Role of Single Nucleotide Polymorphisms of Cytokine Genes in Spontaneous Preterm Delivery

Speer, Esther M.; Gentile, Deborah A.; Zeevi, Adriana; Pillage, Gina; Huo, Dezheng; Skoner, David P.

doi:10.1016/j.humimm.2006.08.291

Cited by 54 publications

(41 citation statements)

References 31 publications

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“…(4) Synthesis profiles of cytokines can be considered as either T helper cell type 1 (Th1) responses, promoting cell-mediated immunity and interleukin-2 (IL-2) and interferon gamma (IFN-γ), or Th-2 responses, promoting humoral immunity (IL-4, IL-5, IL-6, IL-10) and Th-3 subset characterized by the transforming growth factor beta (TGF-ß). (5) Cytokine gene polymorphisms have been associated with certain inflammatory and infectious diseases, including some obstetric disorders. (4-7) Polymorphisms likely to occur in regulatory regions of cytokine genes may not only increase susceptibility to some infectious diseases, but also influence the course and prognosis of the disease.…”

Section: Introductionmentioning

confidence: 99%

Association of Tumor Necrosis Factor-alpha and Interleukin-6 Gene Polymorphisms with Preeclampsia

Puppala

Kalpana

Argi

et al. 2016

IJB

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Preeclampsia is a pregnancy-specific syndrome that may be dangerous especially to the fetus. Different cytokines have been found to be elevated in women with preeclampsia and may have possible roles in the development of this disorder. Alleles of the interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-α) genes are associated with preeclampsia in several studies in different populations. The aim of the present study was to investigate the relationship between IL-6 (G174C) and TNF-α (G-308A) gene polymorphisms with preeclampsia in North Coastal Andhra Pradesh of India. The TNFA (-308 A/G) and IL6 (-674G/C) genotypes were determined in 100 preeclamptic women and 100 normal pregnant women as control group, using allele-specific oligonucleotides-polymerase chain reaction method. Data was analyzed using chi-square and Fisher’s exact tests. TNF-α (G-308A) G/G genotype showed a significantly higher frequency among the preeclamptic group than the control group (odds ratio, 0.4603, 95% confidence interval, (0.2521- 0.8405); P = .005). G/A genotype also showed higher frequency among the preeclamptic group compared to control group (odds ratio, 2.508, 95% confidence interval, ((1.341-4.689); P = .001). IL-6 (G174C) genotype significantly higher frequency among the preeclamptic group than the control group (odds ratio, 0.4603, 95% confidence interval, (0.2521- 0.8405); P = .005). The present study might suggest a role for TNF-α (G-308A) and -174 GC of IL-6 genotype in the development of preeclampsia; suggesting that they are of differing genetic predisposition/pathophysiology.

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Section: Introductionmentioning

confidence: 99%

Association of Tumor Necrosis Factor-alpha and Interleukin-6 Gene Polymorphisms with Preeclampsia

Puppala

Kalpana

Argi

et al. 2016

IJB

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“…6 Cytokine gene polymorphisms have been associated with certain inflammatory and infectious diseases, including some obstetric disorders. [7][8][9][10] The relationship between PE and single-nucleotide polymorphisms (SNPs) in cytokine genes has been investigated, but is still unclear. [11][12][13][14][15] The controversial results reported by different investigators may in part be because of selection criteria.…”

Section: Introductionmentioning

confidence: 99%

Cytokine gene polymorphisms in preeclampsia and eclampsia

Lima¹,

Sass

Mattar

et al. 2009

Hypertens Res

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The clinical spectrum of preeclampsia (PE) ranges from mild hypertension to severe vasospasm associated with convulsions and multiple organ damage. The biological factors that determine the progression of PE to eclampsia (E) are unknown. Endothelial cell activation seems related to an impaired maternal immune response. The production of cytokines, IL-10 and TGF-b1, is apparently suppressed, and altered IL-2/IL-10 and TNF-a/IL-10 ratios have been reported in preeclamptic cases. The relationship between PE and cytokine gene polymorphism has been studied, but there are few studies that include eclamptic patients. This study aimed at investigating whether polymorphisms in genes, TNF-a promoter (À308 G4A), IL6 promoter (À174 G4C), IFN-c intron 1 (+874 A4T), IL10 promoters (À1082 A4G), (À819 C4T) and (À592 C4A) and TGF-b1 codon 10 (+869 T4C) and codon 25 (+915 G4C) are associated with E and/or PE. Genotyping was carried out in 266 Mulatto women from the northeastern region of Brazil who were referred to a single maternity hospital: 92 with PE, 73 with E and 101 normotensive controls. The v 2 or Fisher's exact tests were used to compare genotype frequencies. Among the six singlenucleotide polymorphisms (SNPs) studied, we found no difference in genotype frequencies between the groups. There was a higher frequency of IFN-c (+874 A) in eclamptic patients in comparison with that in controls. (70.3 vs. 57.8%, respectively; P¼0.02). There were no other significant differences in allelic frequencies between eclamptic, preeclamptic and control groups We found no independent association between any single SNP and PE or E risk in this population of Mulatto women from the northeastern region of Brazil.

