Role of rapid on-site evaluation in CT-guided fine needle aspiration cytology of lung nodules

Anila, KR; Nayak, Nileena; Venugopal, M; Jayasree, K

doi:10.4103/joc.joc_134_17

Cited by 19 publications

(28 citation statements)

References 10 publications

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“…Unfortunately, few studies have focused on the diagnostic accuracy of ROSE by comparing it with histopathology. Consistent with a study by Anila et al, 14 we found that ROSE had excellent efficacy in determining adequacy of specimens. In three cases, ROSE resulted in a false negative result of inadequacy and these cases were diagnosed as adenocarcinoma, primary tracheal leiomyoma, and atypical cells by histopathology.…”

Section: Discussionsupporting

confidence: 92%

“…This patient was finally diagnosed with adenocarcinoma after surgery. A similar situation was previously reported, 14 and there was speculation that a difficult biopsy or intolerance of the patient caused few specimens to be obtained. Additionally, fragmentation of specimens into pieces and diagnostic material with a different distribution might have caused this situation.…”

Section: Discussionsupporting

confidence: 78%

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Efficacy of rapid on-site cytological evaluation (ROSE) by a pulmonologist in determining specimen adequacy and diagnostic accuracy in interventional diagnosis of lung lesions

et al. 2021

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Objective To evaluate the efficacy of rapid on-site cytological evaluation (ROSE) in determining specimen adequacy and diagnostic accuracy in the interventional diagnosis of lung lesions. Methods This retrospective study included 127 consecutive cases of lung lesions, which were sampled by bronchoscopy or transthoracic fine needle aspiration, and diagnosed on ROSE followed by histopathology. ROSE was performed by a trained pulmonologist and the diagnosis of ROSE was compared with the final diagnosis. Results The sensitivity of ROSE in determining adequacy of specimens was 97.5% and specificity in determining inadequacy was 85.7%. The diagnostic efficacy of ROSE for assessing malignancy (sensitivity of 94.5% and specificity of 100%) and non-malignancy (sensitivity of 97.8% and specificity of 100%) was excellent. The sensitivity of ROSE for diagnosing small cell carcinoma (100%) was highest, followed by adenocarcinoma (89.2%) and squamous cell carcinoma (75.0%). Performance of ROSE by a trained pulmonologist also determined tuberculosis with a high diagnostic sensitivity (83.3%) and specificity (100%). Conclusions A trained pulmonologist can reliably carry out ROSE to ensure the adequacy of the sample, distinguish between malignancy and non-malignancy, and make a preliminary diagnosis in a large number of cases.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 78%

Efficacy of rapid on-site cytological evaluation (ROSE) by a pulmonologist in determining specimen adequacy and diagnostic accuracy in interventional diagnosis of lung lesions

et al. 2021

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“…While obtaining specimens, we reduced the times of punctures as much as possible. Ten patients underwent CT-guided lung biopsy, as ROSE was performed during the puncture process to increase the positive rate of specimens (17)(18)(19)(20)(21).…”

Section: Discussionmentioning

confidence: 99%

Real-time and accuracy of rapid on-site cytological evaluation of lung cancer

Huang¹,

Zhuang²,

Feng³

et al. 2021

Transl Cancer Res TCR

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Background: Although using pathological diagnosis is the gold standard for lung cancer diagnosis, pathological reports take a long time. Rapid on-site assessment (ROSE) is a method to determine whether the quality of the specimens is sufficient for cytopathological diagnosis, which issues a preliminary report during the operation and takes shorter time. The aim of this study is to explore the clinical significance of rapid on-site evaluation (ROSE) in the diagnosis of lung cancer in terms of real-time and accuracy. Methods: A total of 38 suspected lung cancer cases were enrolled from August 2019 to July 2020. Patients received ROSE and pathological examinations at the same time. The coincidence rate of the two diagnostic approaches was calculated, and statistical analysis was carried out to evaluate whether the time difference between the ROSE report and the pathological report reached statistical significance. Results: A total of 38 suspected lung cancer cases were enrolled from August 2019 to July 2020. Patients received ROSE and pathological examinations at the same time. The coincidence rate of the two diagnostic approaches was calculated, and statistical analysis was carried out to evaluate whether the time difference between the ROSE report and the pathological report reached statistical significance.. Conclusions: ROSE has the advantage of rapid and accurate diagnosis for lung cancer, and has great clinical significance.

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“…On-site cytology evaluation has shown to improve a diagnostic accuracy and reduce needle passes in image-guided transthoracic needle aspiration. 29,30 It is not clear whether additional diagnostic gain could be obtained when a core biopsy needle is used. However, in the case of FNA, the combination with ROSE provides a comparable diagnostic accuracy to that of a core needle biopsy for malignant lesions.…”

Section: Rapid On-site Evaluation (Rose)mentioning

confidence: 99%

“…On-site cytology evaluation has shown to improve a diagnostic accuracy and reduce needle passes in image-guided transthoracic needle aspiration [ 27 , 28 ]. It is not clear whether additional diagnostic gain could be obtained when a core biopsy needle is used.…”

Section: How To Maximize Diagnostic Accuracymentioning

confidence: 99%

Transthoracic Needle Biopsy: How to Maximize Diagnostic Accuracy and Minimize Complications

2020

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While the transthoracic needle biopsy (TTNB) was introduced for lung biopsy about 40 years ago, it is still mainstay of pathologic diagnosis in lung cancer, because it is relatively inexpensive and has the advantage of obtaining tissue regardless of tumorbronchus relationship. With several technological advances, clinicians can perform TTNB more safely and accurately. Utilizing ultrasound-guided biopsy for peripheral lesions contacting the pleura and rapid on-site evaluation during the procedure are expected to make up the weakness of TTNB. However, due to the inherent limitations of the percutaneous approach, the incidence of complications such as pneumothorax or bleeding are inevitably higher than those of other lung biopsy techniques. Selecting an appropriate guidance modality and optimal instruments could decrease the complication rate. Thorough understating and reflection of each biopsy modality with elaborate technique are fundamental for maximizing diagnostic accuracy and minimizing the complications.

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Role of rapid on-site evaluation in CT-guided fine needle aspiration cytology of lung nodules

Cited by 19 publications

References 10 publications

Efficacy of rapid on-site cytological evaluation (ROSE) by a pulmonologist in determining specimen adequacy and diagnostic accuracy in interventional diagnosis of lung lesions

Efficacy of rapid on-site cytological evaluation (ROSE) by a pulmonologist in determining specimen adequacy and diagnostic accuracy in interventional diagnosis of lung lesions

Real-time and accuracy of rapid on-site cytological evaluation of lung cancer

Transthoracic Needle Biopsy: How to Maximize Diagnostic Accuracy and Minimize Complications

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