Role of SAM-dependent thiol methylation in the renal toxicity of several solvents in mice

Morel, G.; Ban, M.; Hettich, D.; Huguet, Nelly

doi:10.1002/(sici)1099-1263(199901/02)19:1<47::aid-jat536>3.0.co;2-l

Cited by 3 publications

(2 citation statements)

References 42 publications

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“…In murine models, the orally administered bromobenzene was usually administered once in bolus. 15,16,[22][23][24][25] In the case of this protocol, bromobenzene doses smaller than 800-900 mg/kg did not significantly elevate BUN levels, 22,23 while 1495 mg/kg and 2355.15 mg/kg of bromobenzene were found to produce about 2.8-and 2.6-fold increases in the BUN value, respectively. 24,25 In a chronic toxicity study, 50À600 mg/kg bromobenzene added by gavage 5 days/week for 90 days failed to exert significant nephrotoxic effect.…”

Section: Discussionmentioning

confidence: 99%

Protective effect of Cassia fistula fruit extract on bromobenzene-induced nephrotoxicity in mice

Kalantari‬

Jalali

et al. 2011

Hum Exp Toxicol

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The efficacy of a crude hydro-alcoholic extract of Cassia fistula (golden shower tree) fruit to protect the kidney against bromobenzene-induced toxicity was studied. Negative control mice received normal saline; positive control mice were given 460 mg/kg of bromobenzene; Cassia fistula treated mice received 200, 400, 600 and 800 mg/kg of Cassia fistula fruit extract followed by 460 mg/kg bromobenzene (daily by oral gavage for 10 days). On the 11th day, the mice were sacrificed, blood samples were obtained to assess blood urea nitrogen (BUN) and creatinine levels, and kidneys were removed for histological examination. We found that bromobenzene induced significant nephrotoxicity reflected by an increase in levels of BUN and creatinine that was dose dependently prevented by the Cassia fistula fruit extract. The nephroprotective effect of the Cassia fistula fruit extract was confirmed by the histological examination of the kidneys. To the best of our knowledge, this is the first study to demonstrate the protective effect of Cassia fistula in nephrotoxicity.

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Section: Discussionmentioning

confidence: 99%

Protective effect of Cassia fistula fruit extract on bromobenzene-induced nephrotoxicity in mice

Kalantari‬

Jalali

et al. 2011

Hum Exp Toxicol

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“…Meanwhile, these sequences involve a number of pathways of cotton growth and metabolism, such as, for example, S-adenosyl-L-methionine (SAM), which is highly homogenous to M1. SAM is an important intermediate metabolite (Cantoni, 1951;Morel et al, 1999) widely distributed in plants and animals; it plays roles in trans-methyl, trans-sulfur, and trans-aminopropyl group formation, and it participates in the synthesis and energy metabolic pathways of multiple substances (Roje, 2006). Salt stress, one of the most important abiotic stresses, can cause plants to receive and transmit signals to cellular machinery, thereby activating adaptive responses; this is of fundamental importance to biology (Xiong et al, 2002).…”

Section: Discussionmentioning

confidence: 99%

Whole-genome DNA methylation analysis in cotton (Gossypium hirsutum L.)under different salt stresses

Lu¹,

Zhao²,

Wang³

et al. 2015

Turk J Biol

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Salt stress, one of the most important abiotic stresses, is a serious constraint on cotton production. Cytosine methylation in nuclear DNA, an epigenetic modification found in plants, animals, and other organisms, imparts an impressive wealth of heritable information upon the DNA code. Although the cotton reference genome sequence is available to the public, the global DNA methylation data under different salinity stresses are still not available. Here, Zhong07 and ZhongS9612, salt-tolerant and salt-sensitive cultivars, respectively, were selected and methylation-sensitive amplification polymorphism (MSAP) technology was adopted to evaluate DNA methylation level alterations under different salt stresses in cotton. The findings indicated that different salt stresses exerted distinct effects on cotton seedling growth: specifically, both the neutral salt NaCl and alkalescent salt NaHCO 3 showed relatively weak effects, while the alkaline salt Na 2 CO 3 resulted in overt harm to seedlings, significantly darkening their caudexes and roots. MSAP analysis showed that after NaCl, NaHCO 3 , and Na 2 CO 3 treatments, the DNA methylation levels of both leaves and roots decreased first before rising again. The trend in the roots for both type B (methylation) and C (demethylation) was identical to that observed in leaves; however, methylation levels had a different trend with the varying pH values of the salt, showing that the variation of the methylation level and status were mainly induced by the varying PH values of the salt. The analysis of transition type indicated that the main transition type was from hemimethylation to complete methylation (type iii), accounting for 38.10% of the total transitions, showing that complete methylation played a vital function in the process of gene transcription and expression after the salt treatments. The methylation levels of leaves differed from those of roots, indicating tissue specificity. Target sequence analysis showed that DNA methylation level induced by salt stress involves various kinds of metabolic pathways, whose synergistic effect helps cope with salt stresses.

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Molecular mechanisms of 1,2-dichloroethane-induced neurotoxicity

et al. 2023

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Role of SAM-dependent thiol methylation in the renal toxicity of several solvents in mice

Cited by 3 publications

References 42 publications

Protective effect of Cassia fistula fruit extract on bromobenzene-induced nephrotoxicity in mice

Protective effect of Cassia fistula fruit extract on bromobenzene-induced nephrotoxicity in mice

Whole-genome DNA methylation analysis in cotton (Gossypium hirsutum L.)under different salt stresses

Molecular mechanisms of 1,2-dichloroethane-induced neurotoxicity

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