. Most previous reports of primary central nervous system (CNS) angiosarcoma have been solitary cases. OBSERVATIONS The authors report a case of primary CNS angiosarcoma that caused the development of multiple disseminated cerebral hemorrhagic lesions within a short period of time. This rapid progression of symptoms resulted in the death of the patient. During surgery, several nodules suggestive of a tumor were removed from just below the surface of the brain, mixed into the hematoma. A pathological examination revealed atypical cells mimicking blood vessels in the subarachnoid space that were positive for specific vascular endothelial markers. LESSONS In this case, multifocal angiosarcoma occurred on the brain surface and ventricles, suggesting cerebrospinal fluid dissemination. If multiple cerebral hemorrhages are found on the brain surface, multifocal angiosarcoma should also be considered.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Observationsmentioning

confidence: 99%

See 1 more Smart Citation

Multifocal primary central nervous system angiosarcoma: illustrative case

Hirai¹,

Tao²,

Nishimura

et al. 2023

Journal of Neurosurgery: Case Lessons

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“…On the other hand, Tl has been used for tumor imaging due to its similarity to alkali metals such as cesium ( Nadel, 1993 ; Kumar et al, 2017 ). However, the exact mechanism of Tl specificity to tumor cells remains unclear.…”

Section: Thallium and Cancermentioning

confidence: 99%

Thallium-induced DNA damage, genetic, and epigenetic alterations

et al. 2023

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Thallium (Tl) is a toxic heavy metal responsible for noxious effects in living organisms. As a pollutant, Tl can be found in the environment at high concentrations, especially in industrial areas. Systemic toxicity induced by this toxic metal can affect cell metabolism, including redox alterations, mitochondrial dysfunction, and activation of apoptotic signaling pathways. Recent focus on Tl toxicity has been devoted to the characterization of its effects at the nuclear level, with emphasis on DNA, which, in turn, may be responsible for cytogenetic damage, mutations, and epigenetic changes. In this work, we review and discuss past and recent evidence on the toxic effects of Tl at the systemic level and its effects on DNA. We also address Tl’s role in cancer and its control.

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