Marked improvement in cystic fibrosis lung disease and nutrition following change in home environment

Gupta, Atul; Urquhart, Donald; Rosenthal, Mark

doi:10.1258/jrsm.2009.s19010

Cited by 6 publications

(6 citation statements)

References 19 publications

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“…These findings are vividly illustrated by a case of marked improvement in CF lung disease following change in home environment, anecdotally reported by Gupta et al [45]. The case emphasizes that factors other than genotype have a significant effect on CF phenotype.…”

Section: Pulmonary and Nutritional Outcomesmentioning

confidence: 83%

Socioeconomic status and health outcomes: cystic fibrosis as a model

Oates

Schechter

2016

Expert Review of Respiratory Medicine

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CF disease progression and outcomes are influenced by a number of nongenetic factors, such as material well-being, educational attainment, living and working conditions, physical environment and exposures, family environment, social support, health behaviors, and health care. This review discusses pathways by which financial, educational, and social resources are translated into health advantages in CF. Expert commentary: To achieve equitable CF outcomes, the contribution of nongenetic factors must be emphasized, highlighting the mechanisms through which the social and physical environments influence disease variability.

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Section: Pulmonary and Nutritional Outcomesmentioning

confidence: 83%

Socioeconomic status and health outcomes: cystic fibrosis as a model

Oates

Schechter

2016

Expert Review of Respiratory Medicine

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“… 8 The clinical course of CF is influenced by frequent pulmonary exacerbations that cause structural and functional damage to the lungs, 9 highlighting the importance of therapeutic interventions that preserve lung function. 4 Factors affecting pulmonary function include patient age, body mass index (BMI) 10 , 11 female sex, PI, 12 , 13 CF-related diabetes (CFRD), CF-associated liver disease (CFLD), 12 and respiratory bacterial infections 14 requiring repeated and long courses of antibiotics. 15 Because of a lack of neonatal screening in Romania, CF patients are diagnosed late, subsequently fail to thrive, and have an increased frequency of chronic infections in addition to altered lung function.…”

Section: Introductionmentioning

confidence: 99%

Factors Influencing Lung Function in Patients with Cystic Fibrosis in Western Romania

Dediu¹,

Ciucă²,

Marc³

et al. 2021

JMDH

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Purpose The aim of this cross-sectional study was to identify the major factors influencing pulmonary function in CF patients from western side of Romania. Patients and Methods The study enrolled 51 patients with CF between the ages of 6 and 27.8 years who were monitored at regular visits to the National Cystic Fibrosis Centre and Pius Branzeu County Hospital in Timisoara, Romania, over a period of 2 years. The relationships between lung function, as measured by forced expiratory volume in 1 s (FEV 1 ), with patient age, sex, body mass index (BMI), pancreatic insufficiency (PI), microbial infection, CF-related diabetes (CFRD), CF-associated liver disease (CFLD), and physical activity <30 min/day, were evaluated by multivariate regression analysis. Results The results showed that FEV1 was 0.32% higher for each increase in percentile of BMI (95% confidence interval: 0.034–0.619). In addition, mean FEV 1 was 1.52% lower with every year rise of age. PI and female sex increased the risk of impaired lung function (FEV 1 <60%). The factors most closely correlated with pulmonary function in pediatric CF patients were current age (negative) and BMI (positive). Conclusion The findings of this study, in combination with what is known from other studies in CF, suggest that a better nutritional status and infection prophylaxis should be part of a comprehensive clinical management strategy for pediatric CF in Romania.

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“…Psychosocial experiences in early childhood are important determinants of future health and well‐being, and may significantly alter the clinical trajectory of children with chronic disease through numerous bio‐psychosocial interactions . The role of psychosocial factors in the environment of young children as moderators of health‐care use, and health outcomes are widely recognised, but poorly understood in cystic fibrosis (CF).…”

mentioning

confidence: 99%