Protective effects of resveratrol against X-ray irradiation by regulating antioxidant defense system

Abstract

Ionizing radiation interacts with biomolecules to produce free radicals, which can damage all components of the cell. The aim of this study was to evaluate the protective effects of different doses of resveratrol against X-ray-induced damage in male rat. The animals were divided into five groups, each composed of six rats: two groups as control groups received saline or ethanol (ethanol in saline, 25%, V/Vas a vehicle). Two groups received resveratrol (5 and 10 mg/kg.bwt) for 30 days before X-ray exposure. One group received X-ray. The rats were sacrificed 24 h after the last exposure, blood samples were collected and serum level of malondialdehyde (MDA), total antioxidant capacity (TAC), and the activities of superoxide dismutase (SOD) and catalase (CAT) were measured by spectrophotometric method. X-ray irradiation significantly increased the levels of MDA and decreased TAC as well as SOD activity as compared with control groups. Furthermore, resveratrol pretreatment led to remarkable decrease in MDA concentration and increase in the activities of SOD and CAT as well as TAC compared to those of controls. Our results revealed antioxidant properties of resveratrol and suggest it as a potent radioprotector to ameliorate X-irradiation induced damage in the body.

Nuclear and Radiological Emergencies: Biological Effects, Countermeasures and Biodosimetry

“…Resveratrol (RES) has demonstrated potential anti-cancer, antioxidant, neuroprotective, anti-inflammatory and cardioprotective effects. It is noteworthy that RES serves as a scavenger of O 2 •− , • OH and metal-induced radicals, and increases the activity of many antioxidant enzymes [ 131 ]. RES significantly reduced radiation-induced chromosome aberration [ 132 ], DNA damage [ 133 ] and apoptosis, supported cell regeneration, and induced repression of the NLRP-3 inflammasome subset [ 134 ].…”

Protective Potentials of Alpha-Lipoic Acid against Ionizing Radiation-Induced Brain Damage in Rats

“…The release of proinflammatory and profibrosis cytokines can increase the expression and activity of NOX2 and NOX4, leading to ROS production and oxidative stress [63]. The administration of some adjuvants to enhance antioxidant defense capacity is an intriguing approach for protecting normal tissues against the ionizing radiation [64]. However, some experiments have suggested the inhibition of prooxidant enzymes as a strategy for protecting normal cells/tissues [14,65,66].…”