Role of Th22 cells in Helicobacter pylori-related gastritis and peptic ulcer diseases

Sanaii, Ahmad; Shirzad, Hedayatollah; Haghighian, Mehrnoosh; Rahimian, Ghorbanali; Soltani, Amin; Shafigh, Mohammadhadi; Tahmasbi, Kamran; Bagheri, Nader

doi:10.1007/s11033-019-05004-1

Cited by 25 publications

(20 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It was shown that the number of Th22 cells is significantly higher in infected patients than in healthy ones. There was also a correlation between Th22 cell count and pyloriHelicobacter pylori density and inflammation grade in patients 24 …”

Section: Th22 In Other Diseasesmentioning

confidence: 86%

Features and roles of T helper 22 cells in immunological diseases and malignancies

et al. 2021

View full text Add to dashboard Cite

T helper 22 (Th22) cell populations are a newly identified subset of CD4+ T cells that primarily mediate biological effects on the epithelial barrier through interleukin (IL)‐22. Although, new studies showed that both Th22 and IL‐22 are closely associated with the pathogenesis of inflammatory, autoimmune and allergic disease as well as malignancies. In this review, we aim to describe the development and characteristics of Th22 cells as well as their roles in the immunopathogenesis of immune‐related disorders and cancer.

show abstract

Section: Th22 In Other Diseasesmentioning

confidence: 86%

Features and roles of T helper 22 cells in immunological diseases and malignancies

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Відповідь організму на Н.pylori залежить від стану імунітету людини, як уродженого, так і адаптивного, кількості рецепторів на поверхні шлунка, що сприяють адгезії мікроорганізму, вірулентності Н.pylori тощо [13]. Більшість авторів визначають, що стан захисних механізмів слід розглядати як фактор, що визначає реалізацію патогенних властивостей H.pylori [14][15][16]. Його патогенність у цьому випадку обмежується активністю місцевого імунітету [17].…”

Section: оглядunclassified

Инфекция Helicobacter pylori и витамин D

Sorokman¹,

Popelyuk²,

Ostapchuk³

2021

View full text Add to dashboard Cite

Інфекція Helicobacter pylori та вітамін D Резюме. В огляді проаналізовано роль вітаміну D в патогенезі Helicobacter pylori-асоційованих захворювань шлунково-кишкового тракту та його вплив на успіх ерадикаційної терапії. Наведені сучасні дані про механізм взаємодії між вітаміном D, Helicobacter pylori та імунною системою.

show abstract

“…Our previous researches have determined the number of Treg, Th1, Th17, and Th22 cells in the stomach mucosa quantity of gastro duodenal diseases by immunohistochemistry [24][25][26][27]. For the histopathological estimate, a biopsy sample was taken of gastric antral mucosa.…”

Section: Immunohistochemistry and Histological Examinationmentioning

confidence: 99%

Relationship Between Mucosal TNF-α Expression and Th1, Th17, Th22 and Treg Responses in Helicobacter Pylori Infection

Rahimian

Abadi

Ahmadi

et al. 2021

Preprint

Self Cite

View full text Add to dashboard Cite

Background: Helicobacter pylori (H. pylori) -induced gastric inflammation in the gastric mucosa and significantly increases the risk of developing gastritis and peptic ulcer disease (PUD). The objective of this research is to determine the role of tumor necrosis factor-α (TNF-α) expression in the gastric mucosa of patients with H. pylori –associated gastritis and PUD compared to uninfected patients, and we determined the relation between TNF-α expression and Th1/Th17/Th22, and Treg cells.Methods: Fifty-five patients with H. pylori –associated gastritis, 47 patients with H. pylori –associated PUD, and 48 uninfected patients were in this research. Antrum biopsy was used to detect H. pylori, virulence factors and histopathological assessments.Results: Expression of TNF-α in the infected group was significantly higher than the uninfected group. Also, cagA/oipA-positive infected patients induce significantly more TNF-α expression than do cagA/oipA-negative infected patients. Expression of TNF-α was significantly increased in the PUD group than the gastritis group. Notably, TNF-α expression had a significant positive correlation with the frequency of Th1/Th17/Th22 lymphocytes in the PUD group.Conclusion: These findings indicate the importance of increasing TNF-α with Th1, Th17, Th22 responses increase as an important risk factor for PUD in context of H. pylori infection.

show abstract

Role of Th22 cells in Helicobacter pylori-related gastritis and peptic ulcer diseases

Cited by 25 publications

References 33 publications

Features and roles of T helper 22 cells in immunological diseases and malignancies

Features and roles of T helper 22 cells in immunological diseases and malignancies

Инфекция Helicobacter pylori и витамин D

Relationship Between Mucosal TNF-α Expression and Th1, Th17, Th22 and Treg Responses in Helicobacter Pylori Infection

Contact Info

Product

Resources

About