Role of procalcitonin in the diagnosis of infective endocarditis: a meta-analysis

Yu, Chia-Yi; Juan, Ling-I; Hsu, Shou-Chien; Chen, Chun-Kuei; Wu, Chi-Huan; Lee, Chien‐Chang; Wu, Jialun

doi:10.1016/j.ajem.2013.03.008

Cited by 50 publications

(32 citation statements)

References 23 publications

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“…Jednak żaden z tych parametrów nie jest diagnostyczny dla IZW [61]. Określone badania laboratoryjne wchodzą w skład chirurgicznych systemów punktowych odpowiednich do stratyfikacji ryzyka u pacjentów z IZW, w tym stężenia bilirubiny i kreatyniny oraz liczba płytek krwi (SOFA, Sequential Organ Failure Assesment) oraz klirens kreatyniny (EuroSCORE, European System for Cardiac Operative Risk Evaluation).…”

Section: Badania Laboratoryjneunclassified

2015 ESC Guidelines for the management of infective endocarditis

Habib¹,

Lancellotti

Antunes³

et al. 2015

Kardiol Pol

144

212

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Section: Badania Laboratoryjneunclassified

2015 ESC Guidelines for the management of infective endocarditis

Habib¹,

Lancellotti

Antunes³

et al. 2015

Kardiol Pol

144

212

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“…Some meta-analyses focused on the diagnostic value of procalcitonin for microbiologically confirmed local infection [28][29][30][31][32][33][34][35][36][37][38][39] or bacteraemia [40]. However, the number of included studies was small, specific patient subgroups were analysed or studies concerning sepsis were included as well [28][29][30][31][32][33][34][35][36][37][38][39][40].…”

Section: Introductionmentioning

confidence: 99%

The diagnostic accuracy of procalcitonin for bacteraemia: a systematic review and meta-analysis

Hoeboer

Geest

Nieboer

et al. 2015

Clinical Microbiology and Infection

231

168

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The diagnostic use of procalcitonin for bacterial infections remains a matter of debate. Most studies have used ambiguous outcome measures such as sepsis instead of infection. We performed a systematic review and meta-analysis to investigate the diagnostic accuracy of procalcitonin for bacteraemia, a proven bloodstream infection. We searched all major databases from inception to June 2014 for original, English language, research articles that studied the diagnostic accuracy between procalcitonin and positive blood cultures in adult patients. We calculated the area under the summary receiver-operating characteristic (SROC) curves and pooled sensitivities and specificities. To minimize potential heterogeneity we performed subgroup analyses. In total, 58 of 1567 eligible studies were included in the meta-analysis and provided a total of 16,514 patients, of whom 3420 suffered from bacteraemia. In the overall analysis the area under the SROC curve was 0.79. The optimal and most widely used procalcitonin cut-off value was 0.5 ng/mL with a corresponding sensitivity of 76% and specificity of 69%. In subgroup analyses the lowest area under the SROC curve was found in immunocompromised/neutropenic patients (0.71), the highest area under the SROC curve was found in intensive-care patients (0.88), sensitivities ranging from 66 to 89% and specificities from 55 78%. In spite of study heterogeneity, procalcitonin had a fair diagnostic accuracy for bacteraemia in adult patients suspected of infection or sepsis. In particular low procalcitonin levels can be used to rule out the presence of bacteraemia. Further research is needed on the safety and efficacy of procalcitonin as a single diagnostic tool to avoid taking blood cultures.

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“…В отдельных случаях разви-вается гнойный менингит или эмболические абсцессы мозга. У пожилых пациентов возможно появление сим-птомов токсической энцефалопатии разной степени вы-раженности вплоть до развития галлюцинаций и делирия [4]. Следует иметь в виду, что развитие неврологических осложнений возможно даже в поздние сроки антибакте-риальной терапии.…”

Section: таблицаunclassified

Infective Endocarditis in a Rheumatologist’s Practice: Issues of Its Clinical Presentation and Diagnosis

Белов¹,

Тарасова²

2015

rsp

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Role of procalcitonin in the diagnosis of infective endocarditis: a meta-analysis

Cited by 50 publications

References 23 publications

2015 ESC Guidelines for the management of infective endocarditis

2015 ESC Guidelines for the management of infective endocarditis

The diagnostic accuracy of procalcitonin for bacteraemia: a systematic review and meta-analysis

Infective Endocarditis in a Rheumatologist’s Practice: Issues of Its Clinical Presentation and Diagnosis

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