Protective effect of <i>Cassia fistula</i> fruit extract on bromobenzene-induced nephrotoxicity in mice

Kalantari‬, Heibatullah; Jalali, Mohammad Taha; Jalali, Amir; Salimi, Ahmad; Alhalvachi, Foad; Varga, Balázs; Juhász, Béla; Jakab, Ágnes; Kemény-Beke, Ádám; Gesztelyi, Rudolf; Tósaki, Árpád; Zsuga, Judit

doi:10.1177/0960327110396532

Cited by 15 publications

(8 citation statements)

References 25 publications

(33 reference statements)

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“…We found that GM administration causes histopathological lesions in kidney, like glomerular atrophy, cell fragments in the tubules and swollen epithelial cells in proximal and distal convoluted tubules. Histopathological results are in rapport with the previous studies (Kalantari et al, 2011). In addition, the protective effects of cinnamon and/or parsley oils were confirmed by histopathological studies of kidney which indicates considerable improvement in proximal and distal convoluted tubules and glomerular atrophy in pre-treated groups (Fig.…”

Section: Resultssupporting

confidence: 88%

Nephroprotective Effects of Cinnamon and/or Parsley Oils against Gentamicin-Induced Nephrotoxicity in Rats

Elkomy¹,

Aboubakr²,

Medhat³

et al. 2020

J. Anim. Vet. Adv.

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In the present study, the nephroprotective potentials of cinnamon and/or parsley oils was assessed on gentamicin (GM)-induced nephrotoxicity in rats. About 49 male rats were assigned randomly into 7 equal groups (7 rats each). Group 1-3: were orally administered normal saline, cinnamon oil (400 mg kgG 1 b.wt.) and parsley oil (200 mg kgG 1 b.wt.), respectively, once daily for 30 consecutive days. Group 4: rats in this group were intraperitoneally injected with GM (100 mg kgG 1 b.wt.) in the last 10 days (20-30 th day) of the experiment. Group 5: rats in this group were given cinnamon and GM while rats in group 6 were administered parsley and GM. Group 7: rats in this group were administered cinnamon and parsley plus GM. At the end of the experiment, rats were sacrificed, serum samples and kidney specimens were collected for biochemical and oxidative status evaluation. Rats administered GM alone showed significant increases in serum concentrations of creatinine, urea and glucose while renal tissue levels of superoxide dismutase, catalase and glutathione reductase were significantly declined. Additionally, the malondialdehyde level was significantly elevated in kidney tissues. Also, GM administration caused renal histopathological alterations. The altered levels of various parameters provoked by GM toxicity were restored towards normal levels by cinnamon and/or parsley oils administration. These results suggested the nephroprotective potentials of cinnamon and/or parsley oils in rats, probably triggered by their antioxidant phytoconstituents.

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Section: Resultssupporting

confidence: 88%

Nephroprotective Effects of Cinnamon and/or Parsley Oils against Gentamicin-Induced Nephrotoxicity in Rats

Elkomy¹,

Aboubakr²,

Medhat³

et al. 2020

J. Anim. Vet. Adv.

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“…37 It may be assumed that renal tubular function is affected more by bromobenzene-induced toxicity than glomerular filtration. 5 In the present study, intragastric intubation of bromobenzene (alone) once instigated renal injury that was evidenced by the elevation of serum urea, uric acid and creatinine and depletion in urinary levels of urea, uric acid and creatinine. From the results, it can be observed that pre-treatment of W. somnifera for 8 days to bromobenzene treated rats was able to normalize the levels of serum urea, uric and uric acid thus restoring the renal function and this may be due to some of its active components like alkaloids, sitoinosides and steroidal lactones.…”

Section: Discussionmentioning

confidence: 99%

“…Catalase (CAT) was assayed according to the method of Sinha 18 and chromic acetate produced by the action of catalase on dichromate acetic reagent was measured spectrophotometrically at 610 nm. Glutathione peroxidase (GPx) was assayed by the method of Rotruk et al 19 based on the reaction between glutathione remaining after the action of GPx 5,5 0 -dithiobis-(2-nitrobenzoic acid) to form a complex that has maximum absorption at 412 nm. Glutathione-s-transferase or GST 20 was measured using 1-Chloro-2, 4-dinitrobenzene as substrate and reduced glutathione was evaluated by the method of Moron et al 21 Total protein was estimated using the method of Lowry's et al 22 using bovine serum albumin as standard.…”

Section: Evaluation Of Oxidative Stressmentioning

confidence: 99%

“…3 One possible protective strategy would be to enrich tissue mitochondria with antioxidants thereby limiting mitochondrial oxidative damage which has been proven by several studies. [4][5][6] Withania somnifera or Ashwagandha or Indian Ginseng (dunal Solanaceae) is mainly cultivated in drier parts of India and all over the world. It has been found to exhibit antioxidant, 7 anti-arthritic, 8 anti-cancer, 9 anti-inflammatory 10 and anti-ageing properties.…”

Section: Introductionmentioning

confidence: 99%

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Protective effect of administration ofWithania somiferaagainst bromobenzene induced nephrotoxicity and mitochondrial oxidative stress in rats

2014

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Background: The present study was conducted to elucidate the protective role of Withania somnifera against bromobenzene induced nephrotoxicity and mitochondrial dysfunction in rats. Methods: In this study, Wistar albino rats of either sex were divided into six groups consisting of six animals each. The first one was control, those in group II received bromobenzene (10 mmol/kg, intragastric intubation) once, but group III and IV animals received W. somnifera (250 and 500 mg/kg, orally), respectively for 8 days followed by bromobenzene once on the 8th day and silymarin (100 mg/kg, orally) was given for 8 days to group V animals and then bromobenzene on the last day. Group VI animals received only W. somnifera (500 mg/kg) for 8 days. Results: The levels of renal lipid peroxidation, lysosomal enzymes and glycoprotein were increased significantly (p50.05) in the bromobenzene alone treated rats and antioxidant status and mitochondrial enzymes were found to be decreased, when compared to the control group. The levels of kidney functional markers (urea, uric acid and creatinine) were also found to be abnormal in serum of bromobenzene alone treated rats. On the other hand, administration of W. somnifera (250 and 500 mg/kg) along with bromobenzene offered a significant dose-dependent protection to the biochemical alterations as observed in the bromobenzene alone treated rats, which was also evidenced by histopathology. Conclusion: Thus, the oral administration of W. somnifera significantly protected against the bromobenzene induced nephrotoxicity and renal mitochondrial dysfunction in rats.

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“…Both extracts exhibited significant antioxidant activity in DPPH, Nitric oxide and Hydroxyl radical induced invitro assay methods. Both extracts showed Dose-Dependent protective effect against lipid peroxidation and free radical generation in liver and kidney homogenates 24,25 . Antioxidant activity of Cassia fistula Linn) flowers in alloxan induced diabetic rats 26 .…”

Section: Ayurvedic Medicine Usesmentioning

confidence: 99%

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2014

IJPSR

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Protective effect of Cassia fistula fruit extract on bromobenzene-induced nephrotoxicity in mice

Cited by 15 publications

References 25 publications

Nephroprotective Effects of Cinnamon and/or Parsley Oils against Gentamicin-Induced Nephrotoxicity in Rats

Nephroprotective Effects of Cinnamon and/or Parsley Oils against Gentamicin-Induced Nephrotoxicity in Rats

Protective effect of administration ofWithania somiferaagainst bromobenzene induced nephrotoxicity and mitochondrial oxidative stress in rats

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