“…Ginger compounds may also decrease the expression of some enzymes involved in the lipogenesis, for example, fatty acid synthase and acetyl CoA carboxylase (Okamoto et al, ). - Suppression of adipogenesis : It was reported that treatment with active components of ginger reduced the adipogenesis in adipocytes (3T3‐L1), maybe by decreasing the expression of PPARγ‐associated genes (Ahn & Oh, ; Tzeng & Liu, ). However, there are some controversy toward the agonistic (Ahn & Oh, ; Tzeng & Liu, ) or antagonistic effects (Chung et al, ; de Las, Valero‐Muñoz, Martín‐Fernández, et al, ; Isa, Miyakawa, Yanagisawa, et al, ) of ginger on PPARγ.
- Inhibition of intestinal absorption of dietary fat : It was reported that ginger could suppress the pancreatic lipase enzyme and decrease intestinal absorption of dietary fat that was comparable with the orlistat effect in animal model (Mahmoud & Elnour, ).
- Controlling appetite : It seems that ginger supplementation may decrease the appetite (Ebrahimzadeh Attari et al, ; Mansour et al, ); albeit, there is not a full agreement toward this idea (Abd Allah, Makboul, & Mohamed, ; Wadikar & Premavalli, ). Two conflicting hypotheses regarding ginger's mechanism of action on appetite have been reported.
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