Platelet rich plasma and growth factors cocktails for diabetic foot ulcers treatment: State of art developments and future prospects

Gonchar, Ivan V.; Липунов, А. Р.; Afanasov, I. M.; Ларина, В. Н.; Faller, A.P.; Kibardin, Alexey

doi:10.1016/j.dsx.2017.09.007

Cited by 27 publications

(10 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The PRP is obtained by centrifugation, separation, and concentration of the peripheral venous blood of patients. Many studies have shown that APG promotes the healing of chronic wounds by enhancing the concentration of various growth factors (GFs), maintaining the balance of the matrix metalloproteinase (MMP) system, and providing fibrin mesh scaffolds . Autologous platelet‐rich gel is an inexpensive and immunologically safe source of growth factors.…”

Section: Introductionmentioning

confidence: 99%

Autologous platelet‐rich gel treatment for diabetic chronic cutaneous ulcers: A meta‐analysis of randomized controlled trials

Gao

et al. 2018

Journal of Diabetes

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

Autologous platelet‐rich gel treatment for diabetic chronic cutaneous ulcers: A meta‐analysis of randomized controlled trials

Gao

et al. 2018

Journal of Diabetes

View full text Add to dashboard Cite

show abstract

“…Specifically, PRP contains platelet-derived growth factors (PDGF) and transforming growth factor (TGF)-β, which are able to stimulate the proliferation of mesenchymal cells; it also contains vascular endothelial growth factors (VEGFs) and fibroblast growth factor (FGF), which are able to stimulate new blood vessel formation [ 5 ]. This is the reason why the usage of platelet-rich plasma has been introduced as an adjunctive therapy in different medical fields [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Platelet-Rich Plasma (PRP) Rinses for the Treatment of Non-Responding Oral Lichen Planus: A Case Report

et al. 2018

View full text Add to dashboard Cite

Platelet-rich plasma (PRP) has been proposed for different applications in the medical field and in maxillofacial surgery thanks to its many growth factors, such as epidermal growth factor (EGF), fibroblast growth factor (FGF), and keratinocyte growth factor (KGF). Oral lichen planus (OLP) is a disease that affects the oral mucosa in a chronic way. This disease frequently worsens the quality of life of patients, particularly when clinical manifestations are of the erythematous or erosive/ulcerative type. The properties of PRP that are supported by scientific literature in both oral medicine and other medical fields have suggested the introduction of PRP in clinical practice for the medical treatment of different soft tissues diseases, such as when OLP patients do not respond to conventional therapies, or when conventional treatments have some contraindications or side effects. The aim of this work is to describe the use of PRP used as an oral rinse for the treatment of a patient diagnosed as affected by OLP at the Dentistry, Special Needs and Maxillo-Facial Surgery Unit of the Hospital of Piacenza. PRP protocol was started after the failure of conventional therapies based on the use of topical and systemic corticosteroids, hydroxychloroquine, and low-level laser therapy applications.

show abstract

“…Several growth factors are released, which facilitate the therapeutic function of PRP. These growth factors include: Keratinocyte growth factor (KGF), platelet-derived growth factor AB (PDGF-AB), vascular endothelial growth factor (VEGF), insulin-like growth factor 1 and 2 (ILGF), transforming growth factor β1 (TGF β1), epithelial growth factor (EGF), fibroblast growth factor (FGF), and connective tissue growth factor (CTGF) (7) . Interleukin 8 (IL-8) chemokine facilitates circulation, blood flow and angiogenesis, which is one of PRP components beside the other previous mentioned growth factors (8) .…”

Section: Intralesional Platelet-rich Plasmamentioning

confidence: 99%

Intralesional Platelet-Rich Plasma in the Treatment of Oral Lichen Planus: Review Article

El-sayed¹,

Ghoneimy²,

ElGhareeb³

et al. 2021

The Egyptian Journal of Hospital Medicine

View full text Add to dashboard Cite

Background: a lingering disease of inflammatory type called oral lichen planus (OLP) affects the oral mucosa. It can be presented at one of the following forms: ulcerative, erosive, hyperkeratotic and reticular form. Patients usually feel discomfort, burning sensation, pain and changes of the life quality. Mostly it affects women of middle ages and to a lesser extent affects children. There are many therapeutic modalities in treatment of OLP but mostly no effective results are obtained and patient satisfaction is poor and recurrence occurred. Intralesional platelet-rich plasma is used to treat erosive dermatological lesion, it depends on its high concentration of growth factors that prompt healing. Objective: To study the effect of intralesional platelet-rich plasma in the treatment of oral lichen planus. Conclusion: Intralesional platelet-rich plasma is a good and safe modality for treatment of oral lichen planus.

show abstract

Platelet rich plasma and growth factors cocktails for diabetic foot ulcers treatment: State of art developments and future prospects

Cited by 27 publications

References 49 publications

Autologous platelet‐rich gel treatment for diabetic chronic cutaneous ulcers: A meta‐analysis of randomized controlled trials

Autologous platelet‐rich gel treatment for diabetic chronic cutaneous ulcers: A meta‐analysis of randomized controlled trials

Platelet-Rich Plasma (PRP) Rinses for the Treatment of Non-Responding Oral Lichen Planus: A Case Report

Intralesional Platelet-Rich Plasma in the Treatment of Oral Lichen Planus: Review Article

Contact Info

Product

Resources

About