Role of remnant cholesterol in IHD

Mearns, Bryony M.

doi:10.1038/nrcardio.2013.132

Cited by 7 publications

(6 citation statements)

References 1 publication

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“…By the virture of their larger size, remnant cholesterol carries 5 to 20 times as much cholesterol pe particle as LDL-C [9]. Importantly, unlike native LDL-C, remnant cholesterol can up-regulate the expression of scavenger receptors and thus promoting foam cell formation [10]. Thus, genetic studies of variants associated with elevated remnant cholesterol levels show that an increment of 1 mmol/L in levels of non-fasting remnant cholesterol associates with a 2.8-fold increased risk of CAD [8].…”

Section: Introductionmentioning

confidence: 99%

Predictive value of non-fasting remnant cholesterol for short-term outcome of diabetics with new-onset stable coronary artery disease

Liu

Yan

et al. 2017

Lipids Health Dis

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BackgroundThe relationship between non-fasting remnant cholesterol and cardiovascular outcome in the era of potent statin therapy remained to be elucidated.MethodsA cohort study of three hundred and twenty eight diabetics diagnosed with new-onset stable coronary artery disease (CAD) by coronary angiography were enrolled. All cases were followed up for an average duration of twelve months. The association between baseline remnant cholesterol levels and major cardiovascular outcomes were evaluated using the receivers operating characteristic (ROC) curves and Cox proportional hazards regression analysis.ResultsDuring a period of 12-month’s follow-up, 14.3% patients (47/328) underwent pre-specified adverse outcomes. The remnant cholesterol associated with high sensitivity C-reactive protein, neutrophil count and fibrinogen (R 2 = 0.20, 0.12 and 0.14; P = 0.000, 0.036 and 0.010 respectively). Area under the ROC curves (AUC) indicated discriminatory power of the remnant cholesterol to predict the adverse outcomes for this population (AUC = 0.64, P < 0.005). Kaplan-Meier curve suggested that the lower levels of remnant cholesterol showed relatively lower cardiac events for diabetic patients with stable CAD (Log rank X 2 = 8.94, P = 0.04). However, according to multivariate Cox proportional hazards regression, apart from hemoglobin A1C (Hazard ratio [H.R.] =1.38, 95% CI: 1.14–1.66, P = 0.001) and Gensini scores (H.R. = 1.00, 95% CI: 1.00–1.02; P = 0.035), remnant cholesterol did not qualify as an independent predictor of adverse prognosis in these settings (H.R. = 1.05, 95% CI: 0.46–2.37, P = 0.909).ConclusionsNon-fasting remnant cholesterol was associated with inflammatory biomarkers and high incidence of revascularization, but not qualified as an independent predictor for short-term prognosis of diabetics with new-onset stable coronary artery disease.

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Section: Introductionmentioning

confidence: 99%

Predictive value of non-fasting remnant cholesterol for short-term outcome of diabetics with new-onset stable coronary artery disease

Liu

Yan

et al. 2017

Lipids Health Dis

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“…RC could be penetrable to the arterial wall, be phagocytosed by macrophages, and result in the formation of foam cells. Furthermore, RC speeds up the creation of foam cells via upregulating scavenger receptor expressions 26 . Atherosclerosis lowers blood circulation to the pancreas and impairs pancreatic function, which reduces insulin secretion levels and causes hyperglycemia 28 .…”

Section: Discussionmentioning

confidence: 99%

“…Numerous investigations have shown a strong link between atherosclerosis and hyperglycemia. [22][23][24] Elevated RC levels aided in the atherosclerosis progression, 10,[25][26][27] which causes hyperglycemia. RC could be penetrable to the arterial wall, be phagocytosed by macrophages, and result in the formation of foam cells.…”

Section: Potential Mechanismsmentioning

confidence: 99%

“…Furthermore, RC speeds up the creation of foam cells via upregulating scavenger receptor expressions. 26 Atherosclerosis lowers blood circulation to the pancreas and impairs pancreatic function, which reduces insulin secretion levels and causes hyperglycemia. 28 Atherosclerosis also causes liver dysfunction and reduces glycogen production in the liver, thus leading to hyperglycemia.…”

