“…Histamine has been shown to be involved in PIB in asthmatic patients ( Abraham et al , 1991 ). Recently, we succeeded in developing an animal model for PIB and revealed that inflammatory mediators contribute to the development of PIB ( Songür et al , 1994 ; Songür, Fujimura, Mizuhashi, Saito & Matsuda, 1995; Fujimura et al , 1996a ; Fujimura, Tsujiura, Songür, Myou & Matsuda, 1996b; Fujimura, Tsujiura, Myou, Ishiura & Matsuda, 1996c). However, the role of alpha‐receptor‐mediated adrenergic nerve activity in this response remains uncertain.…”