Non-fasting lipid profile for cardiovascular risk assessments using China ASCVD risk estimator and Europe SCORE risk charts in Chinese participants

Zhang, Shi-Lan; Du, Xiao; Xu, Jin; Xiang, Qunyan; Liu, Ling

doi:10.21037/cdt-20-1012

Cited by 3 publications

(3 citation statements)

References 47 publications

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“…Varios estudios y registros poblacionales a gran escala, que incluyen niños, mujeres, hombres y pacientes con diabetes, han establecido que los lípidos plasmáticos y las lipoproteínas cambian solo modestamente en respuesta a la ingesta habitual de alimentos 30 . Las concentraciones de lípidos en periodos de no ayuna predicen un aumento del riesgo cardiovascular 31 . La mayoría de las personas comen regularmente durante el día y por lo general solo ayunan en la noche (definido como un tiempo menor de 8 horas desde la última comida), por lo que se ha planteado que una prueba de tolerancia de grasa oral es mejor para establecer las concentraciones de lípidos postprandiales 25 .…”

Section: Discussionunclassified

Trigliceridos mayores a 100mg/dl en relación a valores postprandiales, HOMA, No- HDL y Colesterol Remanente

Obregón,

Aure,

Lares Amaiz

et al. 2024

Rev Cien CMDLT

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Triglicéridos en ayunas >100 mg / dl se encuentran asociados con Resistencia a la Insulina y dislipidemia aterogenica Objetivo: evaluar el aumento de triglicéridos postprandiales tomando como base triglicéridos en ayuna con valores mayores y menores de 100 mg|dL , en pacientes despues de su desayuno habitual y correlacionarlos con Resistencia a la insulina medida por HOMA y Colesterol y sus fracciones asi como Colesterol No HDL y Colesterol Remanente Método: Estudio descriptivo de corte transversal, con una población de pacientes de la consulta de Endocrinología del Hospital Militar Dr. Carlos Arvelo de Caracas. Las muestras fueron tomadas en ayuna y a las 2 horas depués de una comida, y se dividieron los pacientes en 2 grupos según trigliceridos mayores o menores de 100mg/dl Resultados: Los pacientes con trigliceridos menores de 100mg/dl presentaron triglicéridos a las 2 horas menores a 150mg/dl, en los dos grupos los triglicéridos subieron en promedio 49 mg/dl. El colesterol no HDL, el colesterol remanente y el HOMA estaban más alto estadísticamente significativos en los pacientes con triglicéridos basales mayores a 100 mg/dl así como el HDL colesterol era menor en pacientes. Conclusiones: en nuestro estudio los triglicéridos por debajo de 100mg/dl se acompañaban de HDL colesterol alto mientras los valores de triglicéridos por encima de 100m/dl se acompañaban de HDL colesterol bajo, mayor HOMA, mayor colesterol remanente y mayor colesterol No HDL

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Section: Discussionunclassified

Trigliceridos mayores a 100mg/dl en relación a valores postprandiales, HOMA, No- HDL y Colesterol Remanente

Obregón,

Aure,

Lares Amaiz

et al. 2024

Rev Cien CMDLT

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“…It is worth noting that measurement of either a fasting or non-fasting lipid profile is effective in estimating cardiovascular risk ( 39 ) and for documenting a baseline LDL-C level to evaluate cholesterol control in patients with CHD ( 40 ). In other words, the non-fasting reduction in LDL-C level either obvious or not in Chinese subjects should not be a factor interfering with the application of non-fasting blood lipid detection in clinical practice.…”

Section: Discussionmentioning

confidence: 99%

Non-fasting Changes in Blood Lipids After Three Daily Meals Within a Day in Chinese Inpatients With Cardiovascular Diseases

Tan

Lin

et al. 2022

Front. Cardiovasc. Med.

