Role of Th22 and IL-22 in pathogenesis of allergic airway diseases: Pro-inflammatory or anti-inflammatory effect?

Tamašauskienė, Laura; Šitkauskienė, Brigita

doi:10.1016/j.pedneo.2017.11.020

Cited by 17 publications

(20 citation statements)

References 41 publications

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“…However, the role of IL-22 in the allergic airway diseases is still controversial (pro-inflammatory effects vs. anti-inflammatory properties). 28 In this study, we showed that, in patients with CRSwNP, IL-22 expression was positively correlated with type 2 inflammatory cytokines. In addition to eosinophils, mast cells might be the potential source of IL-22 in NP tissues responding to subsequent IgE-mediated signals.…”

Section: Discussionmentioning

confidence: 60%

Enhanced Type 2 Immune Reactions by Increased IL-22/IL-22Ra1 Signaling in Chronic Rhinosinusitis With Nasal Polyps

Kim

Lim

et al. 2020

Allergy Asthma Immunol Res

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Purpose Recent studies have revealed the pathogenic role of interleukin (IL)-22 in atopic dermatitis and asthma. However, little is known about the role of IL-22 in the pathophysiology of chronic rhinosinusitis with nasal polyps. We aimed to investigate the expression of IL-22 and its pathogenic function in type 2 immune reactions of nasal polyps (NP). Methods Protein levels of inflammatory mediators were determined by multiplex immunoassay, and principal component analysis (PCA) was performed. Immunofluorescence analysis and mast cell culture were used to determine the cellular sources of IL-22. Normal human bronchial epithelial (NHBE) cells were stimulated using IL-22 in combination with diverse cytokines, and thymic stromal lymphopoietin (TSLP) was measured. Results IL-22 expression was not up-regulated in NP compared with control tissues, but IL-22-high NP revealed distinct features characterized by type 2 inflammatory cytokines such as chemokine (C-C motif) ligand (CCL)-11, CCL-24, and IL-5 on the PCA. Additionally, IL-22 positively correlated with type 2 immune mediators and the disease severity in NP. For the localization of the cellular sources of IL-22 in eosinophilic NP, it was expressed in cells mostly composed of eosinophil peroxidase-positive cells and partially of tryptase-positive cells. The human mast cell line, LAD2 cells, released IL-22 mediated by immunoglobulin E. Moreover, IL-22 receptor subunit alpha-1 (IL-22Ra1) expression was significantly increased in NP. IL-22Ra1 was up-regulated with poly(I:C) stimulation in NHBE cells. Furthermore, TSLP production was enhanced when stimulated with a combination of IL-13, poly(I:C), and IL-22. Treatment with anti-IL-22Ra1 also inhibited IL-22-induced enhancement of TSLP production. Conclusion IL-22 was associated with type 2 inflammatory reactions in NP. The IL-22/IL-22Ra1 axis was enhanced and might be involved in type 2 inflammatory reactions via TSLP production in NP.

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Section: Discussionmentioning

confidence: 60%

Enhanced Type 2 Immune Reactions by Increased IL-22/IL-22Ra1 Signaling in Chronic Rhinosinusitis With Nasal Polyps

Kim

Lim

et al. 2020

Allergy Asthma Immunol Res

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“…It has been recognized that the interleukin (IL) family members are involved in the etiologies of various inflammation-related conditions, such as infectious diseases [4][5][6], immunological disorders [7][8][9][10] and neoplasms [10]. In a comprehensive review article that depicted IL-6 profiles in patients receiving different cardiac operations.…”

