Egyptian propolis compared to nanohydroxyapatite graft in the treatment of Class II furcation defects in dogs

Zohery, Amr A.; Meshri, Suzanne M.; Madi, Marwa; Rehim, Samia S. Abd El; Nour, Zubaida M.

doi:10.1002/jper.17-0685

Cited by 17 publications

(22 citation statements)

References 44 publications

(52 reference statements)

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“…As reported by Zoheri el al. 13 it is of great interest to report similar regenerative potential of propolis being a natural product, cheap and readily available-to that obtained by nanohydroxyapatite graft material.…”

Section: Introductionmentioning

confidence: 94%

“…In a novel study in 2018 Zohery et al 13 examined the use of propolis as bone graft substitute in experimental grade II furcation defects and obtained favorable results regarding periodontal regeneration comparable to that obtained by nanohydroxyapatite graft. Nanohydroxyapatite graft materials are nanosized ceramics with better osseointegrative properties and quick resorbtion 14,15 .…”

Section: Introductionmentioning

confidence: 99%

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Management of Class II furcation defects in dogs using combination of Propolis and Nanobone graft

Khalil

Fahmy

2019

Egyptian Dental Journal

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Background: Periodontal regeneration using complementary and alternative medicine has gained considerable attention recently. Propolis is a resinous hive product collected by honey bees from exudates and buds of plants and mixed with wax and bee enzymes.Objective: The aim of this study was to evaluate the effect of propolis as bone graft substitute in the management of experimental grade II furcation defects, and to compare its effect to nanobone and to Propolis/nanobone mixture. Material and Methods:Sixteen critical-sized furcation defects on the buccal surface of mandibular third and fourth premolars were surgically created in twelve dogs and divided into three groups. Group I; defects were filled with Propolis, Group II; defects were filled with nanohydroxyapatite graft and Group III; defects were filled with a combination of Propolis/ nanohydroxyapatite graft. Histologically and histomorphometric analysis of newly formed interradicular bone height and percentage were performed after one and three months.Results: After one month; the three experimental groups revealed the features of early periodontal tissues regeneration including cementum, newly formed bone with inserted newly formed PDL fibers. The propolis group showed the highest bone height and bone surface area. After three months; denser bone occupying larger surface area of the furcation defect were noted especially in the propolis group. Conclusion:The addition of nanobone to propolis showed better results than nano bone alone especially at early healing stage. However, it didn't show better results than the use of propolis alone.

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Section: Introductionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Management of Class II furcation defects in dogs using combination of Propolis and Nanobone graft

Khalil

Fahmy

2019

Egyptian Dental Journal

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“…The bone healing properties of propolis were explored using critical non-union bone defects in Wistar rats (dose of propolis: 0.1 mL of 250 mg/mL propolis percutaneously with chitosan or bone graft) [44], femur fracture in Sprague Dawley rats (implanted with 60% propolis loaded implants and treated with 200 mg/kg of propolis) [45], distraction osteogenesis in New Zealand white rabbits (dose of propolis: 100 and 200 mg/kg) [46]. For the periodontal models, periodontitis-induced bone loss in Wistar rats and C57BL/6 mice (dose of propolis: 100-200 mg/kg) [47][48][49], orthodontic tooth movement (OTM) in Wistar rats and guinea pigs (dose of propolis: 2-5% and 100 µL of propolis) [50][51][52]; delayed tooth replantation in Wistar rats (dose of propolis: 200 mL of 15% propolis solution) [53], rapid maxillary expansion (RME) in Wistar rats (dose of propolis: 100 mg/kg or propolis) [54]; grade II furcation-induced bone loss in mongrel dogs (dose of propolis: 400 mg in graft) [55] were studied. In animal studies, densitometry method was used to measure bone mass, micro-computed tomography and bone histomorphometry were used to determine bone microstructure, and circulating bone markers were used to estimate the bone remodelling.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Two studies showed that propolis promoted fracture healing of the femur [45] and non-union defect of the radial bone [44]. Three studies demonstrated no beneficial effects of propolis on inflammatory resorption, replacement resorption and extent of fusion between alveolar bone and cementum in delayed tooth replantation [53]; new bone formation in grade II furcation defect [55]; and alveolar bone loss [47]. Table 1 summarises the effects of propolis on the bone health system.…”

