Cytokine gene polymorphisms in preeclampsia and eclampsia

Lima, Telmo Henrique Barbosa de; Sass, Nelson; Mattar, Rosiane; Moron, Antônio Fernandes; Torloni, Maria Regina; Franchim, Camila Sommerauer; Daher, Sílvia

doi:10.1038/hr.2009.58

Cited by 58 publications

(45 citation statements)

References 47 publications

(56 reference statements)

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“…2 The development of pre-eclampsia is influenced by both genetic and environmental risk factors, suggesting its multifactorial inheritance. [3][4][5][6][7][8][9][10][11][12] Soluble fms-like tyrosine kinase-1 (sFlt-1), the naturally occurring soluble form of vascular endothelial growth factor receptor 1 (VEGFR1), is produced by alternative splicing of the Flt-1 transcript, resulting in a deletion of the intracellular and transmembrane domains of Flt-1. sFlt-1 binds VEGF and placental growth factor (PlGF) with high affinity, acting as a soluble trap of these angiogenic factors.…”

Section: Introductionmentioning

confidence: 99%

Circulating angiogenic factors determined by electrochemiluminescence immunoassay in relation to the clinical features and laboratory parameters in women with pre-eclampsia

et al. 2010

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The purpose of this study was to determine whether increased serum soluble fms-like tyrosine kinase-1 (sFlt-1) and decreased placental growth factor (PlGF) levels in pre-eclampsia are related to the clinical features and laboratory parameters of the patients, including markers of inflammation, endothelial activation and injury, oxidative stress and trophoblast debris. A total of 54 pre-eclamptic patients, 58 healthy pregnant and 52 healthy non-pregnant women were involved in this case-control study. Serum sFlt-1 and PlGF levels were measured by electrochemiluminescence immunoassay. Serum levels of sFlt-1 and PlGF were significantly higher in pre-eclamptic patients and healthy pregnant women than in healthy non-pregnant women. In addition, pre-eclamptic patients had significantly higher sFlt-1 levels and significantly lower PlGF concentrations compared with healthy pregnant women. According to the subgroup analyses, sFlt-1 levels were significantly higher in severely pre-eclamptic patients than in those with mild pre-eclampsia, whereas pre-eclamptic patients with fetal growth restriction or preterm onset of the disease had significantly lower PlGF concentrations compared with those without intrauterine growth restriction or with a disease onset at term. In the pre-eclamptic group, there were significant positive correlations between serum sFlt-1 levels and systolic and diastolic blood pressure, serum levels of blood urea nitrogen and creatinine, as well as plasma levels of von Willebrand factor antigen, fibronectin and cell-free fetal DNA. Furthermore, serum PlGF concentrations of pre-eclamptic patients showed significant positive correlations with gestational age at disease onset and delivery, as well as with fetal birth weight, and significant inverse correlations with levels of blood urea nitrogen, creatinine and fibronectin. In conclusion, increased serum sFlt-1 and decreased PlGF levels are associated with blood pressure, renal and endothelial dysfunction, trophoblast deportation, as well as with a shorter duration of pregnancy, fetal growth restriction, the severity and preterm onset of the disease in pre-eclampsia. These findings indicate the central role of an angiogenic imbalance in the pathogenesis of this pregnancy-specific disorder.

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Section: Introductionmentioning

confidence: 99%

Circulating angiogenic factors determined by electrochemiluminescence immunoassay in relation to the clinical features and laboratory parameters in women with pre-eclampsia

et al. 2010

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“…Both genetic and environmental factors contribute to the pathogenesis of PE, and gene-environmental interactions may modulate PE risk. [1][2][3][4][5][6][7] Large epidemiological studies have shown that women with a history of early-onset severe PE, which means clinical manifestations occurring before 32 weeks of gestation, show an increased risk of cardiovascular diseases. 8 The renin-angiotensin system has been shown to be important in the pathogenesis of PE.…”

Section: Introductionmentioning

confidence: 99%

G protein-coupled receptor kinase 4 gene variants are not associated with preeclampsia in Northern Han Chinese

