Role of Plasma Von Willebrand Factor-Antigen in predicting the presence of Esophageal Varices and occurrence of its bleeding in cirrhotic patients

Abdelmaksoud, Mona Ahmed; Jouda, Amal A; Fathy, Talaat; Ibrahim, Ahmad Mokhtar Ahmad; Soliman, Ahmed; Baraka, Ahmad; Elkhashab, Mohammad N

doi:10.21608/aeji.2019.12190.1020

Cited by 3 publications

(3 citation statements)

References 12 publications

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“…This also agrees with Eltoukhy and Issa [20], who found that the presence of varices is not affected by the type of viral hepatitis or the history of bilharziasis. This also agrees with AbdelMaksoud et al [21], who found that there were no significant differences as regards age, gender, viral hepatitis, or bilharziasis between cirrhotic patients with and without varices. There were no statistically significant differences between both groups, regarding lower limb edema, ascites, or encephalopathy; these findings agree with that reported by Madhotra et al [12], except that ascites in the latter study were more frequent and severe in patients with EV.…”

Section: Discussionsupporting

confidence: 92%

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Evaluation of serum kallistatin level as a predictor of esophageal varices in cirrhotic patients

Sobhey

Jouda

Metwally

et al. 2020

Alexandria Journal of Medicine

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Introduction: The Baveno VI consensus recommended the use of noninvasive predictors to identify patients at high risk of esophageal varices (EV) in whom endoscopic evaluation is most needed. Kallistatin is a protein molecule synthesized by the liver, and its level declines with the deterioration of liver functions. We aim to explore the role of kallistatin as a predictor of esophageal varices. Methods: This case-control study included 70 cirrhotic patients (35 patients with EV and 35 patients without EV). The laboratory investigations and upper GI endoscopy were performed, and the serum kallistatin level was measured in all patients.Results: The mean level of serum kallistatin was significantly lower in patients with varices (12.2 ± 5.6 vs 16.9 ± 4.8 µg/ml, p = 0.009). It also shows a significant decline in patients with large varices. Kallistatin can predict the presence of EV and large EV at cut off values of 15.8 and 8.9 µg/ml, respectively, with sensitivity and specificity of 71.4% and 54.3% for EV and 50% and 94.8% for large EV. Discussion: Kallistatin is a promising marker that can be used to predict the presence of esophageal varices especially when they are large and risky.

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Section: Discussionsupporting

confidence: 92%

“…This may be because most of the patients with EV in the latter study were Child B grade. These findings also agree with AbdelMaksoud et al [21], who found that there was not any clinical sign of liver disease that can be specifically linked to the presence of esophageal varices.…”

Section: Discussionsupporting

confidence: 92%

Evaluation of serum kallistatin level as a predictor of esophageal varices in cirrhotic patients

Sobhey

Jouda

Metwally

et al. 2020

Alexandria Journal of Medicine

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“…Regarding varices, a recent Egyptian study conducted by Abdelmaksoud et al (24) demonstrated that, VWF rise significantly in patients with esophageal varices (169.3±20.2 in cases vs 146.8±35.5 µg/dL in the controls p<0.001). Thus, the demonstrated that, such marker can be reliable in prediction of the presence of EV.…”

Section: Discussionmentioning

confidence: 92%

Von Willebrand Factor; a New Non-Invasive Marker for Assessment of Liver Fibrosis in Infants and Children

Abdelrazek¹,

Mansour²,

Barakat³

et al. 2022

The Egyptian Journal of Hospital Medicine

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Background: Von Willebrand Factor (vWF) is a multimeric adhesive protein to which platelets stick. It is physiologically released by activated endothelial cells during primary hemostasis. High Shear stress induced by hyperdynamic (splanchnic) circulation in advanced hepatic fibrosis as well as endotoxinemia caused by bacterial translocation may contribute to the increased levels of vWF releasing from that activated endothelium. Objective: The aim of the current work was to assess the stage of fibrosis changes in children with CLD noninvasively by measuring the levels of serum Vwf Ag. Patients and Methods: This was an observational case control study conducted on sample of 40 infants and children up to 18 years divided into two equal groups of 20 cases (fibrotic) attending hepatic clinic at Mansoura University Children' Hospital and another 20 healthy matched controls. The diagnosis of fibrosis was previously verified by clinical, biochemical, ultrasonographic criteria and biopsy. Results: There was highly statistically significant increase in vWF value in the cases compared to the controls (167.1  47.8 Vs 112.9  36.1 IU/dL) (P<0.001). vWF Ag values demonstrated insignificant differences concerning etiology of liver disease, presence or absence of ascites and hepatosplenomegaly (P>0.05). Values of vWF Ag were demonstrated to be significantly increases in cases with severe fibrosis as well as cases with varices (P<0.05). There were highly statistically significant correlations between vWF Ag level and both fibrosis stage and Child Score among the studied patients (P≤0.001). Conclusion:It could be concluded Willebrand factor antigen level was positively correlated with liver function tests as well as varices and could be used as a significant predictor to severity of liver fibrosis and / or cirrhosis in children and infants with chronic liver disease.

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Role of plasma von Willebrand factor antigen in prediction of esophageal varices in pediatric and adolescent patients with portal hypertension

Shazli

Abdelhady

Abdelaziz

2021

Egypt Liver Journal

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Background Ruptured esophageal varices (EVs) are a leading cause of death in Portal hypertension (PHT), it has been a big concern of research to screen EVs through non-invasive approaches. This study aimed to evaluate the role of plasma von Willebrand factor antigen (VWF-Ag) assay for early detection of EVs in patients with portal hypertension. This was a cross-sectional study, done on 47 portal hypertensive children and adolescents who were collected from the Pediatrics Hepatology Clinic, Children Hospital, Ain Shams University. All patients were subjected to comprehensive history taking, thorough clinical examination, routine investigations, abdominal ultrasound, upper GI endoscopy, and measurement of plasma VWF-Ag level. The patients were divided based on their endoscopic findings into two groups; a varices group which included 37 patients, and a non-varices group which included 10 patients. Results VWF-Ag rise significantly in patients with EVs, revealing a direct positive association with the degree of EVs. Conclusion The plasma VWF-Ag can be applied as a non-invasive evidence of the presence and grading of EVs.

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Role of Plasma Von Willebrand Factor-Antigen in predicting the presence of Esophageal Varices and occurrence of its bleeding in cirrhotic patients

Cited by 3 publications

References 12 publications

Evaluation of serum kallistatin level as a predictor of esophageal varices in cirrhotic patients

Evaluation of serum kallistatin level as a predictor of esophageal varices in cirrhotic patients

Von Willebrand Factor; a New Non-Invasive Marker for Assessment of Liver Fibrosis in Infants and Children

Role of plasma von Willebrand factor antigen in prediction of esophageal varices in pediatric and adolescent patients with portal hypertension

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