Section: Study Characteristicsmentioning

confidence: 99%

Application of Propolis in Protecting Skeletal and Periodontal Health—A Systematic Review

Ekeuku

Chin

2021

Molecules

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Chronic inflammation and oxidative stress are two major mechanisms leading to the imbalance between bone resorption and bone formation rate, and subsequently, bone loss. Thus, functional foods and dietary compounds with antioxidant and anti-inflammatory could protect skeletal health. This review aims to examine the current evidence on the skeletal protective effects of propolis, a resin produced by bees, known to possess antioxidant and anti-inflammatory activities. A literature search was performed using Pubmed, Scopus, and Web of Science to identify studies on the effects of propolis on bone health. The search string used was (i) propolis AND (ii) (bone OR osteoporosis OR osteoblasts OR osteoclasts OR osteocytes). Eighteen studies were included in the current review. The available experimental studies demonstrated that propolis could prevent bone loss due to periodontitis, dental implantitis, and diabetes in animals. Combined with synthetic and natural grafts, it could also promote fracture healing. Propolis protects bone health by inhibiting osteoclastogenesis and promoting osteoblastogenesis, partly through its antioxidant and anti-inflammatory actions. Despite the promising preclinical results, the skeletal protective effects of propolis are yet to be proven in human studies. This research gap should be bridged before nutraceuticals based on propolis with specific health claims can be developed.

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“…The antibacterial properties of propolis are contributed by its phenol content that causes functional and structural changes in bacteria, such *Corresponding author : Suryono Email : suryonodent@mail.ugm.ac.id as cytoplasm membrane damage, inhibits nucleic acid synthesis, and inhibits the formation of biofilm (Scatolini et al, 2018). Propolis also possesses the ability to regenerate bone by increasing osteoblast activity and decreasing osteoclast activity (Zohery et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Loading and Release Profile Assay of Carbonated Hydroxyapatite Incorporated with Propolis as Bone Graft Material

2020

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Periodontitis can lead to the destruction of the alveolar bone. The loss of the alveolar bone can be treated using carbonated hydroxyapatite (CHA) as a bone graft material. However, CHA is an alloplastic graft whose primary function is to act as a scaffold, but it is unable to stimulate the process of bone regeneration. Carbonated hydroxyapatite is an avascular synthetic material, which will increase the risk of bacterial adhesion on site that can lead to unsuccessful periodontal therapy. The incorporation of propolis into CHA is expected to add antibacterial capability into CHA. Besides its antibacterial property, propolis also has a bone regenerating effect. Mixing CHA with propolis needs to consider the process of loading the active ingredients into the carrier. The release of propolis is expected to occur gradually over a lengthy period. The purpose of this study was to analyze the loading and releasing assay for propolis incorporated with CHA. A propolis solution of 5%, 7.5%, and 10% was each incorporated into 10 mg of CHA. The loading percentage and releasing assay of propolis were measured. The absorbance reading was done at 289 nm using a UV-vis. It was shown that a 10% propolis solution had the highest loading percentage (32.08%), while the 5% propolis solution had the smallest loading percentage (10.63%). The propolis releasing profiles in all concentration groups were similar. The difference in propolis concentration incorporated with CHA affected the loading percentage but did not affect the propolis releasing assay.

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Egyptian propolis compared to nanohydroxyapatite graft in the treatment of Class II furcation defects in dogs

Abstract: Both Egyptian propolis and nanohydroxyapatite graft material showed favorable periodontal regenerative effect. Propolis showed increased cellular proliferative ability that could be beneficial in reducing the healing period needed after periodontal therapy.

Cited by 17 publications

References 44 publications

Management of Class II furcation defects in dogs using combination of Propolis and Nanobone graft

Management of Class II furcation defects in dogs using combination of Propolis and Nanobone graft

Application of Propolis in Protecting Skeletal and Periodontal Health—A Systematic Review

Loading and Release Profile Assay of Carbonated Hydroxyapatite Incorporated with Propolis as Bone Graft Material

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