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“…The reported association of the preterm infants' IL-6 (À174) G polymorphism with histological chorioamnionitis does not support this theory. 24 In our opinion the association of the maternal CC genotype with chorioamnionitis and cPVL might be directed more toward the fetal inflammatory response.…”

Section: Discussionmentioning

confidence: 89%

“…Both the maternal CG and GG genotypes have recently been associated with histological or CCA and the infants CC genotype with neonatal infection. 14,24 Results of our previously published data on the IL-6 G(À174)C polymorphism in children with and without cPVL revealed a significant association of the CC and GC genotypes with mental retardation in cPVL, suggesting that the severity of perinatal brain damage might be modified by these genotypes. 15 Recently, two studies have reported on an association of postnatal sepsis and/or necrotizing enterocolitis with white matter injury of the premature infant.…”

Section: Discussionmentioning

confidence: 97%

“…But results from measurements of cytokine concentrations, however, vary depending on the timing in relation to delivery, presence of infection, fetal stress and a multitude of other factors, making their interpretation difficult. 24 Differences of allele frequencies between cases, controls, term infants and reported frequencies of Caucasian adults using the Hardy-Weinberg equilibrium were not significant, allowing us to additionally compare the observed frequencies to these data. We found a significant association between CCA and CC genotypes in a relatively small subgroup of mothers, these results might have been even more pronounced in a larger sample.…”

Section: Discussionmentioning

confidence: 99%

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Maternal interleukin-6 (−174) C/C polymorphism is associated with chorioamnionitis and cystic periventricular leucomalacia of the preterm infant

et al. 2010

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Objective: To evaluate the association between maternal interleukin (IL)-6 G(À174)C polymorphism and cystic periventricular leukomalacia (cPVL) of the preterm newborn.Study Design: After searching a local database, we recruited 132 preterm infants with diagnosis of cPVL, 44 Caucasian mothers were also recruited to participate in this candidate gene-association study at a single teritary care center. Data related to maternal IL-6 G(À174)C polymorphisms were compared with 41 controls, and furthermore compared with data from umbilical cord blood samples from a consecutive birth cohort of 395 healthy newborns, and published data from Caucasian populations including 1104 adults, respectively. In addition, subgroup analysis was performed in cases with either history of preterm premature rupture of the membranes (PPROM) or clinical chorioamnionitis (CCA). IL-6 genotyping was performed using an allele-specific polymerase chain reaction technique.Result: Frequencies of the IL-6 G(À174)C polymorphisms did not differ between cases (GG, 29.5%; GC, 54.5% and CC, 15.9%) and controls (GG, 34.2; GC, 51.2 and CC, 14.6%). Subgroup analysis of 31 cases with history of PPROM (GG, 25.8; GC, 54.8 and CC 19.4%) and controls did not reveal significant differences, but a significantly higher frequency of the CC genotype was found in 23 cases with a history of CCA (34.8%) compared with controls by either univariate (P ¼ 0.032; odds ratio 3.11, 95% confidence interval (CI) 1.11 to 8.68) or multivariate analysis (P ¼ 0.049, odds ratio 2.54, 95% CI 1.01 to 6.45). These data were confirmed by a comparing the CC genotype frequency to 395 term controls (CC 14.7%, P ¼ 0.005) and to the mean CC genotype frequency of 1104 Caucasian adults (CC 15.6%, P<0.0001). Conclusion:Frequencies of the IL-6 G(À174)C polymorphisms did not differ between groups. Subgroup analysis revealed an association of the CC genotype with CCA and cPVL in the preterm newborn.

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Role of Single Nucleotide Polymorphisms of Cytokine Genes in Spontaneous Preterm Delivery

Cited by 54 publications

References 31 publications

Association of Tumor Necrosis Factor-alpha and Interleukin-6 Gene Polymorphisms with Preeclampsia

Association of Tumor Necrosis Factor-alpha and Interleukin-6 Gene Polymorphisms with Preeclampsia

Cytokine gene polymorphisms in preeclampsia and eclampsia

Maternal interleukin-6 (−174) C/C polymorphism is associated with chorioamnionitis and cystic periventricular leucomalacia of the preterm infant

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