Role of Streptococcus pneumoniae Proteins in Evasion of Complement-Mediated Immunity

André, Greiciely O.; Converso, Thiago Rojas; Politano, Walter Rodrigo; Ferraz, Lúcio Fábio Caldas; Ribeiro, Marcelo Lima; Leite, Luciana C. C.; Darrieux, Michelle

doi:10.3389/fmicb.2017.00224

Cited by 69 publications

(65 citation statements)

References 206 publications

(308 reference statements)

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“…Many of the virulence determinants of S. pneumoniae target components of the complement system to minimize and clearance of invading pneumococci (reviewed in Ref. 134 ). The CPS is undoubtedly the most important defence against the host immune system.…”

Section: Invasive Pneumococcal Diseasementioning

confidence: 99%

“…Factor H mainly binds CbpA on the pneumococcal surface. CbpA can also bind directly to C3 and, in some strains, the classical complement pathway inhibitor C4b-b inding protein (C4BP) in an interaction that is inhibited by CbpA binding to vitronectin 134,138,139 . Thus, CPS and CbpA on the pneumococcal surface are both important for resistance to opsonophagocytosis.…”

Section: Invasive Pneumococcal Diseasementioning

confidence: 99%

“…Other pneumococcal proteins that interfere with opsonophagocytosis include the exoglycosidases NanA, BgaA and StrH, presumably by deglycosylating human glycoproteins that are important for complement deposition 143 . Eno and glyceraldehyde-3-phosphate dehydrogenase (GAPDH) bind and activate plasminogen, and this can also contribute to immune evasion through the degradation of complement pathway components 134 . S. pneumoniae grows in both short-chain and long-chain forms.…”

Section: Invasive Pneumococcal Diseasementioning

confidence: 99%

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Streptococcus pneumoniae: transmission, colonization and invasion

2018

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Streptococcus pneumoniae as a complex relationship with its obligate human host. On the one hand, the pneumococci are highly adapted commensals, and their main reservoir on the mucosal surface of the upper airways of carriers enables transmission. On the other hand, they can cause severe disease when bacterial and host factors allow them to invade essentially sterile sites, such as the middle ear spaces, lungs, bloodstream and meninges. Transmission, colonization and invasion depend on the remarkable ability of S. pneumoniae to evade or take advantage of the host inflammatory and immune responses. The different stages of pneumococcal carriage and disease have been investigated in detail in animal models and, more recently, in experimental human infection. Furthermore, widespread vaccination and the resulting immune pressure have shed light on pneumococcal population dynamics and pathogenesis. Here, we review the mechanistic insights provided by these studies on the multiple and varied interactions of the pneumococcus and its host.

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Section: Invasive Pneumococcal Diseasementioning

confidence: 99%

Section: Invasive Pneumococcal Diseasementioning

confidence: 99%

Section: Invasive Pneumococcal Diseasementioning

confidence: 99%

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Streptococcus pneumoniae: transmission, colonization and invasion

2018

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“…LytA, also known as autolysin, digests the cell wall and releases pneumolysin and other cellular contents (van der Poll and Opal 2009). Moreover, it inhibits C3 convertase formation (Andre et al 2017). PsaA, pneumococcal surface antigen A, is involved in metal ion uptake, which leads to protection from oxidative stress (Kadioglu et al 2008).…”

Section: S Pneumoniaementioning

confidence: 99%

Pneumonia and Streptococcus pneumoniae vaccine

2017

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Pneumonia is an inflammatory disease of the lung, responsible for high morbidity and mortality worldwide. It is caused by bacteria, viruses, fungi, or other microorganisms. Streptococcus pneumoniae, a gram-positive bacterium with over 90 serotypes, is the most common causative agent. Moreover, comorbid factors including heart failure, renal disease, and pulmonary disease could increase the risk of pneumococcal pneumonia. Since the advent of the pneumococcal vaccine in the 1980s, the incidence of pneumonia has decreased significantly. However, current vaccines confer only limited protection against serotypes included in the vaccine. Thus, to overcome this limitation, new types of pneumococcal vaccines have been sought and under clinical trials. In this review, we discuss pneumonia and summarize the various types of pneumococcal vaccines in progress.

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“…These proteins can act as adhesins and are often referred to as microbial surface components recognizing adhesive matrix molecules (MSCRAMMs) of the host. Besides colonization, several MSCRAMMs of S. pneumoniae and S. aureus exert multiple other functions, including immune evasion or immune modulation of the host to facilitate the dissemination of the pathogen [1-4]. …”

Section: Introductionmentioning

confidence: 99%

Contribution of Human Thrombospondin-1 to the Pathogenesis of Gram-Positive Bacteria

Binsker¹,

Kohler²,

Hammerschmidt³

2019

J Innate Immun

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A successful colonization of different compartments of the human host requires multifactorial contacts between bacterial surface proteins and host factors. Extracellular matrix proteins and matricellular proteins such as thrombospondin-1 play a pivotal role as adhesive substrates to ensure a strong interaction with pathobionts like the Gram-positive Streptococcus pneumoniae and Staphylococcus aureus. The human glycoprotein thrombospondin-1 is a component of the extracellular matrix and is highly abundant in the bloodstream during bacteremia. Human platelets secrete thrombospondin-1, which is then acquired by invading pathogens to facilitate colonization and immune evasion. Gram-positive bacteria express a broad spectrum of surface-exposed proteins, some of which also recognize thrombospondin-1. This review highlights the importance of thrombospondin-1 as an adhesion substrate to facilitate colonization, and we summarize the variety of thrombospondin-1-binding proteins of S. pneumoniae and S. aureus.

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Role of Streptococcus pneumoniae Proteins in Evasion of Complement-Mediated Immunity

Cited by 69 publications

References 206 publications

Streptococcus pneumoniae: transmission, colonization and invasion

Streptococcus pneumoniae: transmission, colonization and invasion

Pneumonia and Streptococcus pneumoniae vaccine

Contribution of Human Thrombospondin-1 to the Pathogenesis of Gram-Positive Bacteria

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