Abstract:We present a prospective study of patients with tuberculosis of the dorsal, dorsolumbar and lumbar spine after combined anterior (radical debridement and anterior fusion) and posterior (instrumentation and fusion) surgery. The object was to study the progress of interbody union, the extent of correction of the kyphosis and its maintenance with early mobilisation, and the incidence of graft and implant-related problems. The American Spinal Injury Association (ASIA) score was used to assess the neurological stat… Show more
“…Expandable cages have the advantage of a primary stable anchorage and avoidance of the donor site morbidity that occurs with structural autologous bone graft harvesting. Both the present study and studies by other authors have demonstrated that the use of metallic implants in an infected area of the spine does not lead to persistence or recurrence of the infection [4,8,19,21]. In addition to stabilisation of the spine, the good perfusion of the vertebral bodies and adequate soft tissue coverage of the anterior thoracolumbar spine (including immunologically active structures such as the peritoneum) are regarded as the main factors contributing to the success of this technique [4,12].…”
Section: Discussionsupporting
confidence: 60%
“…However, an increasing number of studies advocate a combination of posterior stabilisation and anterior debridement and interbody fusion. The advantages of this technique are better correction of the kyphotic deformity and its maintenance, and earlier patient mobilisation [1,5,7,8,11,14,15,19].…”
Section: Discussionmentioning
confidence: 99%
“…Sundararaj et al [19] reported on 16 patients with tuberculosis of the spine who were surgically treated with anterior debridement and fusion using a titanium mesh cage and posterior stabilisation. The infection was eradicated in all cases.…”
Section: Discussionmentioning
confidence: 99%
“…The reported techniques of surgical treatment range from anterior debridement and interbody fusion [13], debridement and internal fixation from the posterior approach [17] to combined single-stage or twostage posterior instrumentation with anterior debridement and bone grafting [1,5,7,8,11,14,15,19]. Anterior instrumentation or the use of cages has been anecdotally reported, but there is a critical discussion concerning the role of spinal implants in the presence of infection [4,8,19,21].…”
“…Expandable cages have the advantage of a primary stable anchorage and avoidance of the donor site morbidity that occurs with structural autologous bone graft harvesting. Both the present study and studies by other authors have demonstrated that the use of metallic implants in an infected area of the spine does not lead to persistence or recurrence of the infection [4,8,19,21]. In addition to stabilisation of the spine, the good perfusion of the vertebral bodies and adequate soft tissue coverage of the anterior thoracolumbar spine (including immunologically active structures such as the peritoneum) are regarded as the main factors contributing to the success of this technique [4,12].…”
Section: Discussionsupporting
confidence: 60%
“…However, an increasing number of studies advocate a combination of posterior stabilisation and anterior debridement and interbody fusion. The advantages of this technique are better correction of the kyphotic deformity and its maintenance, and earlier patient mobilisation [1,5,7,8,11,14,15,19].…”
Section: Discussionmentioning
confidence: 99%
“…Sundararaj et al [19] reported on 16 patients with tuberculosis of the spine who were surgically treated with anterior debridement and fusion using a titanium mesh cage and posterior stabilisation. The infection was eradicated in all cases.…”
Section: Discussionmentioning
confidence: 99%
“…The reported techniques of surgical treatment range from anterior debridement and interbody fusion [13], debridement and internal fixation from the posterior approach [17] to combined single-stage or twostage posterior instrumentation with anterior debridement and bone grafting [1,5,7,8,11,14,15,19]. Anterior instrumentation or the use of cages has been anecdotally reported, but there is a critical discussion concerning the role of spinal implants in the presence of infection [4,8,19,21].…”
“…Metal implants were considered to hinder healing of the infections with increased rates of septic loosening [15,16]. Indeed, extensive clinical and surgical studies uphold the choice of synthetic material implantation during the acute infective phase of vertebral osteomyelitis [13].…”
Section: Epidemiology and Surgical Indicationsmentioning
Purpose Spondylodiscitis mainly affects the anterior part of the spine. In this paper, we retrospectively analyze our experience with the anterior stand-alone approach (ASAA) in the treatment of spinal infections. Methods Forty consecutive patients with severe spondylodiscitis underwent the ASAA during the acute infective phase. Treatment consisted of disease debridement, vertebral body reconstruction using titanium expandable prostheses and anterior fixation. Results There was neither mortality nor major morbidity. Successful arthrodesis was achieved in 39 out of 40 patients who remained disease free throughout the followup period. Six months after treatment, one patient experienced pseudarthrosis and required supplemented posterior spinal fixation for vertebral instability. However, adequate arthrodesis was eventually obtained even in this patient. Conclusions ASAA with spine reconstruction using synthetic materials during the acute infection phase was safe and effective. The infections were rapidly defeated, the patients were allowed to stand up early after the procedure and the length of hospital stay was significantly reduced.
The two included trials had too few participants to be able to say whether routine surgery might help. Although current medication and operative techniques are now far more advanced, these results indicate that routine surgery cannot be recommended unless within the context of a large, well-conducted randomized controlled trial. Clinicians may judge that surgery may be clinically indicated in some groups of patients. Future studies need to address these topics as well as the patient's view of their disease and treatment.
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