Role of resveratrol in regulation of cellular defense systems against oxidative stress

Truong, Van-Long; Jun, Mira; Jeong, Woo-Sik

doi:10.1002/biof.1399

Cited by 259 publications

(169 citation statements)

References 160 publications

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“…Truong et al suggested two different mechanisms for describing the protective role of resveratrol against oxidative damage. They proposed that resveratrol directly scavenges ROS and organic radicals with mechanisms of hydrogen atom transfer and sequential proton loss electron transfer, and indirectly could induce the expression of diverse antioxidant enzymes such as heme oxygenase 1, CAT, GPx, and SOD as well as enhancing GSH concentrations (Truong et al, 2018). Accordingly, it appears that protective effects of resveratrol that were observed in our study may be explained by these two proposed mechanisms.…”

Section: Discussionsupporting

confidence: 56%

Protective effects of resveratrol against X-ray irradiation by regulating antioxidant defense system

et al. 2018

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Ionizing radiation interacts with biomolecules to produce free radicals, which can damage all components of the cell. The aim of this study was to evaluate the protective effects of different doses of resveratrol against X-ray-induced damage in male rat. The animals were divided into five groups, each composed of six rats: two groups as control groups received saline or ethanol (ethanol in saline, 25%, V/Vas a vehicle). Two groups received resveratrol (5 and 10 mg/kg.bwt) for 30 days before X-ray exposure. One group received X-ray. The rats were sacrificed 24 h after the last exposure, blood samples were collected and serum level of malondialdehyde (MDA), total antioxidant capacity (TAC), and the activities of superoxide dismutase (SOD) and catalase (CAT) were measured by spectrophotometric method. X-ray irradiation significantly increased the levels of MDA and decreased TAC as well as SOD activity as compared with control groups. Furthermore, resveratrol pretreatment led to remarkable decrease in MDA concentration and increase in the activities of SOD and CAT as well as TAC compared to those of controls. Our results revealed antioxidant properties of resveratrol and suggest it as a potent radioprotector to ameliorate X-irradiation induced damage in the body.

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Section: Discussionsupporting

confidence: 56%

Protective effects of resveratrol against X-ray irradiation by regulating antioxidant defense system

et al. 2018

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“…Surprisingly, the effects of this combination were much higher than with the compounds alone. The selection of resveratrol to be associated with STX was based on its properties to reduce ROS and inflammation, described in alopecia . We showed that a pre‐treatment with resveratrol protected the hair matrix cells when exposed to a generator of ROS, which is of importance as the hair matrix cells are the key player to produce the hair shaft and must be preserved to guarantee the hair density.…”

Section: Discussionmentioning

confidence: 99%

A combination of pyridine‐2, 4‐dicarboxylic acid diethyl ester and resveratrol stabilizes hypoxia‐inducible factor 1‐alpha and improves hair density in female volunteers

Juchaux

Sellathurai

Perrault

et al. 2020

Intern J of Cosmetic Sci

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Objective The aim of this study was first to demonstrate that a combination of pyridine‐2, 4‐dicarboxylic acid diethyl ester and resveratrol could synergize in vitro on biological pathways associated with hair growth and then to demonstrate the benefit on hair density in a clinical study. Methods The effects of pyridine‐2, 4‐dicarboxylic acid diethyl ester and resveratrol directly on the hypoxic inducible factor‐1α protein (HIF‐1α) and related genes expression were demonstrated on keratinocytes in culture in vitro using western‐blot analysis and real time quantitative polymerase chain reaction analysis. The effect of resveratrol against oxidative stress induced by hydrogen peroxide treatment was studied in hair follicle and hair matrix cells in vitro using the sensitive probe Dichloro‐dihydro‐fluorescein diacetate (DCFH‐DA). Finally, a randomized clinical study on hair density was conducted on 79 Caucasian female subjects to assess the effect of this combination of actives. Results Pyridine‐2, 4‐dicarboxylic acid diethyl ester and resveratrol stabilized HIF‐1a protein and increased the expression of HIF‐1α target genes. Resveratrol significantly reduced the oxygen peroxide‐induced oxidative stress generated in hair follicle and hair matrix cells. The clinical study showed that a topical treatment with the combination significantly increased the hair density on women from 1.5 months. Conclusion In addition to the antioxidant properties of resveratrol, the association of pyridine‐2, 4‐dicarboxylic acid diethyl ester and resveratrol revealed a synergistic effect on the HIF‐1α pathway. The results of the clinical study confirmed the importance of such a combination to increase the hair density.

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“…They can not only directly scavenge free radicals and quench singlet oxygen, but also indirectly activate endogenous Nrf2/ARE signaling pathways. Truong et al have reviewed the two ways of resveratrol in regulating cellular defense systems against oxidative stress [30]. Kanlaya et al found that EGCG protects renal tubular cells from oxalate-induced epithelial mesenchymal transition via Nrf2 pathway [31].…”

Section: Discussionmentioning

confidence: 99%

Floridoside Exhibits Antioxidant Properties by Activating HO-1 Expression via p38/ERK MAPK Pathway

Niu

Zhou

et al. 2020

Marine Drugs

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Floridoside is a low-molecular-weight organic compound, which can be accumulated by red algae under stressful conditions to protect cells via its excellent antioxidant properties. In the present study, we investigated the antioxidant mechanism of floridoside toward human hepatocyte L-02 cells. We found that floridoside had no toxicity to L-02 cells, and no reactive oxidative species were induced by it either. However, the expression of hemoxygenase-1 (HO-1) protein was up-regulated upon exposure to floridoside, and two antioxidant enzymes, superoxide dismutase (SOD) and GSH-Px, were activated by floridoside. Moreover, we investigated the pathway involved in the production of these antioxidants, p38/extracellular signal-regulated kinase (ERK) MAPK-nuclear factor-erythroid-2-related factor 2 (Nrf2) pathway. ERK1/2 and p38 phosphorylation, nuclear translocation of Nrf2, and activation of ARE luciferase activity were observed upon exposure to floridoside. siRNA interference and inhibitor treatment suppressed the HO-1 expression and the phosphorylation of ERK1/2 and p38, respectively. These results indicated that floridoside exerted its antioxidant activity by activating HO-1 expression via p38/ERK MAPK-Nrf2 pathway in human hepatocyte L-02 cells.

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Role of resveratrol in regulation of cellular defense systems against oxidative stress

Cited by 259 publications

References 160 publications

Protective effects of resveratrol against X-ray irradiation by regulating antioxidant defense system

Protective effects of resveratrol against X-ray irradiation by regulating antioxidant defense system

A combination of pyridine‐2, 4‐dicarboxylic acid diethyl ester and resveratrol stabilizes hypoxia‐inducible factor 1‐alpha and improves hair density in female volunteers

Floridoside Exhibits Antioxidant Properties by Activating HO-1 Expression via p38/ERK MAPK Pathway

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