Role of Propolis in Osteointegration Enhancement in Allograft Autoclaved Implanted in Femur of Dogs

Management of Class II furcation defects in dogs using combination of Propolis and Nanobone graft

“…New bone formation was more pronounced in propolis & propolis/nanobone group as confirmed by histologic and histomorphometric analysis. Similar to our findings, Boudra et al 20 showed that propolis enhanced the regenerative potential of allograft leading to better bone formation. Additionally, previous study 16 showed that when combining alveolex (containing 10% propolis) with rhBMP-2 improvement in bone regeneration was observed in calvarial defects.…”

“…Regarding the percentage of the newly formed bone in the current work, all groups showed similar bone fill after 1 month, however, the propolis group showed more bone fill after three months. Boudra et al 20 showed that the use of graft material covered with propolis accelerate the osteoconductive and osteoinductive process. This is similar to our findings that the combination of nanobone with propolis showed more bone formation than using nanobone alone.…”

Egyptian propolis compared to nanohydroxyapatite graft in the treatment of Class II furcation defects in dogs

“…In the collagen/propolis group, the noticeable ingrowth of bone and the high activity of osteoblasts revealed in the histological results, reflect the high bone regenerative ability and the osseoconductive and osseoinductive potential of propolis. This was also revealed in a study by Boudra et al . in which allografts covered by a thin layer of propolis were used in the management of fractured dog's femur.…”

“…Propolis or bee glue, is a sticky complex resinous material made by the Apis mellifera honeybees and is proven to have bone regenerative effects . Propolis has been found to have versatile biological activities.…”

Evaluation of the Effect of Propolis on Implant Stability by Resonance Frequency Analysis and Removal Torque Test

“…In a rabbit study, the intraarticular administration of propolis in the experimental septic arthritis model yielded beneficial results [29]. Another study showed that a layer of propolis application with allograft enhanced and accelerated osseointegration and shortened the consolidation phase [30]. In addition, the ability to obtain a dense form of propolis that is homogeneously dissolved, has no toxic effect and can be easily applied to the implant cavity, allowed us to plan the study in this way.…”