Role of silk fibroin and rice starch on some physical properties of hydroxyapatite‐based composites

Abstract

The role of organic blends of silk fibroin (SF) and rice starch (RS) in bone composites based on inorganic hydroxyapatite (HA) is studied. The physical property of HA‐based composites prepared by using the sol–gel method from Ca(OH)2 and H3PO4 in ethanol and water solvent (4 : 1 volume ratio) could be improved by adding SF and RS (1 : 2 weight ratio) to HA (7 : 3 weight ratio). The Fourier transform infrared spectrometer spectrum shows that the SF and RS organic phases are blended homogeneously into the HA crystal structure. Addition of SF increases the pore size and surface area of the composites, as measured by Brunauer–Emmett–Teller method, but their pore volume is slightly decreased. The values of lattice parameters, crystallinity, and crystallite size, as determined from the field‐emission scanning electron microscope, transmission electron microscope, and X‐ray diffractometer results, increase after adding RS. The results are agreeable with the increase of their compressive strength and Young's modulus. Thus, the improved physical property of the prepared HA–SF/RS composites is better suited as bone‐filling material than the standard HA or HA‐based composites with either SF or RS only. Therefore, due to its low cost, biocompatibility, and nontoxicity, this innovative solution could be worth taken under consideration by the restorative dental and orthopedic implants industry. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 42722.

Progress in Hydroxyapatite–Starch Based Sustainable Biomaterials for Biomedical Bone Substitution Applications

“…For hydroxyapatite/chitosan mixtures, starch addition contributed to a better dispersion of ceramic particles within the material 57 . In this work, MPa in hydroxyapatite/starch/chitosan 57,61 . Similarly with hydroxyapatite-starch materials prepared through other methods, materials obtained through precipitation proved their non-toxic behavior and bioactivity through in vitro testing.…”

“…A frequent objective for preparing hydroxyapatite/starch composites is fabrication of scaffold-type products 48,49,57,61,[116][117][118][119][120]131 . A description of these bone reconstruction products and their associated requirements is briefly presented in the next part of this study, dedicated to hydroxyapatite porous products, and in dedicated reviews [132][133][134][135] .…”

“…Silk fibroin is a natural polymer derived from silk which is produced by silkworms. Silk fibroin is nontoxic and hemocompatible and was used in sutures, biosensors, nanofibers, and in bone reconstruction products. , …”

“…The preparation consists in precursor’s homogenization at constant pH (9–11) and mixing until a precipitate was obtained. Composites preparation ends with aging, washing, filtering, and drying at 60–85 °C. , The morpho-structural studies performed on composites obtained through precipitation were aimed to identify the role of starch in mixing hydroxyapatite with other polymers. For hydroxyapatite/chitosan mixtures, starch addition contributed to a better dispersion of ceramic particles within the material .…”

Applications of starch and its derivatives in bioceramics

“…The effect of silk fibroin on the mechanical properties of HA/starch composites was also investigated by Sriudom et al. 41 Using the sol–gel method, a hydroxyapatite composite with a mixture of starch/silk fibroins (1: 2 w/w) at a mass ratio of 7: 3 SF/RS to HA was made. The addition of silk resulted in an increase in the porosity and specific surface of the composite, but gently reduced volume of the pores, while the addition of rice starch (based on SEM, TEM and XRD measurements) resulted in crystallinity, compression strength and Young's modulus increment.…”