Role of Sodium/Calcium Exchangers in Tumors

Chovancova, Barbora; Lišková, Veronika; Babula, Petr; Križanová, Oľga

doi:10.3390/biom10091257

Cited by 33 publications

(21 citation statements)

References 62 publications

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“…Lack of Ca 2+ entry causes defective oxidative metabolism in the liver, heart, skeletal muscle, and adipose tissue [ 50 ]. The electrogenic Na + /Ca 2+ exchanger is related to Na + influx and Ca 2+ release across the plasma membrane [ 51 , 52 ].…”

Section: Ca 2+ Signaling and Mitochondriamentioning

confidence: 99%

Emerging Role of TCA Cycle-Related Enzymes in Human Diseases

Kang

Suzuki

Saitô

et al. 2021

IJMS

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The tricarboxylic acid (TCA) cycle is the main source of cellular energy and participates in many metabolic pathways in cells. Recent reports indicate that dysfunction of TCA cycle-related enzymes causes human diseases, such as neurometabolic disorders and tumors, have attracted increasing interest in their unexplained roles. The diseases which develop as a consequence of loss or dysfunction of TCA cycle-related enzymes are distinct, suggesting that each enzyme has a unique function. This review aims to provide a comprehensive overview of the relationship between each TCA cycle-related enzyme and human diseases. We also discuss their functions in the context of both mitochondrial and extra-mitochondrial (or cytoplasmic) enzymes.

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Section: Ca 2+ Signaling and Mitochondriamentioning

confidence: 99%

Emerging Role of TCA Cycle-Related Enzymes in Human Diseases

Kang

Suzuki

Saitô

et al. 2021

IJMS

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“…Several FDA-approved anticancer agents (such as 5-fluorouracil, cisplatin, tamoxifen, paclitaxel, and doxorubicin) and drugs against other disease conditions (such as leflunomide, tolvaptan, and teriflunomide) can impact Ca 2+ signaling machinery [ 484 , 485 ]. Some of these drugs, formulated as prodrugs or nanocarrier loads, are under investigation as antagonists of cancer-promoting Ca 2+ signaling See Figure 12 [ 46 , 226 , 227 , 252 , 440 , 441 , 486 , 487 , 488 , 489 , 490 , 491 , 492 , 493 , 494 , 495 , 496 , 497 , 498 , 499 , 500 , 501 , 502 , 503 , 504 , 505 , 506 , 507 , 508 , 509 , 510 , 511 , 512 , 513 , 514 , 515 , 516 , 517 , 518 , 519 , 520 , 521 , 522 , 523 , …”

Section: Conclusion and Discussionmentioning

confidence: 99%

Advances in Intracellular Calcium Signaling Reveal Untapped Targets for Cancer Therapy

2021

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Intracellular Ca2+ distribution is a tightly regulated process. Numerous Ca2+ chelating, storage, and transport mechanisms are required to maintain normal cellular physiology. Ca2+-binding proteins, mainly calmodulin and calbindins, sequester free intracellular Ca2+ ions and apportion or transport them to signaling hubs needing the cations. Ca2+ channels, ATP-driven pumps, and exchangers assist the binding proteins in transferring the ions to and from appropriate cellular compartments. Some, such as the endoplasmic reticulum, mitochondria, and lysosomes, act as Ca2+ repositories. Cellular Ca2+ homeostasis is inefficient without the active contribution of these organelles. Moreover, certain key cellular processes also rely on inter-organellar Ca2+ signaling. This review attempts to encapsulate the structure, function, and regulation of major intracellular Ca2+ buffers, sensors, channels, and signaling molecules before highlighting how cancer cells manipulate them to survive and thrive. The spotlight is then shifted to the slow pace of translating such research findings into anticancer therapeutics. We use the PubMed database to highlight current clinical studies that target intracellular Ca2+ signaling. Drug repurposing and improving the delivery of small molecule therapeutics are further discussed as promising strategies for speeding therapeutic development in this area.

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“…Aquaporins (AQP) are water channels that regulate serum sodium concentration with aggressive behavior in breast cancer [ 49 ], liver cancer [ 50 ], esophageal cancer [ 51 ] and gastric cancer [ 52 ]. It is also important to note that the expression and membrane localization of ion exchanger channels, such as the sodium/calcium exchanger (NCX) that enables the bi-directional movement of calcium and sodium ions based on net electrochemical gradient, were increased in leukemia, esophageal cancer, pancreatic cancer and breast cancer [ 53 , 54 ].…”

Section: Salt Induced Tumorigenesismentioning

confidence: 99%

Cancer Salt Nostalgia

Allu

Tiriveedhi

2021

Cells

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High-salt (sodium chloride) diets have been strongly associated with disease states and poor health outcomes. Traditionally, the impact of salt intake is primarily studied in cardiovascular diseases, hypertension and renal diseases; however, recently there has been increasing evidence demonstrating the role of salt in autoimmune diseases. Salt has been shown to modulate the inflammatory activation of immune cells leading to chronic inflammation-related ailments. To date, there is minimal evidence showing a direct correlation of salt with cancer incidence and/or cancer-related adverse clinical outcomes. In this review article, we will discuss the recent understanding of the molecular role of salt, and elucidate the apparent double-edged sword nature of the relationship between salt and cancer progression.

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Role of Sodium/Calcium Exchangers in Tumors

Cited by 33 publications

References 62 publications

Emerging Role of TCA Cycle-Related Enzymes in Human Diseases

Emerging Role of TCA Cycle-Related Enzymes in Human Diseases

Advances in Intracellular Calcium Signaling Reveal Untapped Targets for Cancer Therapy

Cancer Salt Nostalgia

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