Inhibitory Effect of Sargauum fulvellum Ethanolic Extract on LPS-Induced Inflammatory Reaction in RAW 264.7 Mouse Macrophages

Kim, Min Ji; Kim, Koth Bong Woo Ri; Jeong, Da Hyun; Ahn, Dong Hyun

doi:10.3839/jabc.2013.040

Cited by 8 publications

(5 citation statements)

References 31 publications

(26 reference statements)

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“…These facts indicated that the relatively lipophilic compounds tended to be responsible for the anti-inflammatory activity. This was supported by several other studies showing a similar tendency that a relatively lipophylic extract or fraction has a promising anti-inflammatory effect [19,20,21,22,23,24,25,26,27,28,29,30,31,32,33].…”

Section: Sargassum Species Are a Source Of Anti-inflammatory Agentssupporting

confidence: 75%

Sargassum Seaweed as a Source of Anti-Inflammatory Substances and the Potential Insight of the Tropical Species: A Review

et al. 2019

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Sargassum is recognized both empirically and scientifically as a potential anti-inflammatory agent. Inflammation is an important response in the body that helps to overcome various challenges to body homeostasis such as microbial infections, tissue stress, and certain injuries. Excessive and uncontrolled inflammatory conditions can affect the pathogenesis of various diseases. This review aims to explore the potential of Sargassum's anti-inflammatory activity, not only in crude extracts but also in sulfated polysaccharides and purified compounds. The tropical region has a promising availability of Sargassum biomass because its climate allows for the optimal growth of seaweed throughout the year. This is important for its commercial utilization as functional ingredients for both food and non-food applications. To the best of our knowledge, studies related to Sargassum's anti-inflammatory activity are still dominated by subtropical species. Studies on tropical Sargassum are mainly focused on the polysaccharides group, though there are some other potentially bioactive compounds such as polyphenols, terpenoids, fucoxanthin, fatty acids and their derivatives, typical polar lipids, and other groups. Information on the modulation mechanism of Sargassum's bioactive compounds on the inflammatory response is also discussed here, but specific mechanisms related to the interaction between bioactive compounds and targets in cells still need to be further studied.

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Section: Sargassum Species Are a Source Of Anti-inflammatory Agentssupporting

confidence: 75%

Sargassum Seaweed as a Source of Anti-Inflammatory Substances and the Potential Insight of the Tropical Species: A Review

et al. 2019

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“…The reason for the decrease in NO secretion could be the monosaccharide formation by the breakdown of alginic acid polysaccharides (Figure 1). These results showed that the NO inhibition activity of SFEE using crude enzyme from S. oneidensis PKA 1008 was higher than treatment with the S. fulvellum ethanolic extract at 100 µg/mL (Kim et al, 2013). In addition, in a study investigating the inhibitory effect of U. pinnatifida root (UPT) enzymatic extract on NO production in LPS-induced RAW 264.7 cells, the secretion of NO by LPS stimulation was significantly inhibited by UPT enzymatic extract treatment (Xu et al, 2020).…”

Section: Effect On Lps-induced Nitric Oxidementioning

confidence: 93%

Characteristics and anti-inflammatory effects of the enzymatically extracted polysaccharides of Sargassum fulvellum using crude enzyme from Shewanella oneidensis PKA 1008

Xu¹,

Jeong²,

Lee³

et al. 2022

IFRJ

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Alginic acid is a polysaccharide obtained from brown algae, and its oligosaccharide has various functions such as antiviral, antitumor, immunoregulation, and antioxidant. However, because of its high viscosity, numerous studies have degraded the alginic acid by enzymes to improve its utilisation. In the present work, we characterised Sargassum fulvellum enzymatic extract (SFEE) using polysaccharide-degrading enzyme obtained from Shewanella oneidensis PKA 1008, and investigated its anti-inflammatory potential. S. fulvellum powder and crude enzyme were mixed at a ratio of 1:1 (v/v), and reacted at 30°C for 0 - 48 h to obtain the optimum degrading time. The changes in pH, colour, reducing sugar, and viscosity of SFEE were determined. The anti-inflammatory activity of SFEE was confirmed by measuring the expression level of nitric oxide (NO) and pro-inflammatory cytokines (IL-6, TNF-α, and L-1β) in RAW 264.7 macrophage cell line. The reducing sugar content was found to increase 2.75-fold at 24 h as compared to that at the initial reaction point, but pH and viscosity decreased significantly with increasing reaction time. SFEE showed a high inhibitory effect on the levels of NO and pro-inflammatory cytokines. SFEE thus has great potential for development as a functional food and therapeutic material owing to its anti-inflammatory effect.

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“…SFEE also suppressed the expression of NF- κ B, suggesting that SFEE could affect the expression of inflammation-related cytokines and proteins through the regulation of NF- κ B. Furthermore, the formation of ear edema was 40% lower in mice treated with the highest dose (250 mg/kg) of SFEE than that in the control mice [ 57 ].…”

Section: Biological Activities Of S Fulvellummentioning

confidence: 99%

Pharmaceutical and Nutraceutical Potential Applications of Sargassum fulvellum

Liu

Luthuli

et al. 2020

BioMed Research International

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Sargassum fulvellum is a brown seaweed of the Sargassaceae family which has been demonstrated to exhibit antipyretic, analgesic, antiedema, antimicrobial, antioxidant, antitumor, neuroprotective, anticoagulative, anti-inflammatory, and hepatoprotective activities. It has been widely used as a food additive and as a medicine in oriental medicine to treat lumps, dropsy, swelling, testicular pains, and urinary problems. S. fulvellum has been identified as a potential producer of a wide spectrum of natural compounds such as carotenoids, fucoidans, and phlorotannins, showing different biological activities in various industrial applications including pharmaceutical, nutraceutical, cosmeceutical, and functional food. However, the promising health effects associated with the extracts and compounds isolated from S. fulvellum have not been reviewed to date. The present review thus focuses on the biological activity of S. fulvellum as reported by previous publications, which include antioxidant, anticoagulant, anti-inflammatory, neuroprotective, immunomodulatory, antidiabetic, and anticancer effects. Thus, this review might serve to increase the utilization of this invaluable natural source as a potential component in pharmaceutical and nutraceutical applications.

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Inhibitory Effect of Sargauum fulvellum Ethanolic Extract on LPS-Induced Inflammatory Reaction in RAW 264.7 Mouse Macrophages

Cited by 8 publications

References 31 publications

Sargassum Seaweed as a Source of Anti-Inflammatory Substances and the Potential Insight of the Tropical Species: A Review

Sargassum Seaweed as a Source of Anti-Inflammatory Substances and the Potential Insight of the Tropical Species: A Review

Characteristics and anti-inflammatory effects of the enzymatically extracted polysaccharides of Sargassum fulvellum using crude enzyme from Shewanella oneidensis PKA 1008

Pharmaceutical and Nutraceutical Potential Applications of Sargassum fulvellum

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