Features and roles of T helper 22 cells in immunological diseases and malignancies

Zian, Zeineb; Bakkach, Joaira; Kamali, Alí N.; Hosseinzadeh, Reza; Anka, Abubakar Umar; Yazdani, Reza; Azizi, Gholamreza

doi:10.1111/sji.13030

Cited by 17 publications

(18 citation statements)

References 106 publications

(293 reference statements)

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“…It has been found that the differentiation of Th22 is mainly mediated by the transcription factor aromatic hydrocarbon receptor (AHR). 41,42 Th22 cells can secrete IL-22, IL-13, IL-26, and TNF-α, but not IL-17, IFN-γ, or IL-4 (Figure 2). 42 Th1 cells are involved in the immunomodulatory mechanism of RA.…”

Section: Ra Pathogenesismentioning

confidence: 99%

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Immunomodulatory role of T helper cells in rheumatoid arthritis

Luo

Wang

et al. 2022

Bone & Joint Research

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Rheumatoid arthritis (RA) is an autoimmune disease that involves T and B cells and their reciprocal immune interactions with proinflammatory cytokines. T cells, an essential part of the immune system, play an important role in RA. T helper 1 (Th1) cells induce interferon-γ (IFN-γ), tumour necrosis factor-α (TNF-α), and interleukin (IL)-2, which are proinflammatory cytokines, leading to cartilage destruction and bone erosion. Th2 cells primarily secrete IL-4, IL-5, and IL-13, which exert anti-inflammatory and anti-osteoclastogenic effects in inflammatory arthritis models. IL-22 secreted by Th17 cells promotes the proliferation of synovial fibroblasts through induction of the chemokine C-C chemokine ligand 2 (CCL2). T follicular helper (Tfh) cells produce IL-21, which is key for B cell stimulation by the C-X-C chemokine receptor 5 (CXCR5) and coexpression with programmed cell death-1 (PD-1) and/or inducible T cell costimulator (ICOS). PD-1 inhibits T cell proliferation and cytokine production. In addition, there are many immunomodulatory agents that promote or inhibit the immunomodulatory role of T helper cells in RA to alleviate disease progression. These findings help to elucidate the aetiology and treatment of RA and point us toward the next steps. Cite this article: Bone Joint Res 2022;11(7):426–438.

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Section: Ra Pathogenesismentioning

confidence: 99%

“…41,42 Th22 cells can secrete IL-22, IL-13, IL-26, and TNF-α, but not IL-17, IFN-γ, or IL-4 (Figure 2). 42 Th1 cells are involved in the immunomodulatory mechanism of RA. The involvement of Th1 cells in immune regulation in the pathogenesis of RA has been the focus of research since Th1 cells were first identified.…”

Section: Ra Pathogenesismentioning

confidence: 99%

Immunomodulatory role of T helper cells in rheumatoid arthritis

Luo

Wang

et al. 2022

Bone & Joint Research

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“…Studies have revealed that Th22 cells play a regulatory role in the pathogenesis of varied immune disorders, infections, and tumors ( 14 , 15 , 21 , 22 , 142 , 143 ). Here, we provided a brief summary of published research pertaining to the roles of Th22 cells in skin diseases.…”

Section: The Roles Of Th22 Cells In Skin Diseasesmentioning

confidence: 99%

“…Th22 cells have been proposed to play essential roles in autoimmune diseases including rheumatoid arthritis, inflammatory bowel diseases, asthma, multiple sclerosis, immune thrombocytopenia, nephropathy, hepatitis, thyroid diseases, and myasthenia gravis, as well as infectious diseases and tumors (14)(15)(16)(17)(18)(19)(20)(21)(22). Recently, emerging advances regarding the understanding of Th22 cells are allowing in-depth comprehension of the cutaneous immune system, which might promote the development of treatments targeting Th22 cells.…”

Section: Introductionmentioning

confidence: 99%

The Role of T Helper 22 Cells in Dermatological Disorders

Pan

Wang

et al. 2022

Front. Immunol.

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T helper 22 (Th22) cells are a newly identified subset of CD4+ T cells that secrete the effector cytokine interleukin 22 (IL-22) upon specific antigen stimulation, barely with IFN-γ or IL-17. Increasing studies have demonstrated that Th22 cells and IL-22 play essential roles in skin barrier defense and skin disease pathogenesis since the IL-22 receptor is widely expressed in the skin, especially in keratinocytes. Herein, we reviewed the characterization, differentiation, and biological activities of Th22 cells and elucidated their roles in skin health and disease. We mainly focused on the intricate crosstalk between Th22 cells and keratinocytes and provided potential therapeutic strategies targeting the Th22/IL-22 signaling pathway.

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“…9 These cells produce a large number of inflammatory cytokines such as interleukin 1 beta (IL-1β), interferon gamma (IFN-γ), interleukin-17 (IL-17A), IL-17F, interleukin 23 (IL-23) and interleukin 22 (IL-22). [10][11][12] Recently, it has been shown that besides T CD4 cells, T CD8 cells and B cells and macrophages play a major role in the pathogenesis of MS. 13 Moreover, the function of the regulatory T cell subsets (CD4+CD25+ Treg) which produce antiinflammatory cytokines like interleukin 10 (IL-10) and transforming growth factor beta (TGF-β) is impaired. It has also been indicated that T reg cells migration, survival and cytokine production decreased during the MS inflammatory responses.…”

Section: Inflammatory Responses In the Pathogenesis Of Msmentioning

confidence: 99%

The Role of Low-Level Laser Therapy in the Treatment of Multiple Sclerosis: A Review Study

2021

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Introduction: Multiple sclerosis (MS) is an autoimmune disease. Inflammatory cells, cytokines and chemokines play a major role in the pathogenesis of the disease. Low-level laser therapy (LLLT) as a photobiostimulation approach could affect a wide range of cellular responses. LLLT inhibits the inflammatory signaling pathway, improves cell viability, inhibits apoptosis, modulates immune responses and induces the production of growth factors. Methods: In this review, we discuss the effect of LLLT on cellular responses and its application in the treatment of MS. Such keywords as "low-level laser therapy", "photobiomodulation" and "multiple sclerosis" were used to find studies related to laser therapy in MS in Google scholar, PubMed and Medline databases. Results: LLLT reduced the inflammatory immune cells and mediators. It also enhanced the regeneration of neurons. Conclusion: Investigations showed that besides current treatment strategies, LLLT could be a promising therapeutic approach for the treatment of MS.

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Features and roles of T helper 22 cells in immunological diseases and malignancies

Cited by 17 publications

References 106 publications

Immunomodulatory role of T helper cells in rheumatoid arthritis

Immunomodulatory role of T helper cells in rheumatoid arthritis

The Role of T Helper 22 Cells in Dermatological Disorders

The Role of Low-Level Laser Therapy in the Treatment of Multiple Sclerosis: A Review Study

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