Role of Platelet count as important prognostic marker in Pregnancy Induced Hypertension

Sameer, Dr.M.A.; Meshram, Dr.D.P.; Deshpande, Dr.S.A.; Sadhu, Dr.D.; S, Dr.Pandit

doi:10.9790/0853-13433943

Cited by 12 publications

(8 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…18 Similarly Sameer et al observed patients of mild pre eclampsia and severe pre-eclampsia were all more frequent in primiparous women accounting for 66.03% and 65.51% cases respectively. 19 In present study severe pre-eclampsia 67.5% patients were primigravidae, followed by 22.5% cases of second gravidae and 10% of third or more gravidae. The present findings correlate with authors in respect of severe preeclampsia.…”

Section: Discussionsupporting

confidence: 48%

A comparison of platelet count in severe preeclampsia, mild preeclampsia and normal pregnancy

Gupta¹,

Gaur²,

Mishra³

et al. 2018

Int J Res Med Sci

View full text Add to dashboard Cite

Background: Preeclampsia, the most common of hypertensive disorders of pregnancy is an idiopathic multisystem disorder affecting 2 – 10% of all pregnancies and together they form one member of the deadly triad, along with hemorrhage and infection that contribute greatly to the maternal morbidity and mortality rates. The identification of this clinical entity and effective management play a significant role in the outcome of pregnancy. Platelet count is emphasized to play a significant role in hemostasis mechanism of preeclampsia and the degree of thrombocytopenia increases with severity of preeclampsia. This study was conducted to find correlation of platelet count in severe preeclampsia, mild preeclampsia and normal subjects.Methods: Total 140 subjects, 70 control and 70 cases were enrolled in the study. Samples for platelet count were collected and estimation was carried out by the auto-analyzers. The statistical evaluation is done using SPSS version 22 along with Anova and student t-test.Results: The mean platelet count was significantly lower (p <0.05) in mild and severe preeclampsia than that in the normal pregnancy. Decreased platelet count in severe preeclampsia was significant compared to that in mild preeclampsia.Conclusions: The frequency of thrombocytopenia was found to be directly related with the severity of disease, so platelet count can be used as a simple and cost effective tool to monitor the progression of preeclampsia, thereby preventing complications to develop during the gestational period.

show abstract

Section: Discussionsupporting

confidence: 48%

A comparison of platelet count in severe preeclampsia, mild preeclampsia and normal pregnancy

Gupta¹,

Gaur²,

Mishra³

et al. 2018

Int J Res Med Sci

View full text Add to dashboard Cite

show abstract

“…Similarly, another study [ 29 ] reported a similar finding of 30 cases of thrombocytopenia; among these, 9 cases were in non-severe pre-eclampsia and 21 in severe pre-eclampsia. On the contrary, other studies [ 39 , 40 ] showed a slightly higher number of cases, 33 cases (56%) within the severe pre-eclampsia group. Other studies [ 41 , 42 ] found 11 and 16 cases of severe pre-eclampsia, respectively.…”

Section: Discussionmentioning

confidence: 65%

A pattern of platelet indices as a potential marker for prediction of pre-eclampsia among pregnant women attending a Tertiary Hospital, Ethiopia: A case-control study

Bawore¹,

Adissu

Niguse³

et al. 2021

PLoS ONE

View full text Add to dashboard Cite

Introduction Preeclampsia is the most serious health risk during pregnancy for both the mother and the fetus. Even though platelet parameters are among the proposed biomarkers for the prediction of preeclampsia, the use of its indices in the diagnosis of preeclampsia is not increasing in Ethiopia. There is little information on platelet patterns in preeclampsia and normal pregnancy. The purpose of this study was to determine the pattern of platelet indices in women with preeclampsia in our study setting. Methods A case-control study was conducted among 180 pregnant women who attended anti-natal follow-ups from January 1 to April 3, 2019. An Ethylene Diamine Tetra Acetic Acid anti-coagulated venous blood was collected and analyzed using a hematology analyzer (MINDRAY®-BC-300Plus, Shenzhen China). The SPSS software version 26 was used to run the Mann Whitney U test, Kruskal-Wallis H test, and Kolmogorov-Smirnov normality test, Post-hock test augmented with Benforeni, receiver operating characteristics curve, and Spear Man rank-order correlation. A P-value of <0.05 was considered statistically significant. Results A total of 180 pregnant women were included in the study. Platelet count and platelet crit levels tend to decrease as pre-eclampsia becomes more severe. In contrast, the mean platelet volume and platelet distribution widths were significantly increased with the severity of preeclampsia (P<0.001). Platelet distribution width (rho = 0.731, p<0.001) and mean platelet volume (rho = 0.674, p<0.001) had statistically significant positive relationships with mean arterial pressure. The best metric for predicting preeclampsia was platelet distribution width (AUC = 0.986; 95%CI; 0.970, 1). Conclusions Platelet indices, including platelet count, mean platelet volume, platelet distribution width, and Platelet crit, have been identified as promising candidate markers for predicting preeclampsia in pregnant women. In the future, a serial examination of these indicators during several trimesters of pregnancy should be conducted.

show abstract

“…Thrombocytopenia in pregnancy-induced hypertensive women may be due to increased adherence of platelets at the site of damaged vascular endothelium leading to increased consumption and secondary destruction of platelets. There is activation of platelets along with increased degranulation leading to decrease in platelet life span and increase in number of immature platelets in peripheral blood smears [1,4].…”

Section: Introductionmentioning

confidence: 99%

Role of Platelet Distribution Width (PDW) and Plateletcrit in the Assessment of Nonthrombocytopenic Preeclampsia and Eclampsia

Singh

Varma

2017

J Obstet Gynecol India

View full text Add to dashboard Cite

show abstract

Role of Platelet count as important prognostic marker in Pregnancy Induced Hypertension

Abstract: : Introduction: Pregnancy induced hypertension (PIH) includes gestational hypertension

Cited by 12 publications

References 10 publications

A comparison of platelet count in severe preeclampsia, mild preeclampsia and normal pregnancy

A comparison of platelet count in severe preeclampsia, mild preeclampsia and normal pregnancy

A pattern of platelet indices as a potential marker for prediction of pre-eclampsia among pregnant women attending a Tertiary Hospital, Ethiopia: A case-control study

Role of Platelet Distribution Width (PDW) and Plateletcrit in the Assessment of Nonthrombocytopenic Preeclampsia and Eclampsia

Contact Info

Product

Resources

About