G protein-coupled receptor kinase 4 gene variants are not associated with preeclampsia in Northern Han Chinese

Sun, Chang; Zhang, Weiyuan

doi:10.1038/hr.2010.57

Cited by 3 publications

(1 citation statement)

References 16 publications

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“…A recent metaanalysis showed that GRK4 and DRD1 gene polymorphisms, rs1024323 GRK4 (OR = 1.826) and rs4532 of DRD1 genes (OR = 1.833), are associated with hypertension in Caucasians and East Asians, respectively [59]. GRK4 polymorphisms are not associated with preeclampsia in northern Han Chinese [147]. However, DRD1 (−48G) and DRD4 (−521T) receptors are associated with preeclampsia in a Polish population [148].…”

Section: Pathogenesis Of Primary Pediatric Hypertensionmentioning

confidence: 99%

Primary Pediatric Hypertension: Current Understanding and Emerging Concepts

et al. 2017

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The rising prevalence of primary pediatric hypertension and its tracking into adult hypertension point to the importance of determining its pathogenesis to gain insights into its current and emerging management. Considering that the intricate control of BP is governed by a myriad of anatomical, molecular biological, biochemical, and physiological systems, multiple genes are likely to influence an individual's BP and susceptibility to develop hypertension. The long-term regulation of BP rests on renal and non-renal mechanisms. One renal mechanism relates to sodium transport. The impaired renal sodium handling in primary hypertension and salt sensitivity may be caused by aberrant counter-regulatory natriuretic and anti-natriuretic pathways. The sympathetic nervous and renin-angiotensin-aldosterone systems are examples of antinatriuretic pathways. An important counter-regulatory natriuretic pathway is afforded by the renal autocrine/paracrine dopamine system, aberrations of which are involved in the pathogenesis of hypertension, including that associated with obesity. We present updates on the complex interactions of these two systems with dietary salt intake in relation to obesity, insulin resistance, inflammation, and oxidative stress. We review how insults during pregnancy such as maternal and paternal malnutrition, glucocorticoid exposure, infection, placental insufficiency, and treatments during the neonatal period have long-lasting effects in the regulation of renal function and BP. Moreover, these effects have sex differences. There is a need for early diagnosis, frequent monitoring, and timely management due to increasing evidence of premature target organ damage. Large controlled studies are needed to evaluate the long-term consequences of the treatment of elevated BP during childhood, especially to establish the validity of the current definition and treatment of pediatric hypertension.

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Section: Pathogenesis Of Primary Pediatric Hypertensionmentioning

confidence: 99%

Primary Pediatric Hypertension: Current Understanding and Emerging Concepts

et al. 2017

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Novel SNPs of WNK1 and AKR1C3 are associated with preeclampsia

Sun

Lin

et al. 2018

Gene

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Association between GRK4 and DRD1 gene polymorphisms and hypertension: a meta-analysis

Zhang¹,

Sun²,

Liu³

et al. 2015

CIA

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The role of GRK4 and DRD1 genes in hypertension remains controversial. We performed a meta-analysis to determine whether GRK4 and DRD1 polymorphisms influence the risk of hypertension and examined the relationship between the genetic variances and the etiology of hypertension. Relevant case-control studies were retrieved by database searches and selected according to established inclusion criteria. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to evaluate the strength of the associations. Meta-regression, subgroup analysis, and sensitivity analysis were performed. A total of 15 articles containing 29 studies were finally included. In the dominant model, rs4532 locus of DRD1 gene was related to hypertension with a pooled OR of 1.353 (95% CI =1.016–1.802, P=0.038). Subgroup analysis for ethnicity showed that rs1024323 locus of GRK4 gene was associated with hypertension in Caucasians (OR =1.826, 95% CI =1.215–2.745, P=0.004) but not in East Asians and Africans. Rs4532 locus was associated with hypertension in East Asians (OR =1.833, 95% CI =1.415–2.376, P,0.001) but not in Caucasians. These data provide possible references for future case-control studies in hypertension.

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G protein-coupled receptor kinase 4 gene variants are not associated with preeclampsia in Northern Han Chinese

Cited by 3 publications

References 16 publications

Primary Pediatric Hypertension: Current Understanding and Emerging Concepts

Primary Pediatric Hypertension: Current Understanding and Emerging Concepts

Novel SNPs of WNK1 and AKR1C3 are associated with preeclampsia

Association between GRK4 and DRD1 gene polymorphisms and hypertension: a meta-analysis

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