Section: Introductionmentioning

confidence: 99%

Interleukin-13 in the pathogenesis of pulmonary artery hypertension

Yuan

2019

Journal of Laboratory Medicine

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Background Interleukin (IL)-13 is a regulatory factor of tissue remodeling and is involved in the pathogenesis of pulmonary artery hypertension (PAH). However, the implications of IL-13 in PAH remains uncertain. This article aims to describe the current knowledge on production and function of IL-13 and its receptors in the mechanisms of PAH. Content The study materials of this article were based on comprehensive literature retrieval of publications of IL-13 in PAH. These study materials were carefully reviewed, analyzed and discussed. Summary IL-13 levels in blood and lung tissue were elevated in both animal models of PAH and patients with PAH in comparison to non-PAH controls. Types I and II IL-13 receptors participate in pulmonary artery remodeling through signal transducer and activator of transcription (STAT)6 or through phosphatidylinositol 3-kinase (PI3K), STAT3 and mitogen activated protein kinase (MAPK) pathways. Oxidant, arginase 2 (Arg2) and hypoxia-inducible factor 1α are involved in the proliferation of pulmonary artery smooth muscle cells. Outlook Types I and II IL-13 receptors play an important role in the IL-13 signaling by STAT6 via Janus kinase kinases, and by PI3K, STAT3 and MAPK pathways, respectively. Alternative pathways, including oxidant, Arg2 and hypoxia-inducible factor 1α might be also involved in the pathological process of PAH development. Investigational therapies by inflammatory suppression or thrombolytic and anticoagulant agents could inhibit intimal hyperplasia of the pulmonary arteries and suppress pulmonary vasculature remodeling. Drug research and development oriented by this hypothesis would confer benefits to the treatment of PAH.

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“…Our ndings support hypothesis of antiin ammatory effect of IL-22 in persistent allergic airway diseases. However, experimental, and clinical studies provide controversial data about possible role of IL-22 in these diseases (14,21).…”

Section: Discussionmentioning

confidence: 99%

“…It is thought that type 1 and type 3 immunity is important in the development of autoimmune disorders or chronic non-allergic airway in ammation (11,12). However, there are evidences that IL-22 can also be involved in allergic airway in ammation (13)(14)(15)(16).…”

Section: Introductionmentioning

confidence: 99%

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Role of IL-22 in Persistent Allergic Airway Diseases Caused by House Dust Mite: A Pilot Study

Tamašauskienė

Gintauskienė

Bastyte

et al. 2020

Preprint

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Background. Persistent allergic airway diseases cause a great burden worldwide. Their pathogenesis is not clear enough. There is evidence that one of the recently described cytokine interleukin (IL) 22 may be involved in the pathogenesis of these diseases. Scientists argue if this cytokine acts as proinflammatory or anti-inflammatory agent. The aim of this study was to investigate IL-22 level in patients with persistent allergic airway diseases caused by house dust mite (HDM) in comparison with healthy individuals and to evaluate its relationship with IL-13 and IL-10 level, symptoms score and quality of life.Methods. Patients with persistent allergic rhinitis caused by HDM and having symptoms for at least 2 years with or without allergic asthma were involved into the study. Measurements of IL-22, IL-13 and IL-10 and in serum and nasal lavage was performed by ELISA. Questionnaires assessing symptoms severity and quality of life were used.Results. A tendency was observed that IL-22 in serum and nasal lavage was higher in patients with allergic airway diseases compared to control group (14.86 pg/ml vs. 7.04 pg/ml and 2.67 pg/ml vs. 1.28 pg/ml, respectively). Positive statistically significant correlation was estimated between serum IL-22 and serum IL-10 (rs=0.57, p<0.01) and IL-13 (rs=0.44, p<0.05) level. Moreover, positive significant correlation was found between IL-22 in nasal lavage and IL-10 in nasal lavage (rs=0.37, p<0.05). There was a negative statistically significant correlation between serum IL-22 and RQLQ (rs=-0.42, p<0.05).Conclusion. Our study showed a possible anti-inflammatory effect of IL-22 in patients with persistent allergic airway diseases caused by HDM.

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Role of Th22 and IL-22 in pathogenesis of allergic airway diseases: Pro-inflammatory or anti-inflammatory effect?

Cited by 17 publications

References 41 publications

Enhanced Type 2 Immune Reactions by Increased IL-22/IL-22Ra1 Signaling in Chronic Rhinosinusitis With Nasal Polyps

Enhanced Type 2 Immune Reactions by Increased IL-22/IL-22Ra1 Signaling in Chronic Rhinosinusitis With Nasal Polyps

Interleukin-13 in the pathogenesis of pulmonary artery hypertension

Role of IL-22 in Persistent Allergic Airway Diseases Caused by House Dust Mite: A Pilot Study

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