Role of Reactive Oxygen Species and Bcl-2 Family Proteins in TNF-α-Induced Apoptosis of Lymphocytes

Ryazanceva, N. V.; Novickiy, V. V.; Жукова, О. Б.; Biktasova, Asel; Чечина, О. Е.; Sazonova, Elena V.; Belkina, M. V.; Chasovskih, N. Yu.; Хаитова, З. К.

doi:10.1007/s10517-010-0902-7

Cited by 3 publications

(1 citation statement)

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“…It is unclear whether plasma can induce regulatory T-cells and influence thereby T-cell mediated autoimmune diseases, however, it does reduce T-cell number similarly as observed after UVB irradiation (Kohlhardt-Floehr et al 2010). On the other hand, an increase in intracellular reactive oxygen species, which can also be generated by plasma, induces apoptosis in lymphocytes (Ryazanceva et al 2010). Hydrogen peroxide has been shown to decrease T H1 cells with no change of T H2 cells .…”

Section: Resultsmentioning

confidence: 99%

Differential sensitivity of lymphocyte subpopulations to non-thermal atmospheric-pressure plasma

et al. 2012

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Section: Resultsmentioning

confidence: 99%

Differential sensitivity of lymphocyte subpopulations to non-thermal atmospheric-pressure plasma

et al. 2012

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Effect of Galectin-1 on Apoptosis of CD4+ Lymphocytes Differentiated In Vitro Towards Regulatory T Cells

et al. 2014

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We studied the effect of galectin-1 on apoptosis of CD4(+) lymphocytes intact and in vitro differentiated towards regulatory T cells. An increase in the content of apoptotic CD4(+) lymphocytes was observed after exposure of intact cells with 15 ng/ml galectin-1 and after exposure of regulatory T cells with 10 and 15 ng/ml galectin-1. Apoptosis of regulatory T cells induced by galectin-1 was accompanied by an increase in the content of proapoptotic protein Bad.

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Synthesized glucocorticoid‐induced leucine zipper peptide inhibits photoreceptor apoptosis and protects retinal function in light‐induced retinal degeneration model

Tang

Lei

et al. 2019

Clinical Exper Ophthalmology

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BackgroundThis study aimed to investigate the neuroprotective function of a synthesized glucocorticoid‐induced leucine zipper peptide (GILZ‐p) in a light‐induced retinal degeneration model.MethodsThe GILZ98‐134 peptide was synthesized and injected intravitreally into Sprague Dawley rats. Retinal injury was then induced in the rats by exposing their eyes to constant white light (5000 lux) for 24 h. The activation of retinal caspases‐9/3 and the release of cytochrome c from the mitochondria to the cytosol were measured at 1, 3, 5 and 7 d after light injury. Photoreceptor apoptosis was evaluated with terminal‐deoxynucleotidyl‐transferase‐mediated deoxyuridine triphosphate‐biotin nick end labelling (TUNEL) staining at 3 d after injury. Haematoxylin and eosin staining and electroretinography were used to observe the changes in the retinal morphology and function, respectively, at 7 and 14 d after light injury.ResultsThe intravitreally injected synthesized GILZ‐p successfully penetrated to the retina and significantly inhibited the activation of retinal caspase‐3 and caspase‐9 at 1, 3, 5 and 7 d after light injury, and reduced the number of TUNEL‐positive photoreceptors at 3 d after light injury. GILZ‐p pre‐treatment also alleviated cytochrome c release and rescued mitochondria‐mediated apoptosis after injury. Simultaneously, GILZ‐p pre‐treatment also mitigated the light‐induced thinning of the outer nuclear layer and the loss of retinal function at 7 and 14 d after light injury, respectively.ConclusionsThe synthesized GILZ‐p prevented light‐induced photoreceptor apoptosis and protected retinal function from degeneration, and is therefore a potential therapeutic option for degenerative retinal diseases.

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Role of Reactive Oxygen Species and Bcl-2 Family Proteins in TNF-α-Induced Apoptosis of Lymphocytes

Cited by 3 publications

References 10 publications

Differential sensitivity of lymphocyte subpopulations to non-thermal atmospheric-pressure plasma

Differential sensitivity of lymphocyte subpopulations to non-thermal atmospheric-pressure plasma

Effect of Galectin-1 on Apoptosis of CD4+ Lymphocytes Differentiated In Vitro Towards Regulatory T Cells

Synthesized glucocorticoid‐induced leucine zipper peptide inhibits photoreceptor apoptosis and protects retinal function in light‐induced retinal degeneration model

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