Role of respiratory syncytial virus in early hospitalizations for respiratory distress of young infants with cystic fibrosis

Abman, Steven H.; Ogle, John W.; Butler–Simon, Nancy; Rumack, Carol M.; Accurso, Frank J.

doi:10.1016/s0022-3476(88)80008-8

Cited by 228 publications

(144 citation statements)

References 21 publications

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confidence: 99%

“…Viruses have been detected in 40-52% of patients with pulmonary exacerbations compared with only 9-18% of patients in stable clinical condition (1)(2)(3). Viruses detected include rhinovirus (RV), influenza A/B, respiratory syncytial virus (RSV), parainfluenza, adenovirus and human metapneumovirus, with RV being the most common (1)(2)(3)(4)(5)(6)(7). Although the frequency of viral isolation is similar in normal healthy control subjects and patients with CF, the clinical impact of viral infection in patients with CF is higher than in control subjects (5,(8)(9)(10).…”

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Differential Responses to Rhinovirus- and Influenza-associated Pulmonary Exacerbations in Patients with Cystic Fibrosis

et al. 2014

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Rationale: The mechanism by which viruses cause exacerbations of chronic airway disease and the capacity of patients with cystic fibrosis (CF) to respond to viral infection are not precisely known.Objectives: To determine the antiviral response to infection in patients with CF.Methods: Sputum was collected from patients with CF with respiratory exacerbation. Viruses were detected in multiplex polymerase chain reaction (PCR)-based assays. Gene expression of 84 antiviral response genes was measured, using a focused quantitative PCR gene array. Measurements and Main Results:We examined 36 samples from 23 patients with respiratory exacerbation. Fourteen samples tested virus-positive and 22 virus-negative. When we compared exacerbations associated with rhinovirus (RV, n = 9) and influenza (n = 5) with virus-negative specimens, we found distinct patterns of antiviral gene expression. RV was associated with greater than twofold induction of five genes, including those encoding the monocyte-attracting chemokines CXCL10, CXCL11, and CXCL9. Influenza was associated with overexpression of 20 genes, including those encoding the cytokines tumor necrosis factor and IL-12; the kinases MEK, TBK-1, and STAT-1; the apoptosis proteins caspase-8 and caspase-10; the influenza doublestranded RNA receptor RIG-I and its downstream effector MAVS; and pyrin, an IFN-stimulated protein involved in influenza resistance. Conclusions:We conclude that virus-induced exacerbations of CF are associated with immune responses tailored to specific infections. Influenza induced a more potent response consisting of inflammation, whereas RV infection had a pronounced effect on chemokine expression. As far as we are aware, this study is the first to compare specific responses to different viruses in live patients with chronic airway disease.

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Differential Responses to Rhinovirus- and Influenza-associated Pulmonary Exacerbations in Patients with Cystic Fibrosis

et al. 2014

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“…Cigarette smoking is more prevalent in low SES groups, 11 and exposure to environmental tobacco smoke has been linked to decreased pulmonary function in children with CF. 12 Respiratory virus infections, particularly with respiratory syncytial virus, 13 may occur earlier and more frequently in economically disadvantaged children, initiating airway inflammation at a younger age.…”

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confidence: 99%

Marked improvement in cystic fibrosis lung disease and nutrition following change in home environment

2009

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“…Up to 40% of pulmonary exacerbations are attributed to viruses in individuals with CF [76][77][78] and are associated with a persistent decrease in lung function [76,[78][79][80] , prolonged hospital admission and increased likelihood of earlier acquisition of Pseudomonas aeruginosa colonization [80,81] . A distinction between upper and lower respiratory tract viral infections exists and in CF, increased incidences of lower respiratory tract viral infections are associated with poorer outcomes [79] .…”

Section: The Role Of Viral Infection In Cfmentioning

confidence: 99%

Toll-like receptors as therapeutic targets in cystic fibrosis

Greene

Branagan

McElvaney³

2008

Expert Opinion on Therapeutic Targets

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Role of respiratory syncytial virus in early hospitalizations for respiratory distress of young infants with cystic fibrosis

Cited by 228 publications

References 21 publications

Differential Responses to Rhinovirus- and Influenza-associated Pulmonary Exacerbations in Patients with Cystic Fibrosis

Differential Responses to Rhinovirus- and Influenza-associated Pulmonary Exacerbations in Patients with Cystic Fibrosis

Marked improvement in cystic fibrosis lung disease and nutrition following change in home environment

Toll-like receptors as therapeutic targets in cystic fibrosis

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