Predictive value of non-fasting remnant cholesterol for short-term outcome of diabetics with new-onset stable coronary artery disease

Liu, Hong; Yan, Xiao-Ni; Lu, Zhenhua; Fan, Yuxin; Ye, Fei; Wu, Qiong; Luo, Suxin; Yang, Bo; Li, Jianjun

doi:10.1186/s12944-017-0410-0

Cited by 28 publications

(18 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similar results were also found in obese adolescents [11, 12]. A higher TyG index was significantly associated with a higher risk of diabetes [16, 24, 25], hypertension [17, 26] and metabolic syndrome [27]. In the present study, we also found that the TyG index was significantly correlated with cardiometabolic risk factors.…”

Section: Discussionsupporting

confidence: 90%

“…Min et al and ki-Bum et al reported that the TyG index was independently associated with arterial stiffness in 3587 subjects and 2560 subjects, respectively, in Korean populations [14, 15]. A few prospective studies have shown that the TyG index was associated with new-onset diabetes [16], hypertension [17] and cardiovascular events [18]. It is well established that aging is significantly associated with the development of IR [19].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Association between macro- and microvascular damage and the triglyceride glucose index in community-dwelling elderly individuals: the Northern Shanghai Study

Zhao

Chen

et al. 2019

Cardiovasc Diabetol

189

194

View full text Add to dashboard Cite

Background: It has been reported that the triglyceride-glucose (TyG) index may serve as a simple and credible surrogate marker of insulin resistance (IR). However, its association with macrovascular and microvascular damage is unclear. Accordingly, the objective of the present study is to investigate the association of macrovascular and microvascular damage with the TyG index. Methods: A total of 2830 elderly participants from the Northern Shanghai Study (NSS) were enrolled. The TyG index was calculated as ln[fasting triglycerides (mg/dL) × fasting glucose (mg/dL)/2]. Parameters of vascular damage, including carotid-femoral pulse wave velocity (cf-PWV), brachial-ankle pulse wave velocity (ba-PWV), ankle-brachial index (ABI), carotid intima-media thickness (CMT), carotid plaque, estimated glomerular filtration rate (eGFR) and the urine albumin-to-creatinine ratio (UACR), were measured and calculated. Results: In univariate logistic regression, an increased TyG index was associated with a higher risk of cf-PWV > 10 m/s, ba-PWV > 1800 cm/s, ABI < 0.9, microalbuminuria (MAU) and chronic kidney disease (CKD). In multivariable logistic regression, there was a significant increase in the risk of cf-PWV > 10 m/s (OR = 1.86, 95% confidence interval [95% CI] 1.37-2.53, P for trend < 0.001), ba-PWV > 1800 cm/s (OR = 1.39, [95% CI] 1.05-1.84, P for trend = 0.02), MAU (OR = 1.61, [95% CI] 1.22-2.13, P for trend < 0.001) and CKD (OR = 1.67, [95% CI] 1.10-1.50, P for trend = 0.02) after adjustment for age, sex, BMI, waist circumference, smoking habit, hypertension, family history of premature CVD, diabetes, HDL-C, LDL-C, insulin therapy and statin therapy. However, no significant relationship was observed between the TyG index and lower extremity atherosclerosis, carotid hypertrophy or carotid plaque. Conclusion: An elevated TyG index was significantly associated with a higher risk of arterial stiffness and nephric microvascular damage. This conclusion lends support to the clinical significance of the TyG index for the assessment of vascular damage.

show abstract

Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Association between macro- and microvascular damage and the triglyceride glucose index in community-dwelling elderly individuals: the Northern Shanghai Study

Zhao

Chen

et al. 2019

Cardiovasc Diabetol

189

194

View full text Add to dashboard Cite

show abstract

“…Indeed, experimental studies have shown that remnant lipoproteins can enter the intima of the arterial wall and be taken up by macrophages to induce foam cell formation (8). Several observational clinical studies, including ours, associated high RC concentrations with increased risk for CAD (4,9). Furthermore, evidence from Mendelian randomization studies indicated a causal association of RC with CAD development in previously healthy individuals (10,11).…”

mentioning

confidence: 70%

Prognostic utility of triglyceride-rich lipoprotein-related markers in patients with coronary artery disease

