Role of Platelet Rich Plasma in Treatment of Diabetic Foot Ulcers

Salem, Amira; Tawfik, Ahmad M.

doi:10.4236/ss.2016.76038

Cited by 3 publications

(1 citation statement)

References 11 publications

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“…Abdelhafez et al reported an impressive 96% success rate in achieving complete healing with PRP injections for DFUs [ 20 ]. Similarly, Salem and colleagues documented a notable success rate of 97.6% in achieving complete healing with PRP injections for DFUs [ 21 ]. In another study, Murtuza and colleagues reported a commendable 93.33% rate of complete healing in patients treated with PRP for DFUs [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Platelet-Rich Plasma in the Treatment of Diabetic Foot Ulcer

Azam,

Azad,

Arsalan

et al. 2024

Cureus

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IntroductionDiabetic foot complications leading to limb amputations pose a global health concern. Platelet-rich plasma (PRP) gel has emerged as a promising method for ulcer healing, leveraging the growth factors provided by autologous PRP to enhance tissue healing. Therefore, we aimed to assess the frequency of the success of PRP therapy in the treatment of non-healing diabetic foot ulcers. MethodsThis quasi-experimental study, conducted in Lahore, Pakistan, from April 2021 to October 2022, enrolled 80 eligible individuals with non-responsive diabetic foot ulcers using a consecutive sampling technique. Inclusion criteria involved patients of both genders, aged 45-75 years, with unhealed diabetic foot ulcers, and exclusion criteria considered factors such as recurrent ulcers at the same site, smoking, and immunosuppressive or anticoagulant drug therapy. Baseline demographic details, ulcer measurements using a scale, and AutoCAD (Autodesk, Inc., San Francisco, California, United States)-assisted quantification of ulcer base were recorded. Autologous PRP injections were administered following strict aseptic protocols, with dressing changes and assessments performed at specified intervals over four weeks. Treatment success, defined as >90% healing after four weeks, was the primary outcome. Data analysis utilized IBM SPSS Statistics for Windows, Version 26.0 (Released 2019; IBM Corp., Armonk, New York, United States), employing post-stratification chi-square and t-tests where appropriate for significant differences. ResultsThe mean age of the patients was 60.40 ± 9.72 years, the mean duration of diabetes was 9.48 ± 2.21 years, and the mean ulcer duration was 11.41 ± 1.63 months. The treatment success rate was 63.7%. Age, gender, and disease duration showed no significant impact on treatment success. However, patients with a normal BMI and shorter ulcer duration exhibited a significantly higher success rate (p <0.001 and p = 0.002, respectively). ConclusionsThis study reaffirms the efficacy of PRP in treating non-healing diabetic foot ulcers, aligning with previous research. Despite a slightly lower success rate compared to literature reports, PRP remains a promising agent for managing diabetic foot ulcers.

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Section: Discussionmentioning

confidence: 99%

Efficacy of Platelet-Rich Plasma in the Treatment of Diabetic Foot Ulcer

Azam,

Azad,

Arsalan

et al. 2024

Cureus

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Platelet rich plasma and growth factors cocktails for diabetic foot ulcers treatment: State of art developments and future prospects

Gonchar

Липунов

Afanasov³

et al. 2018

Diabetes & Metabolic Syndrome: Clinical Research & Revi

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Efficacy of Intralesional Platelet-Rich Plasma in Diabetic Foot Ulcer

Gupta¹,

Channaveera²,

Sethi³

et al. 2021

Journal of the American Podiatric Medical Association

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Background: Diabetic foot ulcer (DFU) is well managed by infection control, euglycemic state, debridement of ulcer followed by appropriate dressing and off-loading of the foot. Studies have reported that when DFU is properly off-loaded, about 90% of these would heal in nearly six weeks. Platelet rich plasma (PRP) serves as a growth factor agonist and has mitogenic and chemotactic properties which help in DFU healing. To evaluate the efficacy of local application of PRP with respect to healing rate and ulcer area reduction in treating diabetic foot ulcer. Materials and Methods: Sixty non-infected DFU patients with plantar ulcer of size less than 20cm2 and Wagner's Grade 1 & 2 were randomized to receive normal saline dressing (Control group - CG) or PRP dressing (Study group - SG) in conjunction with total contact casting for 6 weeks (or till complete ulcer healing), whichever was earlier. Evaluation was done at weekly interval for healing rate and change in ulcer area.Results: Mean ulcer area of study participants at baseline was 4.96 {plus minus} 2.89cm2 (CG) and 5.22 {plus minus} 3.82cm2 (SG) (p=0.77) which decreased to 1.15{plus minus}1.35cm2 (CG) and 0.96{plus minus}1.53cm2 (SG) (p=0.432) at 6wks. Percent reduction in mean healing area at 6wks was 81.72{plus minus}17.2% and 85.98{plus minus}13.42% in control group and study group respectively (p=0.29). Average rate of healing achieved at 6 weeks was 0.64{plus minus}0.36cm2 and 0.71{plus minus}0.46cm2 in control group and study group respectively (p=0.734). Conclusions: PRP dressing is no more efficacious than normal saline dressing in management of DFU in conjunction with total contact casting.

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Role of Platelet Rich Plasma in Treatment of Diabetic Foot Ulcers

Cited by 3 publications

References 11 publications

Efficacy of Platelet-Rich Plasma in the Treatment of Diabetic Foot Ulcer

Efficacy of Platelet-Rich Plasma in the Treatment of Diabetic Foot Ulcer

Platelet rich plasma and growth factors cocktails for diabetic foot ulcers treatment: State of art developments and future prospects

Efficacy of Intralesional Platelet-Rich Plasma in Diabetic Foot Ulcer

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