Section: Potential Mechanismsmentioning

confidence: 99%

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Remnant cholesterol is independently associated with diabetes, even if the traditional lipid is at the appropriate level: A report from the REACTION study

Zhou

Wang

et al. 2023

Journal of Diabetes

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Background The association between remnant cholesterol (RC) and diabetes remains unclear because of limited study and data. This study attempted to explore the association between RC and diabetes in a large sample, multicenter general population. Methods The current study included 36 684 participants from eight provinces across China. Subjects were quartered according to the RC quartile. Logistic regression analysis was used to evaluate the association between RC and diabetes. Results After adjusting for potential confounding factors, RC was still significantly associated with diabetes (Q4: odds ratio [OR]:1.147, 95% confidence interval [CI]: 1.049–1.254, p = .003). In addition, RC and diabetes were still significantly associated when triglycerides (TG) were <1.7 mmol/L (Q4: OR: 1.155, 95% CI: 1.005–1.327, p = .042), low‐density lipoprotein cholesterol (LDL‐C) <3.4 mmol/L (Q4: OR: 1.130, 95% CI: 1.011–1.264, p = .032), or HDL‐C (high‐density lipoprotein cholesterol) ≥1.0 mmol/L (Q4: OR: 1.116, 95% CI: 1.007–1.237, p = .037). In the stratification analysis, elevated RC was significantly associated with diabetes in subjects with systolic blood pressure (SBP) <140 mm Hg and diastolic blood pressure (DBP) <90 mm Hg, 60 ≤ estimated glomerular filtration rate (eGFR) ≤90 ml/min per 1.73 m2, younger than 55 years old and female. Conclusion In the Chinese community, RC is significantly correlated with diabetes, even when TG, LDL‐C, or HDL‐C were controlled within the appropriate range recommended by the guidelines.

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“…It is reported that RC can promote the formation of foam cells and cause atherosclerosis in many ways. In addition, RC is also involved in the inflammation of the arterial wall, resulting in vascular injury [ 33 – 35 ]. Aside from being closely related to cardiovascular disease, several recent studies have found that higher levels of RC also significantly increase the risk of diabetic complications, hypertension and NAFLD [ 17 – 20 ].…”

Section: Discussionmentioning

confidence: 99%

Remnant cholesterol/high-density lipoprotein cholesterol ratio is a new powerful tool for identifying non-alcoholic fatty liver disease

Zou

Kuang

et al. 2022

BMC Gastroenterol

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Background Remnant cholesterol/high-density lipoprotein cholesterol (RC/HDL-C) ratio has been shown to be a good predictor of metabolic disease risk, but no studies have further investigated the role of RC/HDL-C ratio in non-alcoholic fatty liver disease (NAFLD) patients. Methods The participants were 14,251 adults who underwent a physical examination, all of whom underwent abdominal ultrasonography to determine whether they had NAFLD. Receiver operating characteristic curve analysis and multivariate logistic regression models were used to assess the association between the RC/HDL-C ratio and the risk of NAFLD. Results Multivariate logistic regression analysis showed that after fully adjusting the confounding factors, the higher RC/HDL-C ratio was independently positively correlated with the risk of NAFLD. Interaction tests suggested that the effect of RC/HDL-C ratio on NAFLD was significantly affected by sex. Additionally, receiver operating characteristic curve analysis showed that the area under the curve of RC/HDL-C ratio for identifying NAFLD was 0.82, which was significantly higher than that of other conventional lipid parameters. Conclusions This study indicates for the first time that the higher RC/HDL-C ratio in the general population may be closely related to the increased risk of NAFLD.

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Role of remnant cholesterol in IHD

Cited by 7 publications

References 1 publication

Predictive value of non-fasting remnant cholesterol for short-term outcome of diabetics with new-onset stable coronary artery disease

Predictive value of non-fasting remnant cholesterol for short-term outcome of diabetics with new-onset stable coronary artery disease

Remnant cholesterol is independently associated with diabetes, even if the traditional lipid is at the appropriate level: A report from the REACTION study

Remnant cholesterol/high-density lipoprotein cholesterol ratio is a new powerful tool for identifying non-alcoholic fatty liver disease

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