Cao

Zhang

Jin

et al. 2020

Journal of Lipid Research

Self Cite

View full text Add to dashboard Cite

Triglyceride-rich lipoproteins (TRL)-related biomarkers, including TRL-cholesterol (TRL-C), remnant-like lipoprotein particles cholesterol (RLP-C) and apolipoprotein C-III (apoC-III), have been associated with atherosclerosis. However, their prognostic values have not been fully determined, especially in patients with previous coronary artery disease (CAD). This study aimed to examine the associations of TRL-C, RLP-C and apoC-III with incident cardiovascular events (CVEs) in the setting of secondary prevention of CAD. Plasma TRL-C, RLP-C and total apoC-III were directly measured. A total of 4355 participants with angiographically confirmed CAD were followed-up for the occurrence of CVEs. During a median follow-up period of 5.1 (IQR: 3.9-6.4) years, 543 (12.5%) events occurred. Patients with incident CVEs had significantly higher levels of TRL-C, RLP-C and apoC-III than those without events. Multivariable Cox analysis indicated that a log unit increase in TRL-C, RLP-C and apoC-III increased the risk of CVEs by 49% (95%CI: 1.16-1.93), 21% (95%CI: 1.09-1.35) and 40% (95%CI: 1.11-1.77), respectively. High TRL-C, RLP-C and apoC-III were also independent predictors of CVEs in individuals with low-density lipoprotein cholesterol levels ≤1.8 mmol/L (n=1068). The addition of RLP-C level to a prediction model resulted in a significant increase in discrimination and all three TRL biomarkers improved risk reclassification. Thus, TRL-C, RLP-C, and apoC-III levels were independently associated with incident CVEs in Chinese CAD patients undergoing statin therapy.

show abstract

“…As we know, there are few studies about using nonfasting lipids to evaluate cardiovascular risk for primary prevention in China (17), especially in comparison between fasting and non-fasting lipids in the same patients on the same day (18). The aim of this study was to use fasting and non-fasting lipid profiles to estimate CVD risk in Chinese participants through two established risk assessment tools: China atherosclerotic CVD (ASCVD) risk estimator and Europe Systemic Coronary Risk Estimation (SCORE) risk charts, and compare the consistency between two estimators.…”

Section: Introductionmentioning

confidence: 99%

Non-fasting lipid profile for cardiovascular risk assessments using China ASCVD risk estimator and Europe SCORE risk charts in Chinese participants

Zhang¹,

Du²,

Xu³

et al. 2021

Cardiovasc Diagn Ther

View full text Add to dashboard Cite

Background: Previous studies have shown that non-fasting lipids have similar values in cardiovascular risk estimation as fasting, but it is not clear whether this could also be applicable to Chinese participants.Methods: A total of 127 (76 men, 51 women) participants without atherosclerotic cardiovascular diseases (ASCVD) were enrolled in the study. Serum levels of blood lipids were monitored at 0 h, 2 h and 4 h after a daily breakfast. Ten-year cardiovascular disease (CVD) risk was estimated with China ASCVD risk estimator and European SCORE risk charts. Kappa statistic was used to determine agreement among estimators.Results: China ASCVD risk estimator assessed half of the participants as low risk, while European risk charts assessed half of the participants as moderate risk in the same participants. Reliability analysis in China ASCVD risk estimator and Europe SCORE risk charts based on fasting and or non-fasting lipids profile were relatively high (Kappa =0.731 or 0.718, P<0.001), (Kappa =0.922 or 0.935, P<0.001) (Kappa =0.886 or 0.874, P<0.001), but agreement between two were relatively poor in both fasting and non-fasting states (Kappa =0.339 or 0.300, P<0.001), (Kappa =0.364 or 0.286, P<0.001).Conclusions: Promoting use of non-fasting lipids in diagnosis, evaluation, and prediction of CVD are feasible. Furthermore, non-fasting lipids could be used in China ASCVD risk estimator to evaluate 10-year risk of ASCVD among Chinese general participants.

show abstract

Predictive value of non-fasting remnant cholesterol for short-term outcome of diabetics with new-onset stable coronary artery disease

Cited by 28 publications

References 36 publications

Association between macro- and microvascular damage and the triglyceride glucose index in community-dwelling elderly individuals: the Northern Shanghai Study

Association between macro- and microvascular damage and the triglyceride glucose index in community-dwelling elderly individuals: the Northern Shanghai Study

Prognostic utility of triglyceride-rich lipoprotein-related markers in patients with coronary artery disease

Non-fasting lipid profile for cardiovascular risk assessments using China ASCVD risk estimator and Europe SCORE risk charts in Chinese participants

Contact Info

Product

Resources

About