Role of sex in familial aggregation of blood pressure in young families

Chen, Yue; Rennie, Donna; Lockinger, Lori A.; Dosman, James A.

doi:10.1002/(sici)1096-8628(19970516)70:2<207::aid-ajmg21>3.0.co;2-m

Am. J. Med. Genet.

1997

DOI: 10.1002/(sici)1096-8628(19970516)70:2<207::aid-ajmg21>3.0.co;2-m

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Role of sex in familial aggregation of blood pressure in young families

Yue Chen

Donna Rennie

Lori A. Lockinger

et al.

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“…Several single-gene abnormalities have been identified for hypertension (O'Byrne and Caulfield, 1998); however, the genetic regulation of blood pressure within the normal range of variation has yet to be delineated. Blood pressure tends to aggregate within families, and the evidence suggests that a significant portion of the familial aggregation is due to the effects of genes (Annest et al, 1983;Hunt et al, 1989;Pérusse et al, 1989;Brandao et al, 1992;Rice et al, 1992;Chen et al, 1997;Gu et al, 1998;An et al, 1999). The heritability (h 2 ) of a trait is defined as the proportion of the total variance in the trait that is attributable to genetic factors.…”

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confidence: 99%

Familial risk of high blood pressure in the Canadian population

Katzmarzyk

Rankinen

Pérusse

et al. 2001

American J Hum Biol

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Familial risk ratios for high blood pressure were estimated in a representative sample of the Canadian population. The sample consisted of 14,069 participants 7-69 years of age from 5,753 families participating in the 1981 Canada Fitness Survey. Resting systolic (SBP) and diastolic (DBP) blood pressures were adjusted for the effects of body mass index using regression procedures. Varying degrees of high blood pressure were defined as the 75(th), 85(th), and 95(th) percentiles of age- and sex-specific values. Age- and sex-standardized risk ratios (SRRs) were calculated comparing the prevalences in the general population to those in spouses and first-degree relatives of probands with high blood pressure. SRRs for the 95(th) percentile were, for SBP and DBP, respectively, 1.37 and 1.45 in spouses and 1.33 and 2.36 in first-degree relatives of probands. SRRs decrease with decreasing percentile cut-offs used to define high blood pressure (95(th) > 85(th) > 75(th)), and SRRs are generally higher in first-degree relatives than in spouses, particularly for DBP. The results indicate significant familial risk for high blood pressure in the Canadian population, and the pattern of SRRs suggests that genetic factors may be responsible for a portion of the risk.

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confidence: 99%

Familial risk of high blood pressure in the Canadian population

Katzmarzyk

Rankinen

Pérusse

et al. 2001

American J Hum Biol

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Evidence for major genetic control of wheeze in relation to history of respiratory allergy: Humboldt family study

et al. 1998

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We report the results of segregation analyses for wheeze before and after a history of respiratory allergy was taken into consideration. The analyses were based on data from 309 nuclear families with 1,053 individuals living in the town of Humboldt, Saskatchewan in 1993, and were performed by using the REGD program of the SAGE package. For adults, information on wheeze and history of respiratory allergy was provided by themselves, and for children, by their parents. Segregation analyses were first conducted before adjustment for history of respiratory allergy. Other covariates were adjusted including sex, current smoking, household exposure to tobacco smoke, and type of house. A single locus model with residual familial effects fit the data well, but none of the Mendelian models (recessive, dominant, and codominant) could be distinguished. The no-parent-offspring-transmission hypothesis was rejected. However, when the variable of respiratory allergy was included in the models as a covariate, both Mendelian and environmental hypotheses were rejected. The Mendelian model had a relatively lower value of Akaike's Information Criterion than did the environmental model (1095.56 versus 1111.24). The data suggest that a single locus gene explains a portion of wheeze that is related to respiratory allergy, and that common environmental factors and/or polygenes also account for a certain familial aggregation of wheeze.

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Role of sex in familial aggregation of blood pressure in young families

Cited by 2 publications

References 4 publications

Familial risk of high blood pressure in the Canadian population

Familial risk of high blood pressure in the Canadian population

Evidence for major genetic control of wheeze in relation to history of respiratory allergy: Humboldt family study

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