Role of sulphated polysaccharides from Sargassum Wightii in Cyclosporine A-induced oxidative liver injury in rats

Josephine, Anthony; Nithya, K.; Amudha, Ganapathy; Veena, Coothan Kandaswamy; Preetha, S.; Varalakshmi, P.

doi:10.1186/1471-2210-8-4

Cited by 54 publications

(36 citation statements)

References 44 publications

(38 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…K. alvarezii extracts exhibit significant protective effects against DNA damage induced by H 2 O 2 , which might be related to antioxidant activity. Similar reports were previously reported in Sargassum wightii (Josephine et al 2008), Ulva rigida and Fucus vesiculosus (Cleide et al 2007;Celikler et al 2008).…”

Section: Discussionsupporting

confidence: 79%

Investigation of the effect ofK. alvareziion antioxidant enzymes, cell viability and DNA damage in male rats

Nagarani

Kumaraguru

2012

Frontiers in Life Science

View full text Add to dashboard Cite

In recent years, a significant number of novel metabolites with potent pharmacological properties (antioxidant, antitumor, anti-HIV) have been discovered from marine organisms. Kappaphycus alvarezii (Doty) is a marine alga belonging to order: Gigartinales and family: Solieriaceae. It has been invasive in the Gulf of Mannar since 2000, and has a high content of the steroid phenol. This is the first report on its antioxidant properties using an animal model. This study aimed to explore the antioxidant and antigenotoxic/protective role of K. alvarezii growing in southeast coast of India in the male rat. The findings indicate that an extract of K. alvarezii is not nephrotoxic at the dose levels. The algal antioxidant activity shows similar correlation (89%; R 2 = 0.8963) at varying temperature to the known antioxidant. K. alvarezii extracts exhibit significant protective effects against DNA damage induced by H 2 O 2 , which might be related to antioxidant activity. In conclusion, our results suggest that long-term daily administration of K. alvarezii extract offers enhanced antioxidant potential and protection against tissue lipid peroxidation and cell damage. Our results support the use of K. alvarezii in the food and pharmaceutical industries.

show abstract

Section: Discussionsupporting

confidence: 79%

Investigation of the effect ofK. alvareziion antioxidant enzymes, cell viability and DNA damage in male rats

Nagarani

Kumaraguru

2012

Frontiers in Life Science

View full text Add to dashboard Cite

show abstract

“…The positive effects of APS with effective antioxidant properties are possibly due to solving problems associated with intestinal impairment and protein proteolysis from high ambient temperature. Previously, Josephine et al (2008) observed that oxidative stress could inhibit Na + K + -ATPase, Ca 2+ -ATPase, and Mg 2+ -ATPase activities and induce the cellular membrane damage. However, sulphated polysaccharides could restore the activities of these ATPases and show its beneficial effect in maintaining the membrane integrity.…”

Section: Tablementioning

confidence: 99%

Alfalfa polysaccharides improve the growth performance and antioxidant status of heat-stressed rabbits

et al. 2010

View full text Add to dashboard Cite

“…Sargassum is tropical and sub-tropical brown algae comprising 150 species, common to all oceans except Antarctica (Dar et al, 2007). Sargassum have been studied extensively, and polysaccharides extracted from different Sargassum algae such as S. dentifolium (Amira et al, 2013), S. wightii (Josephine et al, 2008), S. thunbergii and others (Kang et al, 2008) were reviewed and showed the diverse bioactivities such as anti-oxidant, antiinflammatory, anti-genotoxic, and anti-cancer. However, the mechanisms underlying the anti-inflammatory properties of the ethanol extract of Sargauum fulvellum (S. fulvellum) are yet to be established.…”

Section: Introductionmentioning

confidence: 99%

Inhibitory Effect of Sargauum fulvellum Ethanolic Extract on LPS-Induced Inflammatory Reaction in RAW 264.7 Mouse Macrophages

Kim¹,

Kim²,

Jeong³

et al. 2013

Journal of Applied Biological Chemistry

View full text Add to dashboard Cite

Recently, algae has been considered as a potential antiinflammatory source due to its distinctive habitat environment exposing to light and high oxygen concentration. In present study, anti-inflammatory effect of brown alga, Sargassum fullvellum ethanol extract (SFEE), was examined. SFEE inhibited not only the production of nitric oxide and pro-inflammatory cytokines (IL-6, IL-1β, TNF-α) but also the expression of inducible nitric oxide synthase and cyclooxygenase 2 in LPS-induced RAW 264.7 cells without affecting cell viability. SFEE also suppressed the expression of nuclear factor kappa B (NF-κB), suggesting that SFEE could affect the expression of inflammation related cytokines and proteins through the regulation of NF-κB. Furthermore, formation of edema of the ear was 40% lower in mice treated with the highest dose (250 mg/kg) of SFEE than in the control mice. Thus, our study showed that SFEE may be a potential therapeutic anti-inflammatory drug.

show abstract

Role of sulphated polysaccharides from Sargassum Wightii in Cyclosporine A-induced oxidative liver injury in rats

Cited by 54 publications

References 44 publications

Investigation of the effect ofK. alvareziion antioxidant enzymes, cell viability and DNA damage in male rats

Investigation of the effect ofK. alvareziion antioxidant enzymes, cell viability and DNA damage in male rats

Alfalfa polysaccharides improve the growth performance and antioxidant status of heat-stressed rabbits

Inhibitory Effect of Sargauum fulvellum Ethanolic Extract on LPS-Induced Inflammatory Reaction in RAW 264.7 Mouse Macrophages

Contact Info

Product

Resources

About