Role of Quercetin Benefits in Neurodegeneration

Abstract

Neurodegenerative disorders are often life threatening and hired as an economic burden to the health-care system. Nutritional interventions principally involving polyphenols were practiced to arrest or reverse the age-related health disorders. Flavonoids, a class of dietary polyphenols, are rising to superstardom in preventing brain disorders with their potent antioxidant defense mechanism. Quercetin is a ubiquitous flavonoid reported to have all-natural myriad of health benefits. Citrus fruits, apple, onion, parsley, berries, green tea, and red wine comprise the major dietary supplements of quercetin apart from some herbal remedies like Ginkgo biloba. Appositeness of quercetin in reducing risks of neurodegenerative disorders, cancer, cardiovascular diseases, allergic disorders, thrombosis, atherosclerosis, hypertension, and arrhythmia, to name a few, is attributed to its highly pronounced antioxidant and anti-inflammatory properties. Neurodegeneration, characterized by progressive deterioration of the structure and function of neurons, is crucially accompanied by severe cognitive deficits. Aging is the major risk factor for neurodegenerative disorders in Alzheimer's disease (AD), Parkinson's disease (PD), and Huntington's disease (HD) being coequal high hands. Oxidative stress and mitochondrial dysfunction are the key players in triggering neurodegeneration. The upsurge of neurodegenerative disorders is always appalling since there exists a paucity in effective treatment practices. Past few years' studies have underpinned the mechanisms through which quercetin boons the brain health in many aspects including betterment in cognitive output. Undoubtedly, quercetin will be escalating as an arable field, both in scientific research and in pharmacological and clinical applications.

Geroprotective and Radioprotective Activity of Quercetin, (-)-Epicatechin, and Ibuprofen in Drosophila melanogaster

“…Firstly, well-known anti-oxidant properties of quercetin and (-)-epicatechin provide the protection of cellular macromolecules from damages and predict the mitochondrial dysfunction (Khan et al, 2016). In this way, studied drugs demonstrated benefit action against the development of aging-related pathologies including neurodegeneration (Shay et al, 2015; Barreca et al, 2016; Elumalai and Lakshmi, 2016), cardiovascular and liver diseases (Ansar et al, 2016; Cheserek et al, 2016), diabetes (Shay et al, 2015; Haddad and Eid, 2016), cancer (Shay et al, 2015; Khan et al, 2016). …”

Antitumor Effects of Quercetin in Hepatocarcinoma In Vitro and In Vivo Models: A Systematic Review

“…This flavonoid has many beneficial properties on human health [2], being associated its biological activity with the presence of five hydroxyl groups on the ring structure [1]. A number of studies have investigated quercetin effects on cellular processes involved in different human pathologies [3,4]. Anti-inflammatory, antioxidant and anticancer activities are some of the mainly described quercetin mechanisms of action [1,2,5].…”

“…Anti-inflammatory, antioxidant and anticancer activities are some of the mainly described quercetin mechanisms of action [1,2,5]. Besides, therapeutic potential of this flavonoid has been evaluated in a broad variety of human disorders, including diabetes [3], cardiovascular [3], neurodegenerative [3,4,6] and Alzheimer's diseases [6]; and positive actions on blood vessel pressure, intestinal microbiota and kidney disfunction [5], among others, were also related to quercetin efficacy.…”

Can Medicinal Plants and Bioactive Compounds Combat Lipid Peroxidation Product 4-HNE-Induced Deleterious Effects?

“…This extract inhibits 4-HNE-induced cleavage of PARP and protects against apoptosis in neuronal-like catecholaminergic cells (rat pheochromocytoma, PC12 cells) by reducing intracellular ROS [19]. Polyphenolic flavonoids quercetin and myricetin isolated from red wine extract or Ginkgo biloba extract have cytoprotective effects on 4-HNE-induced PC12 cell death [19], further demonstrating the benefits in neurodegeneration [20,21]. Other medicinal plant flavonoids luteolin and apigenin have antioxidant, anti-inflammatory, and neuroprotective effects.…”