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BackgroundNon-fasting (i.e., postprandial) lipid detection is recommended in clinical practice. However, the change in blood lipids in Chinese patients with cardiovascular diseases after three daily meals has never been reported yet.MethodsSerum levels of blood lipids were measured or calculated in 77 inpatients (48 men and 29 women) at high or very high risk of atherosclerotic cardiovascular disease (ASCVD) in the fasting state and at 4 h after three meals within a day according to their diet habits.ResultsFemale patients showed significantly higher level of high-density lipoprotein cholesterol (HDL-C) than male patients, and the gender difference in other lipid parameters did not reach statistical significance at any time-point. Levels of triglyceride (TG) and remnant cholesterol (RC) increased, while that of low-density lipoprotein cholesterol (LDL-C) decreased significantly after three meals (p < 0.05). Levels of HDL-C, total cholesterol (TC), and non-high-density lipoprotein cholesterol (non-HDL-C) showed smaller changes after three meals. Percent reductions in the non-fasting LDL-C levels after lunch and supper were around 20%, which were greater than that after breakfast. The percent reductions in the non-fasting non-HDL-C levels after three meals were smaller than those in the non-fasting LDL-C levels. Patients with TG level ≥ 2.0 mmol/L (177 mg/dL) after lunch had significantly greater absolute reduction of LDL-C level than those with TG level < 2.0 mmol/L (177 mg/dL) after lunch [–0.69 mmol/L (–27 mg/dL) vs. –0.36 mmol/L (–14 mg/dL), p<0.01]. There was a significant and negative correlation between absolute change in LDL-C level and that in TG level (r = −0.32) or RC level (r = −0.67) after lunch (both p<0.01).ConclusionLDL-C level decreased significantly after three daily meals in Chinese patients at high or very high risk of ASCVD, especially when TG level reached its peak after lunch. Relatively, non-HDL-C level was more stable than LDL-C level postprandially. Therefore, when LDL-C level was measured in the non-fasting state, non-HDL-C level could be evaluated simultaneously to reduce the interference of related factors, such as postprandial hypertriglyceridemia, on detection.

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“…Non-fasting serum TC and TG levels were measured using a Beckman Coulter Kit (Beckman Coulter, Inc., CA, USA) since previous studies showed no significant differences between lipid profiles obtained with fasting and non-fasting blood samples. 26 - 30 …”

Section: Methodsmentioning

confidence: 99%

Genetic Association Between Polycystic Ovary Syndrome and the APOA5 rs662799 and PLIN1 rs894160 Metabolic Variants in the Western Saudi Population: A Case-Control Study

Bakhashab,

Batarfi,

Alhartani

et al. 2024

Biomark�Insights

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Background: Polycystic ovary syndrome (PCOS) is a common endocrinological condition affecting women of reproductive age, associated with insulin resistance and obesity. PCOS pathogenesis is complex and multifactorial, involving genetic and environmental factors. Objectives: This study aimed to determine and compare genotype and allele frequencies of single nucleotide polymorphisms (SNPs) in the apolipoprotein A5 ( APOA5; rs662799) and perilipin 1 ( PLIN1; rs894160, rs1052700 and rs6496589) genes in Western Saudi women to investigate their association with PCOS and its clinical characteristics. Design and methods: This was a case-control study conducted on women with ( n = 104) and without ( n = 87) PCOS. The SNPs were genotyped using TaqMan genotyping assays. Results: Significant and direct associations were detected between PCOS susceptibility and APOA5 SNP rs662799 and PLIN1 SNP rs894160 ( P < .001). For APOA5 SNP rs662799, women with the A allele were more likely to have PCOS (relative risk [RR] = 1.348, odds ratio [OR] = 2.313, P < .001) and hypertriglyceridaemia (OR = 17.0, P = .5) than women with the G allele. For PLIN1 SNP rs894160, women with the T allele were more likely to have PCOS than women with the C allele (RR = 8.043, OR = 7.427, P < .001). For PLIN1 SNP rs1052700, women with the TT genotype were more likely to have hyperandrogenism (OR = 29.75, P = .02) and an irregular period (OR = 0.07, P = .040) than women with the AT genotype. Conclusion: We identified novel alleles and genotypes contributing to the genetic risk of PCOS in the Western Saudi population.

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Non-fasting lipid profile for cardiovascular risk assessments using China ASCVD risk estimator and Europe SCORE risk charts in Chinese participants

Cited by 3 publications

References 47 publications

Trigliceridos mayores a 100mg/dl en relación a valores postprandiales, HOMA, No- HDL y Colesterol Remanente

Trigliceridos mayores a 100mg/dl en relación a valores postprandiales, HOMA, No- HDL y Colesterol Remanente

Non-fasting Changes in Blood Lipids After Three Daily Meals Within a Day in Chinese Inpatients With Cardiovascular Diseases

Genetic Association Between Polycystic Ovary Syndrome and the APOA5 rs662799 and PLIN1 rs894160 Metabolic Variants in the Western Saudi Population: A Case-Control Study

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