Real-time and accuracy of rapid on-site cytological evaluation of lung cancer

Abstract

Background: Although using pathological diagnosis is the gold standard for lung cancer diagnosis, pathological reports take a long time. Rapid on-site assessment (ROSE) is a method to determine whether the quality of the specimens is sufficient for cytopathological diagnosis, which issues a preliminary report during the operation and takes shorter time. The aim of this study is to explore the clinical significance of rapid on-site evaluation (ROSE) in the diagnosis of lung cancer in terms of real-time and accuracy. Methods: A total of 38 suspected lung cancer cases were enrolled from August 2019 to July 2020. Patients received ROSE and pathological examinations at the same time. The coincidence rate of the two diagnostic approaches was calculated, and statistical analysis was carried out to evaluate whether the time difference between the ROSE report and the pathological report reached statistical significance. Results: A total of 38 suspected lung cancer cases were enrolled from August 2019 to July 2020. Patients received ROSE and pathological examinations at the same time. The coincidence rate of the two diagnostic approaches was calculated, and statistical analysis was carried out to evaluate whether the time difference between the ROSE report and the pathological report reached statistical significance.. Conclusions: ROSE has the advantage of rapid and accurate diagnosis for lung cancer, and has great clinical significance.

Validation of a Cytological Classification System for the Rapid On-Site Evaluation (Rose) of Pulmonary and Mediastinal Needle Aspirates

“…ROSE is a widely used and effective diagnostic procedure during a needle aspiration biopsy of different organs [ 19 , 20 , 21 , 22 , 23 , 24 , 25 ]. In the field of thoracic pathologies, several studies have demonstrated the utility of ROSE during both transbronchial and percutaneous needle aspiration techniques [ 1 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 ]. Even if some works failed to demonstrate that ROSE increases the sensitivity during cTBNA or EBUS-TBNA [ 15 , 16 ], there is robust evidence that ROSE may significantly reduce the need for additional passes and the complication rate, most importantly improving the adequacy of the samples addressed to molecular chacaterization of mandatory predictive biomarkers in non-small cell lung cancer [ 6 , 17 , 26 ].…”

“…ROSE may be performed during a cytology biopsy from any anatomic site. In the field of respiratory medicine, ROSE is commonly used during bronchoscopic sampling techniques (transbronchial fine needle aspiration, TBNA) or transthoracic fine needle aspiration (TTNA) of lung and/or mediastinum [ 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 ].…”

Computed tomography-guided lung biopsy with rapid on-site evaluation for diagnosis of lung lesions: a meta-analysis

“…Rapid on-site evaluation (ROSE) offers an approach to rapidly conduct cytomorphological characteristics of tissues obtained from biopsy procedures in order to gauge their adequacy and malignancy. ROSE procedures performed by experienced pathologists can contribute to improved LB diagnostic accuracy [ 10 ]. ROSE techniques have been frequently employed in the context of bronchoscopy-guided biopsy procedures [ 10 – 15 ].…”

“…ROSE procedures performed by experienced pathologists can contribute to improved LB diagnostic accuracy [ 10 ]. ROSE techniques have been frequently employed in the context of bronchoscopy-guided biopsy procedures [ 10 – 15 ]. In contrast, there have been fewer studies regarding the application of ROSE approaches in the context of CT-guided LB [ 16 – 22 ].…”