Role of surgery in the management of anaplastic thyroid carcinoma: Korean nationwide multicenter study of 329 patients with anaplastic thyroid carcinoma, 2000 to 2012

Baek, Seung Kuk; Lee, Myung Chul; Hah, J. Hun; Ahn, Sang‐Hyeon; Son, Young Ik; Rho, Young Soo; Chung, Phil‐Sang; Lee, Yoon Se; Koo, Bon Seok; Jung, Kwang‐Yoon; Lee, Byung‐Joo

doi:10.1002/hed.24559

Cited by 36 publications

(44 citation statements)

References 22 publications

(29 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In this study, surgery with curative intent -therefore excluding debulking procedures -was associated with better survival in stage IVA and IVB but not in IVC patients (Baek et al 2016). Another recent study from Korea shows surgical intervention for selected patients might indeed result in a prolonged survival benefit.…”

Section: Surgerymentioning

confidence: 44%

Anaplastic thyroid carcinoma: review of treatment protocols

Tiedje¹,

Stuschke²,

Weber³

et al. 2018

Endocrine-Related Cancer

View full text Add to dashboard Cite

Anaplastic thyroid carcinoma (ATC) is an orphan disease and in most patients fatal. So far no established treatment is available that prolongs survival. Several large retrospective studies have identified negative prognostic markers, analyzed efficacy of multimodal approaches such as radiotherapy with and without concurrent chemotherapy and chemotherapy protocols. Recently, single case reports have suggested some effectiveness of newer therapies targeting single somatic alterations in ATC. Overall, the conclusions that can be drawn from published retrospective studies and the scarce prospective approaches is that new treatment protocols should be developed including surgery, radiotherapy, chemotherapy and targeted therapy approaches and combinational therapy with immunotherapies. These protocols then need to be evaluated prospectively to improve ATC patients' outcome in routine care.

show abstract

Section: Surgerymentioning

confidence: 44%

Anaplastic thyroid carcinoma: review of treatment protocols

Tiedje¹,

Stuschke²,

Weber³

et al. 2018

Endocrine-Related Cancer

View full text Add to dashboard Cite

show abstract

“…Further regarding metastatic diseases, from our literature revision emerged only retrospective data of 779 patients [ 10 , 11 , 12 , 22 , 23 , 24 , 29 , 30 , 31 , 32 , 33 , 51 , 52 , 53 ], treated with a multimodality approach ( Table 1 ) and with a median overall survival that ranges from 3 to 28 months.…”

Section: Resultsmentioning

confidence: 99%

“…Evaluating the survival outcomes according to the different clinical features and treatments, they identified age ≥70 years old, the presence of initial clinical symptoms, distant metastasis and treatment modality as significant risk factors ( p < 0.05). Overall, the patients who underwent curative surgery and adjuvant radiotherapy or concurrent chemoradiation obtained the best survival ( p < 0.05) [ 33 ].…”

Section: Resultsmentioning

confidence: 99%

Uncommon Site of Metastasis and Prolonged Survival in Patients with Anaplastic Thyroid Carcinoma: A Systematic Review of the Literature

Mirabile

Biafora

Giordano

et al. 2020

Cancers

View full text Add to dashboard Cite

Anaplastic thyroid carcinoma (ATC) is a very rare, highly aggressive malignant thyroid tumor with an overall survival from 3 to 5 months in most of the cases. Even the modern and intensive treatments seem not to be enough to provide a cure, also for the resectable ones, and the role of chemotherapy is still unclear but does not seem to prolong survival. Nevertheless, some patients survive longer and have a better outcome, even in the presence of metastasis, than what the literature reports. We present the case of a 64-year-old female affected by ATC, treated on February 2018 with surgery followed by chemoradiation. One year after surgery, the patient developed a subcutaneous recurrence that was radically resected and is still alive 29 months after the diagnosis. We propose a systematic review of the literature to deepen the knowledge of the prognostic factors of ATC with the aim to recognize and select the patients with a better outcome, even if metastatic, and to describe a very uncommon site of metastatization.

show abstract

“…Radiotherapy. Optimal outcomes in terms of survival and local disease control in ATC require complete or near-complete [no residual tumour (R0) or microscopic residual tumour (R1)] resection followed by high-dose EBRT, with or without concomitant ChT [V, A] [122,123]. However, this multimodal approach can strongly impact QoL and should be reserved for carefully selected patients to ensure clinical benefit.…”

Section: Management Of Local/locoregional Diseasementioning

confidence: 99%

Thyroid cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

et al. 2019

View full text Add to dashboard Cite

Role of surgery in the management of anaplastic thyroid carcinoma: Korean nationwide multicenter study of 329 patients with anaplastic thyroid carcinoma, 2000 to 2012

Abstract: Although ATC is a lethal neoplasm, long-term survival may be acquired in cases in which the aggressive management, including curative resection or RT/concurrent CRT, is possible for therapeutic intent. © 2016 Wiley Periodicals, Inc. Head Neck 39: 133-139, 2017.

Cited by 36 publications

References 22 publications

Anaplastic thyroid carcinoma: review of treatment protocols

Anaplastic thyroid carcinoma: review of treatment protocols

Uncommon Site of Metastasis and Prolonged Survival in Patients with Anaplastic Thyroid Carcinoma: A Systematic Review of the Literature

Thyroid cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

Contact Info

Product

Resources

About