Sun

Zhang

2010

Hypertens Res

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Genetic variations in preeclampsia (PE) may affect PE risk. The G protein-coupled receptor kinase 4 (GRK4) gene encodes a member of the Ser/Thr protein kinase family and has been linked to both genetic and acquired hypertension. The aim of this study was to investigate the association between polymorphisms (T-rs1024323-C and T-rs1801058-C) in GRK4 and PE in Northern Han Chinese. Using a case-control design, the association between the GRK4 exon-4 T-rs1024323-C and exon-13 T-rs1801058-C polymorphisms and the risk of PE in Northern Han Chinese was assessed in 105 individuals with PE and 103 age-and area-matched normotensive controls. Genotypes were determined by allelic discrimination. The odds ratio and 95% confidence interval were estimated by binary logistic regression. No association was found between the GRK4 polymorphisms (T-rs1024323-C and T-rs1801058-C) and PE, and there was also no relationship with the severity of PE. The risk of homozygous and heterozygous variant allele carriers of the analyzed single-nucleotide polymorphisms did not differ significantly from that of the homozygous wild-type allele carriers, even after adjustment for age, body mass index, (family) history of hypertension and smoking status. The GRK4 (T-rs1024323-C and T-rs1801058-C) polymorphisms were not associated with a risk of PE in the present Northern Han Chinese study group. Thus, the GRK4 polymorphisms do not seem to have an important role in PE in this population.

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“…CRP is a non-specific biomarker of inflammation, which is closely associated with tissue injury (29). IFN-γ is also a potent pro-inflammatory cytokine resulting in damage of tissue (30). Comprehensive analysis of the anti-inflammatory effects of certain drugs revealed that they reduced the permeability of blood vessels, inhibited inflammatory corpuscle inflow to the inflammatory site and reduced the release of inflammatory factors, which indicated that these effects may be a cascading reaction.…”

Section: Fsc-mentioning

confidence: 99%

Anti-exudation effects of sodium ferulate and oxymatrine combination via modulation of aquaporin 1

Sun

et al. 2017

Experimental and Therapeutic Medicine

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Abstract. The present study aimed to investigate the anti-exudative effects of sodium ferulate combined with oxymatrine in a mouse model of acetic acid-induced peritonitis. Furthermore, the underlying mechanisms were explored by determining the effects of these drugs on the volume and aquaporin 1 (AQP1) expression in vascular endothelial cells on omentum majus and human umbilical vein endothelial cells (HUVEC). Treatment with sodium ferulate combined with oxymatrine was shown to significantly inhibit acetic acid-induced vascular permeability in the peritonitis model mice and furthermore to significantly decrease the optical density of Evans blue, the leukocyte number and the levels of interleukin-6, C-reactive protein and interferon-γ in peritoneal lavage fluid. Pathological analysis of the omentum majus revealed that sodium ferulate and oxymatrine combination treatment significantly alleviated vascular endothelial cell edema and capillary loss. In vitro, flow cytometry revealed that the volume of HUVECs was significantly reduced in the drug treatment groups, as reflected in the forward scatter value. The optical density of AQP1 on the membrane of the vascular endothelial cells on omentum majus and HUVECs were significantly increased in the drug treatment groups compared with the model group. These results indicated that sodium ferulate and oxymatrine combination treatment possessed prominent anti-exudative effects and that the underlying mechanisms are likely to include the improvement of vascular endothelial cellular edema, possibly by upregulation of AQP1 expression on their membrane, which requires further exploration.

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Cytokine gene polymorphisms in preeclampsia and eclampsia

Cited by 58 publications

References 47 publications

Circulating angiogenic factors determined by electrochemiluminescence immunoassay in relation to the clinical features and laboratory parameters in women with pre-eclampsia

Circulating angiogenic factors determined by electrochemiluminescence immunoassay in relation to the clinical features and laboratory parameters in women with pre-eclampsia

G protein-coupled receptor kinase 4 gene variants are not associated with preeclampsia in Northern Han Chinese

Anti-exudation effects of sodium ferulate and oxymatrine combination via modulation of aquaporin 1

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